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    Use of compounds for the inhibition of proteins and UV protection
    2.
    发明申请
    Use of compounds for the inhibition of proteins and UV protection 审中-公开
    使用化合物抑制蛋白质和紫外线防护

    公开(公告)号：US20040248982A1

    公开(公告)日：2004-12-09

    申请号：US10458155

    申请日：2003-06-09

    发明人： Gordon Wayne Dyer

    IPC分类号： A61K031/195 ,  A61K031/19

    CPC分类号： A61Q17/04 ,  A61K8/4926 ,  A61K31/19 ,  A61K31/195

    摘要： The invention treats proteinase-related disorders by interfering with the binding of the metal needed by matrix metalloproteinases, such as PLA-2. The compounds used are known microbial-based chelators of known high solubility. For example, dipicolinic acid has a high affinity to calcium and is soluble in both water and glycerin, as might be expected due to its role in the formation of bacterial endospores. Thus, unlike most chelation agents, the compounds are intended to be permeable enough to cross a vertebrate's cell membrane, a prerequisite for meaningful inhibition of protein-regulated cellular functions such as the inflammatory cascade and accompanying formation of free fatty acids. In addition, because six-ring aromatic chemical structures are inherently durable, it is likely that these compounds will be long-acting, an important attribute because most proteinase-related disorder/diseases are chronic

    摘要翻译： 本发明通过干扰基质金属蛋白酶如PLA-2所需的金属的结合来处理蛋白酶相关病症。 所使用的化合物是已知的高溶解度的已知的微生物基螯合剂。 例如，二吡啶酸对钙具有高亲和力，并且由于其在细菌内生孢子的形成中的作用而可能预期可溶于水和甘油两者。 因此，与大多数螯合剂不同，化合物旨在足够渗透以穿过脊椎动物的细胞膜，这是有意义地抑制蛋白质调节的细胞功能例如炎症级联和伴随形成游离脂肪酸的先决条件。 另外，因为六环芳族化学结构本质上是耐用的，所以这些化合物很可能是长效的，因为大多数蛋白酶相关的病症/疾病是慢性的

    Compounds and methods for the modulation of cd154
    3.
    发明申请
    Compounds and methods for the modulation of cd154 有权
    cd154调节化合物和方法

    公开(公告)号：US20040248813A1

    公开(公告)日：2004-12-09

    申请号：US10476237

    申请日：2004-07-08

    发明人： Lisa Alaimo ,  Veronica Alves ,  Patrick Andre ,  David Phillips ,  Srinivasa Prasad ,  Denisa D. Wagner

    IPC分类号： A61K038/04 ,  A61K031/19

    CPC分类号： A61K38/57 ,  A61K31/00 ,  A61K38/12 ,  A61K2300/00

    摘要： The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved in an inflammatory response. The present invention also relates to methods useful for identifying such compounds. The present invention also relates to the treatment of platelets for transfusion with metalloproteinase inhibitors to treat or prevent inflammation. The present invention also includes compositions and methods to treat injury and disease related to such biological processes.

    摘要翻译： 本发明涉及能够调节CD154动员并且可用于稳定血栓形成过程并减少参与炎性反应的细胞活化的化合物。 本发明还涉及用于鉴定这些化合物的方法。 本发明还涉及用金属蛋白酶抑制剂输血的血小板治疗或预防炎症。 本发明还包括治疗与这种生物过程相关的损伤和疾病的组合物和方法。

    Ancrod irradiated, impregnated or coated sutures and other first aid or wound management bandaging materials for minimizing scarring and/or preventing excessive scar formation
    4.
    发明申请
    Ancrod irradiated, impregnated or coated sutures and other first aid or wound management bandaging materials for minimizing scarring and/or preventing excessive scar formation 审中-公开
    用于最小化瘢痕形成和/或防止过度瘢痕形成的安瓿照射，浸渍或涂覆的缝合线和其它急救或伤口管理包扎材料

    公开(公告)号：US20040224006A1

    公开(公告)日：2004-11-11

    申请号：US10829143

    申请日：2004-04-21

    发明人： Samn Raffaniello

    IPC分类号： A61K038/48 ,  A61K031/515 ,  A61K031/19

    CPC分类号： A61K38/482 ,  A61K31/00 ,  A61K31/19 ,  A61K31/515 ,  A61K38/166 ,  A61K38/49 ,  A61L15/44 ,  A61L17/005 ,  A61L2300/254 ,  A61L2300/30 ,  A61L2300/42

    摘要： A method for minimizing scarring and preventing excessive scar formation at an injury site is disclosed. The method involves the topical and/or local application of a therapeutically effective amount of a defibrinogenating agent or of a fibrinolytic agent that may be delivered in an appropriate vehicle in a controlled- or timed-release manner. In accordance with the principles of the invention, the defibrinogenating agent or fibrinolytic agent is applied as a coating on, or is irradiated or impregnated into or onto a delivery vehicle such as, for example, sutures, dissolvable sutures, bandages, gauze pads, or other types of first aid bandaging materials. Such application may take the form of a controlled- or timed-release aspect of either the vehicle, the delivery material or the therapeutic agent, such that the release of the therapeutic agent may be regulated to produce an appropriate therapeutic pattern or defibrinogenation or fibrinolysis. In a preferred aspect of the invention, the defibrinogenating agent is ancrod, and the mode of application is as ancrod-coated sutures.

