公开(公告)号：US20110166028A1

公开(公告)日：2011-07-07

申请号：US12674981

申请日：2008-08-22

Applicant: Donald Bergstrom ,  Xudong Dai ,  James Hardwick ,  Cole Liberator ,  A. Thomas Look ,  Jennifer O'Neil ,  Sudhir Rao ,  Peter Strack ,  Christopher Winter ,  Theresa Zhang

Inventor： Donald Bergstrom ,  Xudong Dai ,  James Hardwick ,  Cole Liberator ,  A. Thomas Look ,  Jennifer O'Neil ,  Sudhir Rao ,  Peter Strack ,  Christopher Winter ,  Theresa Zhang

IPC: C40B30/00 ,  C12Q1/68 ,  G01N33/53

CPC classification number: C12Q1/6886 ,  C12Q2600/106

Abstract: The invention relates to the identification and use of gene expression profiles with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. The same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. The methods may further comprise selecting a treatment based on the classifying step.

Abstract translation: 本发明涉及鉴定和使用与细胞增殖性疾病的治疗有关的基因表达谱，特别是使用Notch信号传导抑制剂由异常Notch信号转导介导的基因表达谱。 特别地，本发明提供基因的身份，其个体或累积表达模式可用于各种测定。 基因表达谱，无论是体现在核酸表达，蛋白质表达或其他表达形式中，都可用于选择患有Notch介导的癌症的受试者，其可能对用γ-分泌酶抑制剂或另一种Notch抑制剂治疗有反应。 在用其他Notch抑制剂治疗的患者的分类中可以使用相同的标记。 该方法还可以包括基于分类步骤提供诊断，预测或预测信息。 所述方法可以进一步包括基于分类步骤来选择治疗。

公开(公告)号：US07814481B1

公开(公告)日：2010-10-12

申请号：US10646453

申请日：2003-08-21

Applicant: John Thomas Welder ,  Ratheesh Krishna Vadhyar ,  Sudhir Rao ,  Thomas W. Uban

Inventor： John Thomas Welder ,  Ratheesh Krishna Vadhyar ,  Sudhir Rao ,  Thomas W. Uban

IPC: G06F9/445 ,  G06F15/177

CPC classification number: G06F8/65 ,  G06F15/177 ,  H04L41/00

Abstract: A method and system for resetting a network device. Specifically, in one embodiment, a method is disclosed for upgrading and/or reloading software for a network device with minimal disruption. The method begins by separating operations associated with layer two of an International Standardization Organization Open Systems Interconnect (ISO/OSI) reference model from other layers in the ISO/OSI reference model in a network device. Then, the software operations in layer two of the network device are reset. The software operations are reset while maintaining continuity for a communication session between the network device and other network devices coupled together through a network. Thereafter, for minimal disruption, execution of the software operations is recovered at layer two before continuity of the communication session s terminated.

Abstract translation: 一种用于重置网络设备的方法和系统。 具体地，在一个实施例中，公开了一种用于以最小的中断来升级和/或重新加载用于网络设备的软件的方法。 该方法从网络设备中的ISO / OSI参考模型中的其他层与国际标准化组织开放系统互连（ISO / OSI）参考模型的第二层相关联的操作开始。 然后，复位网络设备二层的软件操作。 复位软件操作，同时保持网络设备和通过网络耦合在一起的其他网络设备之间的通信会话的连续性。 此后，为了最小的中断，在通信会话的连续性终止之前，第二层恢复软件操作的执行。

公开(公告)号：US20070073828A1

公开(公告)日：2007-03-29

申请号：US11223174

申请日：2005-09-08

Applicant: Sudhir Rao ,  Roger Raphael

Inventor： Sudhir Rao ,  Roger Raphael

IPC: G06F15/16

CPC classification number: H04L67/1097 ,  H04L69/324 ,  H04L69/40

Abstract: An apparatus, system, and method are disclosed for link layer message transfer. The apparatus to facilitate link layer message transfer includes a queue module, a calculation module, and a transmit module. The queue module recognizes a transmission queue element associated with an outgoing transmission queue. The transmission queue element is directed from a source host to a target host. The calculation module calculates a target host address of a message array on a shared storage device. The shared storage device is coupled to the source and target hosts. The transmit module transmits a message from the source host to the target host address of the message array on the shared storage device.

