公开(公告)号：US11059876B2

公开(公告)日：2021-07-13

申请号：US16286158

申请日：2019-02-26

Applicant: Pfizer Inc.

Inventor： Yik Andy Yeung ,  Reid Martin Renny Feldman ,  Ling Hon Matthew Chu ,  Javier Fernando Chaparro Riggers ,  Ivana Djuretic ,  Laura Lin ,  Lidia Mosyak

IPC: C07K14/54 ,  A61K39/395 ,  A61K38/17 ,  A61K38/20 ,  A61K35/17 ,  C07K19/00 ,  A61P35/00 ,  C07K16/32 ,  C07K16/28 ,  C07K14/55 ,  C12N15/62 ,  A61K38/19 ,  A61K45/06

Abstract: The present invention relates to human interleukin 15 (IL-15) variants that have therapeutic and diagnostic use, and methods for making thereof. The present invention also provides fusion proteins comprising a human IL-15 variant. Also provided are methods of stimulating or suppressing immune responses in a mammal, and methods of treating a disorder (e.g., cancer) using the IL-15 variants or the fusion protein of such IL-15 variants.

公开(公告)号：US20210324028A1

公开(公告)日：2021-10-21

申请号：US17356754

申请日：2021-06-24

Applicant: Pfizer Inc.

Inventor： Yik Andy Yeung ,  Reid Martin Renny Feldman ,  Ling Hon Matthew Chu ,  Javier Fernando Chaparro Riggers ,  Ivana Djuretic ,  Laura Lin ,  Lidia Mosyak

IPC: C07K14/54 ,  A61K35/17 ,  C07K19/00 ,  A61P35/00 ,  A61K38/17 ,  C07K16/32 ,  C07K16/28 ,  C07K14/55 ,  C12N15/62 ,  A61K38/19 ,  A61K39/395 ,  A61K38/20

Abstract: The present invention relates to human interleukin 15 (IL-15) variants that have therapeutic and diagnostic use, and methods for making thereof. The present invention also provides fusion proteins comprising a human IL-15 variant. Also provided are methods of stimulating or suppressing immune responses in a mammal, and methods of treating a disorder (e.g., cancer) using the IL-15 variants or the fusion protein of such IL-15 variants.

公开(公告)号：US20190263877A1

公开(公告)日：2019-08-29

申请号：US16286158

申请日：2019-02-26

Applicant: Pfizer Inc.

Inventor： Yik Andy Yeung ,  Reid Martin Renny Feldman ,  Ling Hon Matthew Chu ,  Javier Fernando Chaparro Riggers ,  Ivana Djuretic ,  Laura Lin ,  Lidia Mosyak

IPC: C07K14/54 ,  C07K14/55 ,  A61K35/17 ,  C07K19/00 ,  A61P35/00 ,  A61K38/17 ,  C07K16/32 ,  C07K16/28 ,  C12N15/62

Abstract: The present invention relates to human interleukin 15 (IL-15) variants that have therapeutic and diagnostic use, and methods for making thereof. The present invention also provides fusion proteins comprising a human IL-15 variant. Also provided are methods of stimulating or suppressing immune responses in a mammal, and methods of treating a disorder (e.g., cancer) using the IL-15 variants or the fusion protein of such IL-15 variants.