公开(公告)号：US10815240B2

公开(公告)日：2020-10-27

申请号：US16502703

申请日：2019-07-03

Applicant: Pfizer Inc.

Inventor： Kapildev Kashmirilal Arora ,  Jacob Cole DeForest ,  Andrew Kevern Hills ,  Brian Patrick Jones ,  Kris Nicole Jones ,  Chad Arthur Lewis ,  Anil Mahadeo Rane

IPC: C07D487/04 ,  C07D249/08

Abstract: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.

公开(公告)号：US11254684B2

公开(公告)日：2022-02-22

申请号：US17036849

申请日：2020-09-29

Applicant: Pfizer Inc.

Inventor： Kapildev Kashmirilal Arora ,  Jacob Cole DeForest ,  Andrew Kevern Hills ,  Brian Patrick Jones ,  Kris Nicole Jones ,  Chad Arthur Lewis ,  Anil Mahadeo Rane

IPC: C07D487/04 ,  C07D249/08

Abstract: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.

公开(公告)号：US20210009601A1

公开(公告)日：2021-01-14

申请号：US17036849

申请日：2020-09-29

Applicant: Pfizer Inc.

Inventor： Kapildev Kashmirilal Arora ,  Jacob Cole DeForest ,  Andrew Kevern Hills ,  Brian Patrick Jones ,  Kris Nicole Jones ,  Chad Arthur Lewis ,  Anil Mahadeo Rane

IPC: C07D487/04 ,  C07D249/08

Abstract: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.

公开(公告)号：US20200123159A1

公开(公告)日：2020-04-23

申请号：US16502703

申请日：2019-07-03

Applicant: Pfizer Inc.

Inventor： Kapildev Kashmirilal Arora ,  Jacob Cole DeForest ,  Andrew Kevern Hills ,  Brian Patrick Jones ,  Kris Nicole Jones ,  Chad Arthur Lewis ,  Anil Mahadeo Rane

IPC: C07D487/04 ,  C07D249/08

Abstract: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.

公开(公告)号：US12018031B2

公开(公告)日：2024-06-25

申请号：US17572089

申请日：2022-01-10

Applicant: Pfizer Inc.

Inventor： Kapildev Kashmirilal Arora ,  Jacob Cole DeForest ,  Andrew Kevern Hills ,  Brian Patrick Jones ,  Kris Nicole Jones ,  Chad Arthur Lewis ,  Anil Mahadeo Rane

IPC: C07D487/04 ,  C07D249/08

CPC classification number: C07D487/04 ,  C07D249/08 ,  C07B2200/13

Abstract: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.

公开(公告)号：US20220127274A1

公开(公告)日：2022-04-28

申请号：US17572089

申请日：2022-01-10

Applicant: Pfizer Inc.

Inventor： Kapildev Kashmirilal Arora ,  Jacob Cole DeForest ,  Andrew Kevern Hills ,  Brian Patrick Jones ,  Kris Nicole Jones ,  Chad Arthur Lewis ,  Anil Mahadeo Rane

IPC: C07D487/04 ,  C07D249/08

Abstract: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.

公开(公告)号：US09770441B1

公开(公告)日：2017-09-26

申请号：US15509343

申请日：2015-08-31

Applicant: Pfizer Inc.

Inventor： Kevin Paul Girard ,  Andrew J. Jensen ,  Kris Nicole Jones

IPC: C07D263/57 ,  A61K31/423

CPC classification number: A61K31/423 ,  C07B2200/13 ,  C07D263/57

Abstract: The present invention relates to solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one solid form and to the therapeutic or prophylactic use of such solid forms and compositions.