Abstract translation: 公开了用于链路层消息传送的装置，系统和方法。 用于促进链路层消息传送的装置包括队列模块，计算模块和发射模块。 队列模块识别与输出传输队列相关联的传输队列元素。 传输队列元素从源主机引导到目标主机。 计算模块计算共享存储设备上消息数组的目标主机地址。 共享存储设备耦合到源和目标主机。 发送模块将消息从源主机发送到共享存储设备上的消息数组的目标主机地址。

公开(公告)号：US20070016822A1

公开(公告)日：2007-01-18

申请号：US11182469

申请日：2005-07-15

Applicant: Sudhir Rao ,  Bruce Jackson ,  Soumitra Sarkar

Inventor： Sudhir Rao ,  Bruce Jackson ,  Soumitra Sarkar

IPC: G06F11/00

CPC classification number: G06F9/5061 ,  G06F11/1425 ,  G06F2209/505 ,  H04L67/1002 ,  H04L67/1008 ,  H04L67/322

Abstract: A system, method and computer program product for use in a server cluster having plural server nodes implementing a server tier in a client-server computing architecture in order to determine which of two or more partitioned server subgroups has a quorum. A determination is made of relative priorities of the subgroups and a quorum is awarded to the subgroup having a highest relative priority. The relative priorities are determined by policy rules that evaluate comparative server node application state information. The server node application state information may include one or more of client connectivity, application priority, resource connectivity, processing capability, memory availability, and input/output resource availability, etc. The policy rules evaluate the application state information for each subgroup and can assign different weights to different types of application state information. An interface may be provided for receiving policy rules specified by a cluster application.

Abstract translation: 一种在服务器集群中使用的系统，方法和计算机程序产品，其具有在客户端 - 服务器计算架构中实现服务器层的多个服务器节点，以便确定两个或更多个分区服务器子组中的哪一个具有仲裁。 确定子组的相对优先级，并且向具有最高相对优先级的子组授予法定人数。 相对优先级由评估比较服务器节点应用状态信息的策略规则确定。 服务器节点应用状态信息可以包括客户端连接，应用优先级，资源连接性，处理能力，存储器可用性和输入/输出资源可用性等中的一个或多个。策略规则评估每个子组的应用状态信息并且可以分配 不同权重的不同类型的应用状态信息。 可以提供用于接收由集群应用指定的策略规则的接口。

公开(公告)号：US08135424B2

公开(公告)日：2012-03-13

申请号：US12327543

申请日：2008-12-03

Applicant: Yadunandana N. Rao ,  Apoorv Chaudhri ,  Sudhir Rao

Inventor： Yadunandana N. Rao ,  Apoorv Chaudhri ,  Sudhir Rao

IPC: H04B7/00 ,  H04B15/00

CPC classification number: H04B7/0452 ,  H04W72/02

Abstract: A cooperative sensing technique (300) operates by selecting a group of subscribers (302) from a secondary system, measuring a cooperative sensing metric (306) and then using the metric to identify an achievable spatial diversity gain for the group of selected subscribers (308). Once an achievable spatial diversity gain is determined for the group (308/412), it is compared to a required spatial diversity gain (310), and if the condition is met at (310), the validated group can begin spectrum sensing (314) to identify a vacant/suitable channel for operation. If the achievable spatial diversity gain is insufficient, then a new group of users is selected (312) within the secondary system and the process repeats itself.

