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公开(公告)号：US20160271270A1
公开(公告)日：2016-09-22
申请号：US15070549
申请日：2016-03-15
Applicant: Pfizer Inc.
Inventor： Andreas MADERNA , Chakrapani SUBRAMANYAM , Lawrence N. TUMEY , Zecheng CHEN , Jeffrey M. CASAVANT
IPC: A61K47/48 , C07F9/6561 , C07K16/32 , C07K5/09 , C07B59/00 , C07K16/28 , C07D519/00 , C07K5/062
CPC classification number: C07K16/32 , A61K47/65 , A61K47/6803 , A61K47/6807 , A61K47/6849 , A61K47/6863 , A61K47/6865 , A61K47/6869 , A61K47/6871 , C07B59/002 , C07B2200/05 , C07D495/04 , C07D519/00 , C07F9/6561 , C07K5/06052 , C07K5/0815 , C07K16/2803 , C07K16/2866
Abstract: The present invention is directed to novel bifunctional CTI-CTI and CBI-CTI dimers of the formula: F1-L1-T-L2-F2 where F1, L1, T, L2 and F2 are as defined herein, useful for the treatment for proliferative diseases, where the inventive dimers can function as stand-alone drugs, payloads in antibody-drug-conjugates (ADCs), and linker-payload compounds useful in connection with the production or administration of such ADCs; and to compositions including the aforementioned dimers, linker-payloads and ADCs, and methods for using these dimers, linker-payloads and ADCs, to treat pathological conditions including cancer.
Abstract translation: 其中F1，L1，T，L2和F2如本文所定义，可用于治疗增殖性疾病，其中本发明的二聚体可用作独立药物，抗体 - 药物共轭物（ADC）中的有效载荷和接头有效载体 可用于生产或管理此类ADC的化合物; 以及包含上述二聚体，连接物有效载体和ADC的组合物，以及使用这些二聚体，连接体有效载体和ADC的方法来治疗包括癌症在内的病理状况。
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公开(公告)号：US20210061923A1
公开(公告)日：2021-03-04
申请号：US17091097
申请日：2020-11-06
Applicant: PFIZER INC.
Inventor： Andreas MADERNA , Chakrapani SUBRAMANYAM , Lawrence N. TUMEY , Zecheng CHEN , Jeffrey M. CASAVANT
IPC: C07K16/32 , C07D519/00 , C07F9/6561 , C07K5/062 , C07K5/09 , C07B59/00 , C07K16/28 , C07D495/04 , A61K47/68 , A61K47/65
Abstract: The present invention is directed to novel bifunctional CTI-CTI and CBI-CTI dimers of the formula: F1-L1-T-L2-F2 where F1, L1, T, L2 and F2 are as defined herein, useful for the treatment for proliferative diseases, where the inventive dimers can function as stand-alone drugs, payloads in antibody-drug-conjugates (ADCs), and linker-payload compounds useful in connection with the production or administration of such ADCs; and to compositions including the aforementioned dimers, linker-payloads and ADCs, and methods for using these dimers, linker-payloads and ADCs, to treat pathological conditions including cancer.
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Patent Agency Ranking
公开(公告)号：US20180339060A1
公开(公告)日：2018-11-29
申请号：US16053344
申请日：2018-08-02
Applicant: PFIZER INC.
Inventor： Andreas MADERNA , Matthew David DOROSKI , Zecheng CHEN , Hud Lawrence RISLEY , Jeffrey Michael CASAVANT , Christopher John O'DONNELL , Alexander M. PORTE , Chakrapani SUBRAMANYAM
IPC: A61K47/68 , C07K9/00 , C07K5/06 , C07H17/02 , C07F9/6561 , C07D487/04 , C07D417/14 , C07D409/14 , C07D405/14 , C07D401/14 , A61K38/06 , A61K38/05 , A61K31/7056 , A61K31/675 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/407 , A61K31/404 , C07K5/08
CPC classification number: A61K47/6851 , A61K31/404 , A61K31/407 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/675 , A61K31/7056 , A61K38/05 , A61K38/06 , A61K47/6803 , A61K47/6807 , A61K47/6811 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07F9/6561 , C07H17/02 , C07K5/06 , C07K5/08 , C07K9/003
Abstract: Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions.
