公开(公告)号：US20230357211A1

公开(公告)日：2023-11-09

申请号：US18245039

申请日：2021-09-13

Applicant: Pfizer Inc.

Inventor： Wesley Dewitt CLARK ,  Judith Gail DEAL ,  Brian Matthew SAMAS

IPC: C07D405/14

CPC classification number: C07D405/14 ,  C07B2200/13

Abstract: This invention relates to crystalline and amorphous forms of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-D-threo-pentitol, to pharmaceutical compositions comprising such solid forms, and to use of such solid forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：US20150291604A1

公开(公告)日：2015-10-15

申请号：US14677112

申请日：2015-04-02

Applicant: PFIZER INC.

Inventor： Ping CHEN ,  Hengmiao CHENG ,  Judith Gail DEAL ,  Gary Michael GALLEGO ,  Mehran JALAIE ,  John Charles KATH ,  Suvi Tuula Marjukka ORR ,  Hong SHEN ,  Luke Raymond ZEHNDER

IPC: C07D487/04 ,  A61N5/10 ,  A61K45/06 ,  A61K31/5377 ,  C07F9/6561

CPC classification number: C07D487/04 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10 ,  C07F9/65616

Abstract: The present invention relates to compounds of formula (X) or pharmaceutically acceptable salts thereof, wherein R1-R50, a, b, d, e, f, g, h, i, j, k, l, o, p, q, r, s, t, u, y, and z are defined herein. The novel dihydropyrrolopyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract translation: 本发明涉及式（X）化合物或其药学上可接受的盐，其中R 1 -R 50，a，b，d，e，f，g，h，i，j，k，l，o，p，q， r，s，t，u，y和z在本文中定义。 新型二氢吡咯并嘧啶衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 另外的实施方案涉及含有化合物的药物组合物和使用化合物和组合物治疗哺乳动物异常细胞生长的方法。