公开(公告)号：US20230372467A1

公开(公告)日：2023-11-23

申请号：US18320558

申请日：2023-05-19

申请人： Phibro Animal Health Corporation ,  VTT Technical Research Centre of Finland Ltd. ,  Dyadic International (USA), Inc.

发明人： Andriy Kovalchuk ,  Avi Zrachya ,  Avner Finger ,  Noelia Valbuena ,  Ronen Tchelet ,  Markku Saloheimo

IPC分类号： A61K39/17 ,  C12N15/80 ,  C12N1/14

CPC分类号： A61K39/17 ,  C12N15/80 ,  C12N1/145 ,  C12N2800/108 ,  A61K2039/5252

摘要： The present disclosure concerns using transgenic fungus to express recombinant viral antigens. The composition, production, and administration of vaccines comprising those viral antigens also are disclosed. In some embodiments, these viral antigens can be used to formulate a vaccine against Newcastle Disease. These vaccines can be administered, for example, via intramuscular injection.

公开(公告)号：US20220105170A1

公开(公告)日：2022-04-07

申请号：US17554232

申请日：2021-12-17

申请人： Phibro Animal Health Corporation ,  Life Science Research Israel Ltd.

发明人： Avner Finger ,  Avi Zrachya ,  Ofer Cohen ,  Anat Zvi

IPC分类号： A61K39/12 ,  A61K39/39 ,  A61P31/20 ,  C12N7/00

摘要： Peptides predicted to be immunogenic against African swine fever virus (ASFV) and vaccine compositions that include the peptides are disclosed herein. In some embodiments, these compositions comprise or consist of one or more peptides comprising the amino acid sequence set forth in SEQ ID NOs: 2-2273. In other embodiments, the compositions comprise viral vectors or host cells, or combinations thereof, that comprise one or more of the peptides. In other embodiments, the compositions comprise nucleic acid molecules comprising one or more of the peptides. The compositions disclosed can include one or more additional components, such as, but not limited to, a carrier, an adjuvant, an additional therapeutic, or combinations thereof. Containers and kits that comprise the compositions are described. Uses of the compositions can include administration to an animal to induce an immune response in the animal, or to immunize the animal against ASFV. Administration can be accomplished using one or more of various methods as described herein, such as intramuscular or intranasal administration.