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1.发明授权公开(公告)号：US10717734B2
公开(公告)日：2020-07-21
申请号：US16076985
申请日：2017-02-10
申请人： PHARMAXIS LTD.
发明人： Alison Dorothy Findlay , Craig Ivan Turner , Mandar Deodhar , Jonathan Stuart Foot , Wolfgang Jarolimek , Wenbin Zhou , Alan Duncan Robertson
IPC分类号： C07D471/04 , C07D487/04 , A61K45/06 , C07D209/42 , A61P1/16 , A61P13/12 , A61P11/00 , A61K31/4025 , A61K31/4045 , A61K31/41 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/506 , C07D209/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/10 , A61K31/5025 , A61K31/519 , C07D209/20 , C07D209/36
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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2.发明申请公开(公告)号：US20190119269A1
公开(公告)日：2019-04-25
申请号：US16076985
申请日：2017-02-10
申请人： PHARMAXIS LTD.
发明人： Alison Dorothy Findlay , Craig Ivan Turner , Mandar Deodhar , Jonathan Stuart Foot , Wolfgang Jarolimek , Wenbin Zhou , Alan Duncan Robertson
IPC分类号： C07D471/04 , A61K45/06 , A61K31/437 , C07D209/20 , A61K31/4045 , C07D209/36 , C07D487/04 , A61K31/5025 , A61K31/519 , A61P1/16
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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公开(公告)号：US20230321075A1
公开(公告)日：2023-10-12
申请号：US18131183
申请日：2023-04-05
申请人： Pharmaxis Ltd.
发明人： Wolf-Karsten Hofmann , Daniel Nowak , Vladimir Ryabov , Qingyu Xu , Eva Altrock
IPC分类号： A61K31/47 , A61K31/706 , A61P35/00 , A61P35/02
CPC分类号： A61K31/47 , A61K31/706 , A61P35/00 , A61P35/02
摘要： Lysyl oxidase (LOX) inhibitors, lysyl oxidase-like (LOXL) inhibitors, or pharmaceutically acceptable salts thereof and methods for the treatment of myeloid malignancies, comprising administering a therapeutically effective amount of those inhibitors alone or optionally in combination with a second therapeutic agent.
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公开(公告)号：US20220251036A1
公开(公告)日：2022-08-11
申请号：US17629543
申请日：2020-07-24
申请人： PHARMAXIS LTD.
发明人： Dieter Wolfgang HAMPRECHT , Alison Dorothy FINDLAY , Craig Ivan TURNER , Mandar DEODHAR , Angelique Elsa GRECO , Wolfgang JAROLIMEK , Wenbin ZHOU
IPC分类号： C07C317/32 , C07C317/28 , C07C317/20 , C07D279/12 , C07D215/36 , C07C317/36 , C07B59/00 , C07B45/04 , C07D209/48 , C07D295/116 , C07D307/64 , C07D333/34
摘要： The present invention relates to methods for preparing a variety of difluorohaloallylamine derivatives. The present invention also relates to novel difluorohaloallylamine derivatives that are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for the treatment of a variety of indications, e.g., fibrosis, cancer and/or scarring in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as uses thereof.
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5.发明授权公开(公告)号：US11098045B2
公开(公告)日：2021-08-24
申请号：US16899116
申请日：2020-06-11
申请人： PHARMAXIS LTD.
发明人： Alison Dorothy Findlay , Craig Ivan Turner , Mandar Deodhar , Jonathan Stuart Foot , Wolfgang Jarolimek , Wenbin Zhou , Alan Duncan Robertson
IPC分类号： C07D471/04 , C07D487/04 , A61K45/06 , C07D209/42 , A61P1/16 , A61P13/12 , A61P11/00 , A61K31/4025 , A61K31/4045 , A61K31/41 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/506 , C07D209/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/10 , A61K31/5025 , A61K31/519 , C07D209/20 , C07D209/36
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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6.发明申请公开(公告)号：US20200317666A1
公开(公告)日：2020-10-08
申请号：US16899116
申请日：2020-06-11
申请人： PHARMAXIS LTD.
