公开(公告)号：US20030096958A1

公开(公告)日：2003-05-22

申请号：US10218957

申请日：2002-08-14

申请人： Pfizer Inc.

发明人： Scott P. Kennedy ,  Dexue Sun

IPC分类号： C07K014/435 ,  C07K016/22 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC分类号： C07K14/47 ,  C07K14/705

摘要： The invention is directed to two forms of isolated or purified human NHE2 polypeptide sequences, NHE2-LF and NHE2-SF, as well as the polynucleotide coding sequences that encode the human NHE2-LF and NHE2-SF polypeptides. Also featured are NHE2-LF- and NHE2-SF-related hosts, cell membrane preparations, vectors, and antibodies, as well as methods of using cells recombinantly expressing the human NHE2-LF or NHE2-SF, to identify agents that modulate human NHE activity.

摘要翻译： 本发明涉及两种形式的分离或纯化的人NHE2多肽序列NHE2-LF和NHE2-SF，以及编码人NHE2-LF和NHE2-SF多肽的多核苷酸编码序列。 还特征是NHE2-LF-和NHE2-SF相关宿主，细胞膜制备物，载体和抗体，以及使用重组表达人NHE2-LF或NHE2-SF的细胞的方法来鉴定调节人NHE的试剂 活动。