公开(公告)号：US20230321212A1

公开(公告)日：2023-10-12

申请号：US18042561

申请日：2021-08-23

Applicant: Pfizer Inc.

Inventor： Annaliesa Sybil Anderson ,  Robert George Konrad Donald ,  Julio Cesar Hawkins ,  Srinivas Kodali ,  Raphael Simon

IPC: A61K39/09 ,  A61P37/04

CPC classification number: A61K39/092 ,  A61P37/04 ,  A61K2039/6031

Abstract: The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.