公开(公告)号：US20240238425A1

公开(公告)日：2024-07-18

申请号：US18541015

申请日：2023-12-15

申请人： Pfizer Inc.

发明人： Jan Antoinette Cusi Romero Adams ,  Yotam Ashkenazi ,  Matthew Frank Brown ,  Jason Kenneth Dutra ,  Michelle Renee Garnsey ,  Xinjun Hou ,  Jisun Lee ,  Yajing Lian ,  Deane Milford Nason, II ,  Steven Victor O'Neil ,  Amanda Brooke Pecora ,  Alistair Dean Richardson ,  Matthew Forrest Sammons ,  Yang Wang ,  Ann Sorrentino Wright ,  Jun Xiao ,  Lei Zhang ,  Liying Zhang

IPC分类号： A61K47/55 ,  A61K45/06

CPC分类号： A61K47/55 ,  A61K45/06

摘要： Described herein are 3-fluoro-4-hydroxybenzamide-containing inhibitors and/or degraders, and pharmaceutical compositions containing 3-fluoro-hydroxybenzamide-containing inhibitors and/or degraders. In some embodiments, the 3-fluoro-4-hydroxybenzamide-containing compounds of the disclosure can be used to treat a condition, for example, nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

公开(公告)号：US20240150334A1

公开(公告)日：2024-05-09

申请号：US18482129

申请日：2023-10-06

申请人： Pfizer Inc.

发明人： Jan Antoinette Cusi Romero Adams ,  Bruce Michael Bechle ,  Jason Kenneth Dutra ,  Michelle Renee Garnsey ,  Xinjun Hou ,  Jisun Lee ,  Deane Milford Nason, II ,  Steven Victor O'Neil ,  Danica Antonia Rankic ,  Yang Wang ,  Ann Sorrentino Wright ,  Lei Zhang ,  Liying Zhang ,  David James Edmonds

IPC分类号： C07D413/04 ,  C07D231/56 ,  C07D263/56 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D413/04 ,  C07D231/56 ,  C07D263/56 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D498/04 ,  C07D513/04

摘要： Described herein are compounds of Formula I,




wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.