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公开(公告)号：US20150290328A1
公开(公告)日：2015-10-15
申请号：US14646273
申请日：2013-11-20
IPC分类号： A61K47/42 , A61K38/26 , A61K45/06 , A61K38/22 , A61K47/48 , A61K47/02 , A61K9/00 , A61K47/18 , A61K38/28
CPC分类号： A61K38/2278 , A61K9/0019 , A61K38/00 , A61K38/16 , A61K38/26 , A61K38/28 , A61K45/06 , A61K47/02 , A61K47/183 , A61K47/42 , A61K47/6435
摘要： The present invention provides pharmaceutical formulations for sustained release when administered at cold temperatures, and methods for delivering a treatment regimen with a combination of sustained release and long half-life formulations. The invention provides improved pharmacokinetics for peptide and small molecule drugs.
摘要翻译： 本发明提供了在冷温度下给药时用于持续释放的药物制剂，以及用持续释放和长半衰期制剂组合递送治疗方案的方法。 本发明提供肽和小分子药物的改善的药代动力学。
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公开(公告)号：US11266719B2
公开(公告)日：2022-03-08
申请号：US16907759
申请日：2020-06-22
摘要： The present disclosure provides a method of treating muscle myopathy, including muscle dystrophies and cardiomyopathies, by administering stable, long-lasting vasoactive intestinal peptide therapeutic agents. These agents include one or more clastin-like peptides and can be administered at a low-dose.
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公开(公告)号：US11052132B2
公开(公告)日：2021-07-06
申请号：US15308626
申请日：2015-05-08
发明人： Susan Arnold , David James Ballance
IPC分类号： A61K38/22 , A61K31/404 , A61K31/443 , A61K31/47 , A61K38/39 , A61K45/06
摘要： The present disclosure provides a method of treating diseases or disorders associated with CFTR protein dysfunction, including Cystic Fibrosis, by administering stable, long-lasting vasoactive intestinal peptide therapeutic agents. These agents include one or more elastin-like peptides and can be administered at a low-dose.
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公开(公告)号：US10940182B2
公开(公告)日：2021-03-09
申请号：US15276151
申请日：2016-09-26
IPC分类号： A61K38/22 , C07K14/575 , C07K14/78 , A61K45/06 , A61K31/403 , A61K31/165 , A61K31/4045 , A61K31/4418 , A61K38/39 , A61K38/00
摘要： The present invention is based on the discovery that a VIP having a binding preference for VPAC2 can provide long-acting blood pressure control synergistically with concomitant anti-hypertensive therapies. Accordingly, methods and compositions useful for the treatment and/or amelioration of hypertension are provided.
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公开(公告)号：US10688156B2
公开(公告)日：2020-06-23
申请号：US15546037
申请日：2016-02-09
摘要： The present disclosure provides a method of treating muscle myopathy, including muscle dystrophies and cardiomyopathies, by administering stable, long-lasting vasoactive intestinal peptide therapeutic agents. These agents include one or more elastin-like peptides and can be administered at a low-dose.
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公开(公告)号：US09919032B2
公开(公告)日：2018-03-20
申请号：US15355386
申请日：2016-11-18
CPC分类号： A61K38/2278 , A61K9/0019 , A61K38/00 , A61K38/16 , A61K38/26 , A61K38/28 , A61K45/06 , A61K47/02 , A61K47/183 , A61K47/42 , A61K47/6435
摘要： The present invention provides pharmaceutical formulations for sustained release when administered at cold temperatures, and methods for delivering a treatment regimen with a combination of sustained release and long half-life formulations. The invention provides improved pharmacokinetics for peptide and small molecule drugs.
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公开(公告)号：US20140171370A1
公开(公告)日：2014-06-19
申请号：US14099590
申请日：2013-12-06
发明人： Susan Arnold , Christopher Prior
CPC分类号： A61K38/17 , A61K9/0002 , A61K9/0019 , A61K9/0024 , A61K38/2278 , A61K38/26 , A61K38/39 , A61K47/42
摘要： The present invention provides pharmaceutical formulations for sustained release, and methods for delivering a treatment regimen with a combination of sustained release and long half-life formulations. The invention provides improved pharmacokinetics for peptide and small molecule drugs.
摘要翻译： 本发明提供用于持续释放的药物制剂，以及用持续释放和长半衰期制剂组合递送治疗方案的方法。 本发明提供肽和小分子药物的改善的药代动力学。
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