公开(公告)号：US11655252B2

公开(公告)日：2023-05-23

申请号：US17363494

申请日：2021-06-30

Applicant: Pfizer Inc.

Inventor： Brian Stephen Gerstenberger ,  Wenhua Jiao ,  Manjinder Singh Lall ,  Ricardo Lira ,  Mark Edward Schnute

IPC: C07D471/18 ,  A61K45/06

CPC classification number: C07D471/18 ,  A61K45/06 ,  C07B2200/13

Abstract: A compound of formula I:




or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are each independently hydrogen or hydroxy; wherein R1 and R2 are not both hydroxy. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.