Abstract translation: 协作感测技术（300）通过从次系统选择一组订户（302）来操作，测量协作感测度量（306），然后使用度量来识别所选择的用户组（308）的可实现的空间分集增益 ）。 一旦为组确定可实现的空间分集增益（308/412），则将其与所需的空间分集增益（310）进行比较，如果在（310）满足条件，则验证组可以开始频谱感测（314 ）来确定一个空的/合适的操作通道。 如果可实现的空间分集增益不足，则在辅助系统内选择一组新的用户（312），并且该过程重复。

公开(公告)号：US20060294413A1

公开(公告)日：2006-12-28

申请号：US11168858

申请日：2005-06-28

Applicant: Frank Filz ,  Bruce Jackson ,  Sudhir Rao

Inventor： Frank Filz ,  Bruce Jackson ,  Sudhir Rao

IPC: G06F11/00

CPC classification number: G06F11/1433 ,  G06F8/65 ,  H04L67/1097 ,  H04L67/34 ,  H04L69/40

Abstract: A method and system are provided for conducting a cluster software version upgrade in a fault tolerant and highly available manner. There are two phases to the upgrade. The first phase is an upgrade of the software binaries of each individual member of the cluster, while remaining cluster members remain online. Completion of the first phase is a pre-requisite to entry into the second phase. Upon completion of the first phase, a coordinated cluster transition is performed during which the cluster coordination component performs any required upgrade to its own protocols and data structures and drives all other software components through the component specific upgrade. After all software components complete their upgrades and any required data conversion, the cluster software upgrade is complete. A shared version control record is provided to manage transition of the cluster members through the cluster software component upgrade.

Abstract translation: 提供了以容错和高可用性方式进行集群软件版本升级的方法和系统。 升级有两个阶段。 第一阶段是升级群集中每个成员的软件二进制文件，而剩余的群集成员保持在线状态。 完成第一阶段是进入第二阶段的先决条件。 在第一阶段完成后，执行协调的集群转换，在此期间，集群协调组件执行任何所需的升级到其自身的协议和数据结构，并通过组件特定升级驱动所有其他软件组件。 所有软件组件完成升级和任何所需的数据转换后，集群软件升级完成。 提供共享版本控制记录，以管理集群成员通过集群软件组件升级的转换。

公开(公告)号：US20100137014A1

公开(公告)日：2010-06-03

申请号：US12327543

申请日：2008-12-03

Applicant: Yadunandana N. Rao ,  Apoorv Chaudhri ,  Sudhir Rao

Inventor： Yadunandana N. Rao ,  Apoorv Chaudhri ,  Sudhir Rao

IPC: H04B7/00

CPC classification number: H04B7/0452 ,  H04W72/02

Abstract: A cooperative sensing technique (300) operates by selecting a group of subscribers (302) from a secondary system, measuring a cooperative sensing metric (306) and then using the metric to identify an achievable spatial diversity gain for the group of selected subscribers (308). Once an achievable spatial diversity gain is determined for the group (308/412), it is compared to a required spatial diversity gain (310), and if the condition is met at (310), the validated group can begin spectrum sensing (314) to identify a vacant/suitable channel for operation. If the achievable spatial diversity gain is insufficient, then a new group of users is selected (312) within the secondary system and the process repeats itself.

Abstract translation: 协作感测技术（300）通过从次系统选择一组订户（302）来操作，测量协作感测度量（306），然后使用度量来识别所选择的用户组（308）的可实现的空间分集增益 ）。 一旦为组确定可实现的空间分集增益（308/412），则将其与所需的空间分集增益（310）进行比较，如果在（310）满足条件，则验证组可以开始频谱感测（314 ）来确定一个空的/合适的操作通道。 如果可实现的空间分集增益不足，则在辅助系统内选择一组新的用户（312），并且该过程重复。

公开(公告)号：US20080239944A1

公开(公告)日：2008-10-02

申请号：US11731586

申请日：2007-03-29

Applicant: Ramprasad Golla ,  Sudhir Rao

Inventor： Ramprasad Golla ,  Sudhir Rao

IPC: G01R31/08

CPC classification number: H04L43/16 ,  H04L41/0681 ,  H04L43/0811 ,  H04L65/1016

Abstract: In an embodiment, a system and method which monitors a signaling plane for error events among one or more network nodes in a converged network. The system and method classifies and calculates, based on user defined parameters, a threshold value or percentage of error events which occur within a desired amount of time and automatically triggers an alert in the network that a potential network connectivity problem exists in the transport plane. In an embodiment, the trigger automatically initiates troubleshooting procedures to solve the network connectivity problem.

