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公开(公告)号：US20240076386A1
公开(公告)日：2024-03-07
申请号：US18174974
申请日：2023-02-27
申请人： Pfizer Inc.
发明人： James Reasoner Apgar , Sheryl Rubio Bowley , Joanne Elizabeth-Ayriss Elwell , Laura Lin , Jatin Narula , Chuenlei Parng , Debra Denene Pittman , Swapnil Rakhe , Chihyi Vincent Yu
IPC分类号： C07K16/28
CPC分类号： C07K16/2854 , A61K2039/505
摘要： The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to E-selectin. The invention includes uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.
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公开(公告)号：US20190263877A1
公开(公告)日：2019-08-29
申请号：US16286158
申请日：2019-02-26
申请人： Pfizer Inc.
发明人： Yik Andy Yeung , Reid Martin Renny Feldman , Ling Hon Matthew Chu , Javier Fernando Chaparro Riggers , Ivana Djuretic , Laura Lin , Lidia Mosyak
IPC分类号： C07K14/54 , C07K14/55 , A61K35/17 , C07K19/00 , A61P35/00 , A61K38/17 , C07K16/32 , C07K16/28 , C12N15/62
摘要： The present invention relates to human interleukin 15 (IL-15) variants that have therapeutic and diagnostic use, and methods for making thereof. The present invention also provides fusion proteins comprising a human IL-15 variant. Also provided are methods of stimulating or suppressing immune responses in a mammal, and methods of treating a disorder (e.g., cancer) using the IL-15 variants or the fusion protein of such IL-15 variants.
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公开(公告)号：US20210324028A1
公开(公告)日：2021-10-21
申请号：US17356754
申请日：2021-06-24
申请人： Pfizer Inc.
发明人： Yik Andy Yeung , Reid Martin Renny Feldman , Ling Hon Matthew Chu , Javier Fernando Chaparro Riggers , Ivana Djuretic , Laura Lin , Lidia Mosyak
IPC分类号： C07K14/54 , A61K35/17 , C07K19/00 , A61P35/00 , A61K38/17 , C07K16/32 , C07K16/28 , C07K14/55 , C12N15/62 , A61K38/19 , A61K39/395 , A61K38/20
摘要： The present invention relates to human interleukin 15 (IL-15) variants that have therapeutic and diagnostic use, and methods for making thereof. The present invention also provides fusion proteins comprising a human IL-15 variant. Also provided are methods of stimulating or suppressing immune responses in a mammal, and methods of treating a disorder (e.g., cancer) using the IL-15 variants or the fusion protein of such IL-15 variants.
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公开(公告)号：US20150306234A1
公开(公告)日：2015-10-29
申请号：US14638760
申请日：2015-03-04
申请人： Pfizer Inc.
发明人： James Apgar , Debra Pittman , Mark Stahl , Laura Lin , Justin Cohen
IPC分类号： A61K47/48 , A61K38/37 , C07K14/755
CPC分类号： C07K14/755 , A61K38/00 , A61K38/37 , A61K47/61
摘要： The present disclosure provides muteins of FVIII to which a biocompatible polymer may be attached to increase the circulatory half-life of the muteins, as well as conjugates of such muteins and biocompatible polymers.
摘要翻译： 本公开内容提供FVIII的突变蛋白，生物相容性聚合物可以连接到其上，以增加突变蛋白的循环半衰期，以及这些突变蛋白和生物相容性聚合物的缀合物。
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公开(公告)号：US11597770B2
公开(公告)日：2023-03-07
申请号：US17154588
申请日：2021-01-21
申请人： Pfizer Inc.
发明人： James Reasoner Apgar , Sheryl Rubio Bowley , Joanne Elizabeth-Ayriss Elwell , Laura Lin , Jatin Narula , Chuenlei Parng , Debra Denene Pittman , Swapnil Rakhe , Chihyi Vincent Yu
摘要： The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to E-selectin. The invention includes uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.
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公开(公告)号：US20210246213A1
公开(公告)日：2021-08-12
申请号：US17154588
申请日：2021-01-21
申请人： Pfizer Inc.
发明人： James Reasoner Apgar , Sheryl Rubio Bowley , Joanne Elizabeth-Ayriss Elwell , Laura Lin , Jatin Narula , Chuenlei Parng , Debra Denene Pittman , Swapnil Rakhe , Chihyi Vincent Yu
IPC分类号： C07K16/28
摘要： The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to E-selectin. The invention includes uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.
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公开(公告)号：US11059876B2
公开(公告)日：2021-07-13
申请号：US16286158
申请日：2019-02-26
申请人： Pfizer Inc.
发明人： Yik Andy Yeung , Reid Martin Renny Feldman , Ling Hon Matthew Chu , Javier Fernando Chaparro Riggers , Ivana Djuretic , Laura Lin , Lidia Mosyak
IPC分类号： C07K14/54 , A61K39/395 , A61K38/17 , A61K38/20 , A61K35/17 , C07K19/00 , A61P35/00 , C07K16/32 , C07K16/28 , C07K14/55 , C12N15/62 , A61K38/19 , A61K45/06
摘要： The present invention relates to human interleukin 15 (IL-15) variants that have therapeutic and diagnostic use, and methods for making thereof. The present invention also provides fusion proteins comprising a human IL-15 variant. Also provided are methods of stimulating or suppressing immune responses in a mammal, and methods of treating a disorder (e.g., cancer) using the IL-15 variants or the fusion protein of such IL-15 variants.
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公开(公告)号：US10570189B2
公开(公告)日：2020-02-25
申请号：US14638760
申请日：2015-03-04
申请人： Pfizer Inc.
发明人： James Apgar , Debra Pittman , Mark Stahl , Laura Lin , Justin Cohen
IPC分类号： C07K14/755 , A61K38/00 , A61K47/61 , A61K38/37
摘要： The present disclosure provides muteins of FVIII to which a biocompatible polymer may be attached to increase the circulatory half-life of the muteins, as well as conjugates of such muteins and biocompatible polymers.
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