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公开(公告)号：US20210017172A1
公开(公告)日：2021-01-21
申请号：US16926933
申请日：2020-07-13
申请人： Pfizer Inc.
发明人： Omar Ahmad , Andrew Fensome , Erik Alphie LaChapelle , Ethan Lawrence Fisher , Rayomand J. Unwalla , Jun Xiao , Lei Zhang
IPC分类号： C07D471/04 , A61K31/437
摘要： The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.
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公开(公告)号：US20200002310A1
公开(公告)日：2020-01-02
申请号：US16567675
申请日：2019-09-11
申请人： Pfizer Inc.
发明人： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC分类号： C07D401/12 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D241/20 , C07D475/00
摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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公开(公告)号：US20240238425A1
公开(公告)日：2024-07-18
申请号：US18541015
申请日：2023-12-15
申请人： Pfizer Inc.
发明人： Jan Antoinette Cusi Romero Adams , Yotam Ashkenazi , Matthew Frank Brown , Jason Kenneth Dutra , Michelle Renee Garnsey , Xinjun Hou , Jisun Lee , Yajing Lian , Deane Milford Nason, II , Steven Victor O'Neil , Amanda Brooke Pecora , Alistair Dean Richardson , Matthew Forrest Sammons , Yang Wang , Ann Sorrentino Wright , Jun Xiao , Lei Zhang , Liying Zhang
摘要： Described herein are 3-fluoro-4-hydroxybenzamide-containing inhibitors and/or degraders, and pharmaceutical compositions containing 3-fluoro-hydroxybenzamide-containing inhibitors and/or degraders. In some embodiments, the 3-fluoro-4-hydroxybenzamide-containing compounds of the disclosure can be used to treat a condition, for example, nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
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公开(公告)号：US11339159B2
公开(公告)日：2022-05-24
申请号：US16926933
申请日：2020-07-13
申请人： Pfizer Inc.
发明人： Omar Ahmad , Andrew Fensome , Erik Alphie LaChapelle , Ethan Lawrence Fisher , Rayomand J. Unwalla , Jun Xiao , Lei Zhang
IPC分类号： C07D471/04 , A61K31/437
摘要： The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.
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公开(公告)号：US20160130250A1
公开(公告)日：2016-05-12
申请号：US15000944
申请日：2016-01-19
申请人： PFIZER, INC.
发明人： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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公开(公告)号：US20240109862A1
公开(公告)日：2024-04-04
申请号：US18121809
申请日：2023-03-15
申请人： Pfizer Inc.
发明人： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC分类号： C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
CPC分类号： C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
摘要： The present invention relates to a compound of the formula I
wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.-
公开(公告)号：US20220274986A1
公开(公告)日：2022-09-01
申请号：US17738074
申请日：2022-05-06
申请人： Pfizer Inc.
发明人： Omar Ahmad , Andrew Fensome , Erik Alphie LaChapelle , Ethan Lawrence Fisher , Rayomand J. Unwalla , Jun Xiao , Lei Zhang
IPC分类号： C07D471/04 , A61K31/437
摘要： The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.
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公开(公告)号：US20190047979A1
公开(公告)日：2019-02-14
申请号：US15946117
申请日：2018-04-05
申请人： Pfizer, Inc.
发明人： Michael J. Luzzio , Kevin D. Freeman-Cook , Samit K. Bhattacharya , Matthew M. Hayward , Catherine A. Hulford , Christopher L. Autry , Xumiao Zhao , Jun Xiao , Kendra L. Nelson
IPC分类号： C07D401/12 , C07D475/00 , C07D241/20 , C07D417/14 , C07D417/12 , C07D239/48 , C07D405/14 , C07D403/12 , C07D401/14 , C07D413/14
摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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公开(公告)号：US20220251066A1
公开(公告)日：2022-08-11
申请号：US17458862
申请日：2021-08-27
申请人： Pfizer Inc.
发明人： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC分类号： C07D401/12 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D241/20 , C07D475/00
摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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公开(公告)号：US20170327485A1
公开(公告)日：2017-11-16
申请号：US15492719
申请日：2017-04-20
申请人： Pfizer Inc.
发明人： Michael J. Luzzio , Kevin D. Freeman-Cook , Samit K. Bhattacharya , Matthew M. Hayward , Catherine A. Hulford , Christopher L. Autry , Xumiao Zhao , Jun Xiao , Kendra L. Nelson
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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