Abstract translation: 在一个实施例中，一种在融合网络中的一个或多个网络节点之中监视信令平面以用于错误事件的系统和方法。 系统和方法基于用户定义的参数来分类和计算在期望的时间量内发生的错误事件的阈值或百分比，并且自动地触发网络中的警报在传输平面中存在潜在的网络连接问题。 在一个实施例中，触发器自动启动故障排除过程以解决网络连接问题。

公开(公告)号：US20060106890A1

公开(公告)日：2006-05-18

申请号：US10989664

申请日：2004-11-16

Applicant: Vipul Paul ,  Scott Piper ,  Sudhir Rao

Inventor： Vipul Paul ,  Scott Piper ,  Sudhir Rao

IPC: G06F12/00 ,  G06F17/30

CPC classification number: G06F12/0815

Abstract: An apparatus, system, and method are disclosed for cache synchronization within a multi-tier system having multiple client-server relationships. The apparatus includes a pre-synchronization module, a locking module, and a synchronization module. The pre-synchronization module receives a pre-synchronization call from an upstream node coupled to a first downstream node. The locking module locks a first cache coupled to the first downstream node in response to a synchronization call from the upstream node. The synchronization module synchronizes source data on the upstream node with cached data on the first cache. The apparatus also may include a post-synchronization module to perform any necessary cleanup activities. Advantageously, the apparatus, system, and method reduce the likelihood of a system deadlock due to premature locking of the first downstream cache, which prevents a subsequent downstream cache from synchronizing with the first cache.

Abstract translation: 公开了一种用于具有多个客户机 - 服务器关系的多层系统中的高速缓存同步的装置，系统和方法。 该装置包括预同步模块，锁定模块和同步模块。 预同步模块从耦合到第一下游节点的上游节点接收预同步呼叫。 响应于来自上游节点的同步调用，锁定模块锁定耦合到第一下游节点的第一高速缓存。 同步模块将上游节点上的源数据与第一个缓存上的缓存数据进行同步。 该装置还可以包括执行任何必要的清除活动的后同步模块。 有利地，装置，系统和方法减少了由于第一下游高速缓存的过早锁定而导致的系统死锁的可能性，这阻止随后的下游高速缓存与第一高速缓存同步。

公开(公告)号：US20050283658A1

公开(公告)日：2005-12-22

申请号：US10850749

申请日：2004-05-21

Applicant: Thomas Clark ,  Austin D'Costa ,  Sudhir Rao ,  James Seeger

Inventor： Thomas Clark ,  Austin D'Costa ,  Sudhir Rao ,  James Seeger

IPC: G06F11/00

CPC classification number: G06F11/2048 ,  G06F11/1482 ,  G06F11/2025 ,  G06F11/2028 ,  G06F11/203 ,  G06F11/2046

Abstract: A method, apparatus and program storage device for providing failover for continuous or near-continuous availability in an N-way logical shared-nothing cluster system is disclosed. Cluster application data space partitions are assigned to each node in the cluster and each node's or server software's internal architecture is partitioned in accordance with the application data partitions assigned to the node. Cluster-integrity protection is performed. A failover and recovery protocol is performed based upon the assigned partitions and the partitioned and bound internal architecture. Containment of the impact of failure is provided such that most of the application data space partitions are not impacted. Affected partition sets are failed over fast and in constant time and so actual load on the surviving nodes does not affect failover duration. When shared storage is not provided, synchronous log replication may be used to facilitate failover and log-based recovery.

Abstract translation: 公开了一种用于在N路逻辑无共享集群系统中提供连续或近连续可用性的故障转移的方法，装置和程序存储设备。 集群应用数据空间分区分配给集群中的每个节点，并且每个节点或服务器软件的内部架构根据分配给节点的应用程序数据分区进行分区。 执行集群完整性保护。 基于分配的分区和分区和绑定的内部架构来执行故障转移和恢复协议。 提供了对故障影响的控制，使得大多数应用数据空间分区不受影响。 受影响的分区集在快速和恒定的时间内故障，因此幸存节点上的实际负载不会影响故障转移持续时间。 当不提供共享存储时，可以使用同步日志复制来促进故障转移和基于日志的恢复。