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公开(公告)号：US20230383324A1
公开(公告)日：2023-11-30
申请号：US18249411
申请日：2021-10-19
Applicant: Pfizer Inc.
Inventor： Elizabeth BARANYI , Wei CHEN , Zecheng CHEN , Justin Keith MORAN , Yonghui YUAN
IPC: C12P19/04
CPC classification number: C12P19/04 , C12R2001/46
Abstract: The present invention relates to methods for purifying bacterial polysaccharides, in particular for removing impurities from cellular lysates of bacteria producing polysaccharides.
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公开(公告)号：US20150209445A1
公开(公告)日：2015-07-30
申请号：US14605697
申请日：2015-01-26
Applicant: Pfizer Inc.
Inventor： Andreas MADERNA , Matthew David DOROSKI , Zecheng CHEN , Hud Lawrence RISLEY , Jeffrey Michael CASAVANT , Christopher John O'DONNELL , Alexander M. PORTE , Chakrapani SUBRAMANYAM
IPC: A61K47/48 , A61K31/404 , A61K31/4439 , C07D401/14 , C07D409/14 , A61K31/675 , C07F9/6561 , A61K31/454 , A61K31/7056 , C07H17/02 , C07D417/14 , A61K31/433 , A61K31/407 , C07D487/04 , C07K5/08 , C07K5/06 , C07K9/00 , A61K38/05 , A61K38/06 , C07D405/14
CPC classification number: A61K47/48384 , A61K31/404 , A61K31/407 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/675 , A61K31/7056 , A61K38/05 , A61K38/06 , A61K47/6803 , A61K47/6807 , A61K47/6811 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07F9/6561 , C07H17/02 , C07K5/06 , C07K5/08 , C07K9/003
Abstract: Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions.
Abstract translation: 包含基于CBI和/或CPI的亚单位的细胞毒性二聚体，包含这种二聚体的抗体药物偶联物，以及使用该二聚体治疗癌症和其它病症的方法。
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公开(公告)号：US20130315865A1
公开(公告)日：2013-11-28
申请号：US13950584
申请日：2013-07-25
Applicant: PFIZER INC.
Inventor： Aranapakam Mudumbai VENKATESAN , Zecheng CHEN , Christoph Martin DEHNHARDT , Osvaldo DOS SANTOS , Efren Guillermo DELOS SANTOS , Arie ZASK , Jeroen Cunera VERHEIJEN , Joshua Aaron KAPLAN , David James RICHARD , Semiramis AYRAL-KALOUSTIAN , Tarek Suhayl MANSOUR , Ariamala GOPALSAMY , Kevin Joseph CURRAN , Mengxiao SHI
IPC: A61K31/5377 , A61K45/06 , C07D413/14
CPC classification number: C07D401/12 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D451/06 , C07D453/02 , C07D491/113 , C07D498/08
Abstract: Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
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公开(公告)号：US20130109670A1
公开(公告)日：2013-05-02
申请号：US13718928
申请日：2012-12-18
Applicant: PFIZER INC.
Inventor： Aranapakam Mudumbai VENKATESAN , Zecheng CHEN , Christoph Martin DEHNHARDT , Osvaldo DOS SANTOS , Efren Guillermo DELOS SANTOS , Arie ZASK , Jeroen Cunera VERHEIJEN , Joshua Aaron KAPLAN , David James RICHARD , Semiramis AYRAL-KALOUSTIAN , Tarek Suhayl MANSOUR , Ariamala GOPALSAMY , Kevin Joseph CURRAN , Mengxiao SHI
IPC: C07D498/08 , C07D491/113 , C07D413/14
CPC classification number: C07D401/12 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D451/06 , C07D453/02 , C07D491/113 , C07D498/08
Abstract: Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
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