公开(公告)号：US20220251036A1

公开(公告)日：2022-08-11

申请号：US17629543

申请日：2020-07-24

申请人： PHARMAXIS LTD.

发明人： Dieter Wolfgang HAMPRECHT ,  Alison Dorothy FINDLAY ,  Craig Ivan TURNER ,  Mandar DEODHAR ,  Angelique Elsa GRECO ,  Wolfgang JAROLIMEK ,  Wenbin ZHOU

IPC分类号： C07C317/32 ,  C07C317/28 ,  C07C317/20 ,  C07D279/12 ,  C07D215/36 ,  C07C317/36 ,  C07B59/00 ,  C07B45/04 ,  C07D209/48 ,  C07D295/116 ,  C07D307/64 ,  C07D333/34

摘要： The present invention relates to methods for preparing a variety of difluorohaloallylamine derivatives. The present invention also relates to novel difluorohaloallylamine derivatives that are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for the treatment of a variety of indications, e.g., fibrosis, cancer and/or scarring in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as uses thereof.

公开(公告)号：US20210353571A1

公开(公告)日：2021-11-18

申请号：US17265402

申请日：2019-08-02

申请人： Pharmaxis Ltd.

发明人： Alison Dorothy FINDLAY ,  Craig Ivan TURNER ,  Mandar DEODHAR ,  Jonathan Stuart FOOT ,  Wolfgang JAROLIMEK ,  Wenbin ZHOU ,  Alberto BUSON ,  Angelique Elsa GRECO

IPC分类号： A61K31/18 ,  A61P17/02 ,  A61P35/00 ,  A61P19/04 ,  A61P35/04 ,  C07C311/29 ,  C07C317/32 ,  C07D213/71 ,  C07D215/36 ,  C07D277/64 ,  C07D209/08 ,  A61K31/145 ,  A61K31/4409 ,  A61K31/47

摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.