    摘要翻译： 公开了一种减少瘢痕形成并防止损伤部位过度瘢痕形成的方法。 该方法涉及局部和/或局部施用治疗有效量的去纤维蛋白原化剂或纤维蛋白溶解剂，其可以以受控或定时释放的方式递送于合适的载体中。 根据本发明的原理，脱纤维蛋白原化剂或纤维蛋白溶解剂作为涂层施用于或被照射或浸渍到递送载体中或载体上，例如缝合线，可溶解缝线，绷带，纱布垫或 其他类型的急救包扎材料。 这种应用可以采取车辆，递送材料或治疗剂的受控制或定时释放方面的形式，使得可以调节治疗剂的释放以产生适当的治疗模式或去纤维蛋白原化或纤维蛋白溶解。 在本发明的优选方面，除纤维蛋白原化剂是辅助的，并且应用的方式是作为辅助涂层的缝合线。

    Topical treatment of dermatological disorders associated with reactive or dilated blood vessels
    5.
    发明申请
    Topical treatment of dermatological disorders associated with reactive or dilated blood vessels 审中-公开
    与反应性或扩张型血管相关的皮肤病的局部治疗

    公开(公告)号：US20040220259A1

    公开(公告)日：2004-11-04

    申请号：US10817479

    申请日：2004-04-02

    发明人： Ruey J. Yu ,  Eugene J. Van Scott

    IPC分类号： A61K031/366 ,  A61K031/19

    CPC分类号： A61K31/70 ,  A61K8/365 ,  A61K45/06 ,  A61Q19/00 ,  A61K2300/00

    摘要： The invention provides a method of topically treating a dermatological disorder. The method includes topically applying a therapeutically effective amount of a cosmetic or dermatological composition to an affected area of the skin. The composition includes at least one compound that is (i) a polyhydroxy-aldonic acid, (ii) a polyhydroxy-aldonic lactone, (iii) a polyhydroxy-alduronic acid, (iv) a polyhydroxy-alduronic lactone, (v) a polyhydroxy-aldaric acid; (vi) a polyhydroxy-aldaric lactone, and (vii) an organic acid lactone having two or more hydroxyl or ketohydroxyl groups. The dermatological disorder treated is one associated with reactive or dilated blood vessels. Also included in the invention are methods of treating dermatological disorders associated with reactive blood vessels that include topical application of a therapeutically effective amount of a composition. The composition includes at least one compound selected from a compound represented by formula (I): 1 by formula (II): 2 and by formula (III) 3 and a lactone derived from an organic acid having two or more hydroxyl or ketohydroxyl groups.

    摘要翻译： 本发明提供了一种局部治疗皮肤病的方法。 该方法包括将治疗有效量的化妆品或皮肤病学组合物局部施用于皮肤的受影响区域。 组合物包括至少一种化合物，其为（i）多羟基 - 醛糖酸，（ii）多羟基 - 醛糖内酯，（iii）多羟基 - 醛糖醛酸，（iv）多羟基 - 醛糖醛酸内酯，（v）多羟基 - 醛糖醛酸内酯 醛酸 （vi）多羟基 - 醛缩酮内酯，和（vii）具有两个或多个羟基或酮羟基的有机酸内酯。 所治疗的皮肤病是与反应性或扩张型血管相关的疾病。 本发明还包括治疗与反应性血管相关的皮肤病学障碍的方法，其包括局部施用治疗有效量的组合物。 该组合物包括选自式（I）表示的化合物：式（II）：和式（III）中的至少一种化合物和衍生自具有两个或多个羟基或酮羟基的有机酸的内酯。

    Carbamic acid compounds comprising an ether linkage as hdac inhibitors
    6.
    发明申请
    Carbamic acid compounds comprising an ether linkage as hdac inhibitors 失效
    包含醚键的氨基甲酸化合物作为hdac抑制剂

    公开(公告)号：US20040198830A1

    公开(公告)日：2004-10-07

    申请号：US10381794

    申请日：2003-07-28

    发明人： Clare J. Watkins ,  Maria Rosario Romero-Martin ,  Paul W Finn ,  Ivars Kalvinsh ,  Einars Loza ,  Daina Lolya ,  Igor Starchenkov ,  Rasma M Bokaldere ,  Valentina Semenikhina ,  C. John Harris ,  James E.S. Duffy

