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    N-Amino alkyl indole compounds compositions containing same, and a method of using same in therapy of disorders of gastrointestinal motility
    3.
    发明授权
    N-Amino alkyl indole compounds compositions containing same, and a method of using same in therapy of disorders of gastrointestinal motility 失效
    包含其的N-氨基烷基吲哚化合物组合物及其在胃肠蠕动障碍治疗中的应用方法

    公开(公告)号：US4374846A

    公开(公告)日：1983-02-22

    申请号：US172023

    申请日：1980-07-24

    申请人： Henning Heinemann ,  Heinrich-Wilhelm Ohlendorf ,  Klaus-Ulrich Wolf

    发明人： Henning Heinemann ,  Heinrich-Wilhelm Ohlendorf ,  Klaus-Ulrich Wolf

    IPC分类号： C07D209/38 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/55 ,  A61P1/00 ,  C07D209/14 ,  C07D209/32 ,  C07D209/42 ,  A61K31/435 ,  C07D401/06

    CPC分类号： C07D209/42

    摘要： Novel N-amino alkyl indole compounds are disclosed. These compounds correspond to the Formula I ##STR1## In said Formula R.sub.1 indicates the hydrogen atom, an alkyl group with 1 to 4 carbon atoms, which may be substituted by a phenyl group, or the acetyl group;R.sub.2 indicates the hydroxy carbonyl group, an alkoxy carbonyl group with 1 to 4 alkyl carbon atoms, the cyano group, the amino carbonyl group, a mono-alkyl amino carbonyl group with 1 to 4 alkyl carbon atoms, or a di-alkyl amino carbonyl group with 1 to 4 alkyl carbon atoms, with the proviso that, when R.sub.2 is the hydroxy carbonyl group, then R.sub.1 is other than the hydrogen atom;A indicates an alkylene group with 2 to 5 carbon atoms;R.sub.3 and R.sub.4 are the same or different substituents and indicate the hydrogen atom, an alkyl group with 1 to 4 carbon atoms, or R.sub.3 and R.sub.4 are an alkylene group forming, together with the nitrogen atom to which they are attached, a heterocyclic ring with 5 to 7 ring members; andR.sub.5 and R.sub.6 are the same or different substituents and indicate hydrogen and halogen atoms, alkyl groups with 1 to 3 carbon atoms, alkoxy groups with 1 to 3 carbon atoms, or one of said substituents R.sub.5 and R.sub.6 being the nitro group or the trifluoro methyl group while the other one is the hydrogen atom.The acid addition salts of said compounds are also disclosed.The above mentioned novel N-amino alkyl indole compounds have a favorable effect upon the motility of the gastro-intestinal tract.The compounds are obtained, for instance, by reacting the alkali metal salts of a corresponding indole compound which is unsubstituted at its nitrogen atom, with a halogeno alkyl amine.

    摘要翻译： 公开了新的N-氨基烷基吲哚化合物。 这些化合物对应于式I的化合物。式中R1表示氢原子，可被苯基取代的具有1至4个碳原子的烷基或乙酰基; R2表示羟基羰基，具有1-4个烷基碳原子的烷氧基羰基，氰基，氨基羰基，具有1-4个烷基碳原子的单烷基氨基羰基或二烷基氨基羰基 具有1至4个烷基碳原子，条件是当R 2是羟基羰基时，则R 1不是氢原子; A表示碳原子数2〜5的亚烷基， R3和R4是相同或不同的取代基，表示氢原子，具有1至4个碳原子的烷基，或者R3和R4是与它们所连接的氮原子一起形成的亚烷基， 5至7名成员; 并且R 5和R 6是相同或不同的取代基，并且表示氢和卤素原子，具有1至3个碳原子的烷基，具有1至3个碳原子的烷氧基，或所述取代基R 5和R 6中的一个是硝基或三氟 甲基，而另一个是氢原子。 还公开了所述化合物的酸加成盐。 上述新型N-氨基烷基吲哚化合物对胃肠道的运动具有有利的作用。 化合物例如通过使在其氮原子上未取代的相应吲哚化合物的碱金属盐与卤代烷基胺反应而获得。