发明人： Alison Dorothy Findlay , Craig Ivan Turner , Mandar Deodhar , Jonathan Stuart Foot , Wolfgang Jarolimek , Wenbin Zhou , Alan Duncan Robertson
IPC分类号： C07D471/04 , C07D487/04 , A61K45/06 , C07D209/42 , A61P1/16 , A61P13/12 , A61P11/00 , A61K31/4025 , A61K31/4045 , A61K31/41 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/506 , C07D209/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/10 , A61K31/5025 , A61K31/519 , C07D209/20 , C07D209/36
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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公开(公告)号：US20200069648A1
公开(公告)日：2020-03-05
申请号：US16490220
申请日：2018-03-02
申请人： Pharmaxis Ltd.
发明人： Alison Dorothy FINDLAY , Craig Ivan TURNER , Mandar DEODHAR , Jonathan Stuart FOOT , Wenbin ZHOU , Wolfgang JAROLIMEK , Alan Duncan ROBERTSON
IPC分类号： A61K31/4155 , C07D231/12 , A61K31/415 , C07D231/14 , C07D231/16 , A61K45/06 , A61P1/16 , A61K31/5377 , C07D231/18 , C07D401/06 , A61K31/4439
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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公开(公告)号：US20230349907A1
公开(公告)日：2023-11-02
申请号：US17797502
申请日：2021-02-05
申请人： Pharmaxis Ltd.
发明人： Alison Dorothy Findlay , Craig Ivan Turner , Mandar Deodhar , Jonathan Stuart Foot , Wolfgang Jarolimek , Heidi Schilter Sambade , Wenbin Zhou , Lara Anne Perryman
IPC分类号： G01N33/573 , C07K16/40 , C07D495/04 , C07D519/00
CPC分类号： G01N33/573 , C07K16/40 , C07D495/04 , C07D519/00 , G01N2333/90638
摘要： The present invention relates to novel bioprobes which are capable of binding to certain amine oxidase enzymes. These bioprobes are useful in methods of detecting and determining the concentration of certain amine oxidase enzymes in a sample as well as in methods for the quantitative assessment of inhibition of certain amine oxidases.
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公开(公告)号：US20230257342A1
公开(公告)日：2023-08-17
申请号：US18012540
申请日：2021-06-25
申请人： Pharmaxis Ltd.
发明人： Alan Duncan Robertson , Alison Dorothy Findlay , Alberto Buson , Craig Ivan Turner , Dieter Wolfgang Hamprecht , Jonathan Stuart Foot , Mandar Deodhar , Wolfgang Jarolimek , Serena Becchi , Bernard Walter Balleine , Marcella Canton , Libero Vitiello , Bert Blaauw
IPC分类号： C07C255/54 , A61P9/00 , A61P21/00
CPC分类号： C07C255/54 , A61P9/00 , A61P21/00
摘要： The present invention relates to novel compounds which are capable of inhibiting semicarbazide-sensitive amine oxidase (SSAO/VAP-1) and monoamine oxidase B (MAO-B). These compounds are useful for treatment of a variety of neuromuscular diseases, such as muscular dystrophies, and neuroinflammatory diseases, including both peripheral and central disorders in human subjects, as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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公开(公告)号：US20210353571A1
公开(公告)日：2021-11-18
申请号：US17265402
申请日：2019-08-02
申请人： Pharmaxis Ltd.
发明人： Alison Dorothy FINDLAY , Craig Ivan TURNER , Mandar DEODHAR , Jonathan Stuart FOOT , Wolfgang JAROLIMEK , Wenbin ZHOU , Alberto BUSON , Angelique Elsa GRECO
IPC分类号： A61K31/18 , A61P17/02 , A61P35/00 , A61P19/04 , A61P35/04 , C07C311/29 , C07C317/32 , C07D213/71 , C07D215/36 , C07D277/64 , C07D209/08 , A61K31/145 , A61K31/4409 , A61K31/47
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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