    IPC分类号： A61K031/19 ,  C07C259/04

    CPC分类号： C07C259/06 ,  C07C323/60

    摘要： This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula(l) wherein: A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is an amide linkage selected from: nullNR1C(nullO)null and nullC(nullO)NR1null; R1 is an amido substituent; X is an ether heteroatom, and is nullOnull or nullSnull; and, R2 and R3 are each independently an ether group; and pharmaceutically acceptable salts, solvates, amides, esters, ether chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis. 1

    摘要翻译： 本发明涉及某些抑制HDAC活性的活性氨基甲酸化合物，其具有下式（I）：其中A为芳基; Q 1是共价键或芳基前导基团; J是选自以下的酰胺键：-NR 1 C（= O） - 和-C（= O）NR 1 - ; R1是酰氨基取代基; X是醚杂原子，并且是-O-或-S-; R 2和R 3各自独立地为醚基; 和其药学上可接受的盐，溶剂合物，酰胺，酯，醚化学保护形式及其前药。 本发明还涉及包含这种化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制HDAC，并且例如抑制增殖性疾病如癌症和牛皮癣。

    Dietary plans based on calcium
    9.
    发明申请
    Dietary plans based on calcium 审中-公开
    基于钙的膳食计划

    公开(公告)号：US20040197424A1

    公开(公告)日：2004-10-07

    申请号：US10827297

    申请日：2004-04-20

    申请人： University of Tennessee Research Foundation

    发明人： Michael B. Zemel ,  Hang Shi ,  Paula C. Zemel

    IPC分类号： A61K033/06 ,  A61K031/19

    CPC分类号： A61K31/00 ,  A23L33/16 ,  A23L33/30 ,  Y10S514/905

    摘要： The subject invention provides methods of inducing the loss of adipose tissue by providing a diet high in calcium. In one aspect of the invention, the calcium is provided in the form of dairy products. In yet another aspect of the invention, calcium is provided in the form of a dietary supplement, such as calcium carbonate, of vitamin supplements. Methods of suppressing nullCa2nullnulli levels in individuals are also provided. The subject invention also provides methods of stimulating lipolysis, inhibiting lipogenesis, and increasing the expression of white adipose tissue uncoupling protein 2 (UCP2). The subject invention also provides methods of increasing the core temperature of an individual.

    摘要翻译： 本发明提供通过提供高钙饮食来诱导脂肪组织损失的方法。 在本发明的一个方面，钙以乳制品的形式提供。 在本发明的另一方面，钙以维生素补充剂的膳食补充剂如碳酸钙的形式提供。 还提供了抑制个体中[Ca 2+] i水平的方法。 本发明还提供了刺激脂肪分解，抑制脂肪生成并增加白色脂肪组织解偶联蛋白2（UCP2）的表达的方法。 本发明还提供了增加个体的核心温度的方法。

    Materials and methods for regulating body weight in non-human animals
    10.
    发明申请
    Materials and methods for regulating body weight in non-human animals 审中-公开
    用于调节非人动物体重的材料和方法

    公开(公告)号：US20040197385A1

    公开(公告)日：2004-10-07

    申请号：US10827301

    申请日：2004-04-20

    申请人： University of Tennessee Research Foundation

    发明人： Michael B. Zemel ,  Hang Shi ,  Paula C. Zemel

    IPC分类号： A61K031/19 ,  A23K001/165

    CPC分类号： A61K31/00 ,  A23L33/16 ,  A23L33/30 ,  Y10S514/905

    摘要： The subject invention provides methods of inducing the loss of adipose tissue by providing a diet high in calcium. In one aspect of the invention, the calcium is provided in the form of dairy products. In yet another aspect of the invention, calcium is provided in the form of a dietary supplement, such as calcium carbonate, of vitamin supplements. Methods of suppressing nullCa2nullnulli levels in individuals are also provided. The subject invention also provides methods of stimulating lipolysis, inhibiting lipogenesis, and increasing the expression of white adipose tissue uncoupling protein 2 (UCP2). The subject invention also provides methods of increasing the core temperature of an individual.

    摘要翻译： 本发明提供通过提供高钙饮食来诱导脂肪组织损失的方法。 在本发明的一个方面，钙以乳制品的形式提供。 在本发明的另一方面，钙以维生素补充剂的膳食补充剂如碳酸钙的形式提供。 还提供了抑制个体中[Ca 2+] i水平的方法。 本发明还提供了刺激脂肪分解，抑制脂肪生成并增加白色脂肪组织解偶联蛋白2（UCP2）的表达的方法。 本发明还提供了增加个体的核心温度的方法。