公开(公告)号：US20230383324A1

公开(公告)日：2023-11-30

申请号：US18249411

申请日：2021-10-19

Applicant: Pfizer Inc.

Inventor： Elizabeth BARANYI ,  Wei CHEN ,  Zecheng CHEN ,  Justin Keith MORAN ,  Yonghui YUAN

IPC: C12P19/04

CPC classification number: C12P19/04 ,  C12R2001/46

Abstract: The present invention relates to methods for purifying bacterial polysaccharides, in particular for removing impurities from cellular lysates of bacteria producing polysaccharides.

公开(公告)号：US20180171018A1

公开(公告)日：2018-06-21

申请号：US15878344

申请日：2018-01-23

Applicant: PFIZER INC.

Inventor： Tracy Chia-Chien KUO ,  Javier Fernando CHAPARRO RIGGERS ,  Wei CHEN ,  Amy Shaw-Ru CHEN ,  Edward Derrick PASCUA ,  Thomas John VAN BLARCOM ,  Leila Marie BOUSTANY ,  Weihsien HO ,  Yik Andy YEUNG ,  Pavel STROP ,  Arvind RAJPAL

IPC: C07K16/28 ,  A61K39/395 ,  A61K47/68 ,  A61K31/454 ,  A61K31/69 ,  A61K31/704 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K31/454 ,  A61K31/69 ,  A61K31/704 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6801 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92 ,  A61K2300/00

Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.

公开(公告)号：US20210188991A1

公开(公告)日：2021-06-24

申请号：US17129833

申请日：2020-12-21

Applicant: PFIZER INC.

Inventor： Tracy Chia-Chien KUO ,  Javier Fernando CHAPARRO RIGGERS ,  Wei CHEN ,  Amy Shaw-Ru CHEN ,  Edward Derrick PASCUA ,  Thomas John VAN BLARCOM ,  Leila Marie BOUSTANY ,  Weihsien HO ,  Yik Andy YEUNG ,  Pavel STROP ,  Arvind RAJPAL

IPC: C07K16/28 ,  A61K39/395 ,  A61K31/454 ,  A61K31/704 ,  A61K31/69 ,  A61K47/68

Abstract: The present invention relates bispecific antibodies that specific binds to BCMA (B-Cell Maturation Antigen) and CD3 (Cluster of Differentiation 3). Method of making the bispecific antibodies and method of using the bispecific antibodies for the treatment of multiple myeloma are also provided.

公开(公告)号：US20240018252A1

公开(公告)日：2024-01-18

申请号：US18456399

申请日：2023-08-25

Applicant: PFIZER INC.

Inventor： Tracy Chia-Chien KUO ,  Javier Fernando CHAPARRO RIGGERS ,  Wei CHEN ,  Amy Shaw-Ru CHEN ,  Edward Derrick PASCUA ,  Thomas John VAN BLARCOM ,  Leila Marie BOUSTANY ,  Weihsien HO ,  Yik Andy YEUNG ,  Pavel STROP ,  Arvind RAJPAL

IPC: C07K16/28 ,  A61K31/454 ,  A61K39/395 ,  A61K38/07 ,  A61P35/00 ,  A61K31/704

CPC classification number: C07K16/2878 ,  C07K16/2809 ,  A61K31/454 ,  A61K39/3955 ,  A61K38/07 ,  A61P35/00 ,  A61K31/704 ,  C07K2317/31 ,  A61K39/00

Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.

公开(公告)号：US20180298108A1

公开(公告)日：2018-10-18

申请号：US16017974

申请日：2018-06-25

Applicant: PFIZER INC.

Inventor： Tracy Chia-Chien KUO ,  Javier Fernando CHAPARRO RIGGERS ,  Wei CHEN ,  Amy Shaw-Ru CHEN ,  Edward Derrick PASCUA ,  Thomas John VAN BLARCOM ,  Leila Marie BOUSTANY ,  Weihsien HO ,  Yik Andy YEUNG ,  Pavel STROP ,  Arvind RAJPAL

IPC: C07K16/28 ,  A61K39/395 ,  A61K31/704 ,  A61K31/454 ,  A61K47/68

Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.

公开(公告)号：US20210054087A1

公开(公告)日：2021-02-25

申请号：US17005073

申请日：2020-08-27

Applicant: PFIZER INC.

Inventor： Tracy Chia-Chien KUO ,  Javier Fernando CHAPARRO RIGGERS ,  Wei CHEN ,  Amy Shaw-Ru CHEN ,  Edward Derrick PASCUA ,  Thomas John VAN BLARCOM ,  Leila Marie BOUSTANY ,  Weihsien HO ,  Yik Andy YEUNG ,  Pavel STROP ,  Arvind RAJPAL

IPC: C07K16/28 ,  A61K39/395 ,  A61K31/454 ,  A61K31/704 ,  A61K31/69 ,  A61K47/68

Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.

公开(公告)号：US20160297885A1

公开(公告)日：2016-10-13

申请号：US15085644

申请日：2016-03-30

Applicant: PFIZER INC.

Inventor： Tracy Chia-Chien KUO ,  Javier Fernando CHAPARRO RIGGERS ,  Wei CHEN ,  Amy Shaw-Ru CHEN ,  Edward Derrick PASCUA ,  Thomas John VAN BLARCOM ,  Leila Marie BOUSTANY ,  Weihsien HO ,  Yik Andy YEUNG ,  Pavel STROP ,  Arvind RAJPAL

IPC: C07K16/28 ,  A61K31/704 ,  A61K38/07 ,  A61K38/05 ,  A61K39/395 ,  A61K31/454

CPC classification number: C07K16/2878 ,  A61K31/454 ,  A61K31/69 ,  A61K31/704 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6801 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92 ,  A61K2300/00

Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.

Abstract translation: 本发明涉及特异性结合BCMA（B细胞成熟抗原）和/或CD3（分化群3）的抗体，例如全长抗体或其抗原结合片段。 本发明还涉及包含BCMA抗体的抗体缀合物（例如，抗体 - 药物偶联物），包含BCMA抗体的组合物，以及使用BCMA抗体及其缀合物治疗与表达BCMA的细胞相关的病症的方法（例如癌症或 自身免疫性疾病）。 本发明还涉及特异性结合CD3和肿瘤细胞抗原的异源多聚体抗体（例如，特异性结合CD3和BCMA的双特异性抗体）。 还提供了包含这种异源多聚体抗体的组合物，用于产生和纯化此类异二聚体抗体的方法及其在诊断和治疗中的应用。