公开(公告)号：US20240009296A1

公开(公告)日：2024-01-11

申请号：US18347698

申请日：2023-07-06

Applicant: PFIZER INC.

Inventor： Hui Cai ,  Ye Che ,  Fernando Martin Diaz ,  Raquel Munoz-Moreno ,  Alicia Solórzano Quijano ,  Chong Wang

IPC: A61K39/145

CPC classification number: A61K39/145 ,  A61K2039/53

Abstract: Self-amplifying RNA (saRNA) molecules encoding an influenza virus antigen and methods of use thereof are disclosed herein.

公开(公告)号：US20230233671A1

公开(公告)日：2023-07-27

申请号：US18045967

申请日：2022-10-12

Applicant: Pfizer Inc.

Inventor： Eric Matthew Bennett ,  Fernando Martin Diaz ,  Philip Ralph Dormitzer ,  Kathrin Ute Jansen ,  Raquel Munoz-Moreno ,  Alicia Solorzano Quijano

IPC: A61K39/25 ,  A61K47/69 ,  A61K47/10 ,  A61K47/28 ,  A61P37/04

CPC classification number: A61K39/25 ,  A61K47/6929 ,  A61K47/10 ,  A61K47/28 ,  A61P37/04

Abstract: The present disclosure relates to RNA molecules encoding a varicella zoster virus (VZV). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA molecules, RNA-LNPs and compositions for the treatment or prevention of herpes zoster or shingles.