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1.
公开(公告)号:US20040121015A1
公开(公告)日:2004-06-24
申请号:US10727217
申请日:2003-12-03
申请人: Pfizer Inc
发明人: Mark B. Chidlaw , Dwayne T. Friesen , Scott M. Herbig , James A.S. Nightingale , Cynthia A. Oksanen , James B. West
IPC分类号: A61K009/24
CPC分类号: A61K31/4985 , A61K9/0004 , A61K9/209 , A61K9/2866 , A61K31/137
摘要: A controlled release delivery composition which can be administered to a high fat use environment such as the human gastrointestinal tract following a high fat meal. The delivery composition is embodied as a core surrounded by an asymmetric polymeric membrane. In a preferred embodiment, the asymmetric polymeric membrane is cellulose acetate.
摘要翻译: 可以在高脂肪膳食之后施用于高脂肪使用环境例如人类胃肠道的控释组合物。 递送组合物被实施为由不对称聚合物膜包围的核心。 在优选的实施方案中,不对称聚合物膜是乙酸纤维素。
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公开(公告)号:US20040175428A1
公开(公告)日:2004-09-09
申请号:US10799536
申请日:2004-03-11
申请人: Pfizer Inc.
发明人: Leah E. Appel , William J. Curatolo , Scott M. Herbig , James A.S. Nightingale , Avinash G. Thombre
IPC分类号: A61K009/24 , A61K009/16 , A61K009/50
CPC分类号: A61K9/0004 , A61K9/146 , A61K9/2077 , A61K9/2086 , A61K9/209
摘要: Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the influx of water to the core so as to cause extrusion of a portion of the core, as well as a method of treating a disease or disorder comprising administering such dosage form to a person.
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公开(公告)号:US20030219489A1
公开(公告)日:2003-11-27
申请号:US10458840
申请日:2003-06-09
申请人: Pfizer Inc.
IPC分类号: A61K031/717 , A61K031/44 , A61K031/19 , A61K031/405
CPC分类号: A61K47/38 , A61J3/02 , A61K9/146 , A61K9/1652 , B01J8/005
摘要: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
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