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公开(公告)号:US20180371027A1
公开(公告)日:2018-12-27
申请号:US16063007
申请日:2016-12-23
申请人: VALNEVA AUSTRIA GMBH
CPC分类号: A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/5254 , A61K2039/5258 , A61K2039/55505 , A61P31/14 , C07K14/18 , C07K14/1825 , C12N7/00 , C12N7/02 , C12N7/06 , C12N2770/24134 , C12N2770/24151 , C12N2770/24163 , Y02A50/383 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/392
摘要: Described herein are Zika virus vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.
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公开(公告)号:US20180353594A1
公开(公告)日:2018-12-13
申请号:US16107410
申请日:2018-08-21
IPC分类号: A61K39/145 , A61L2/00 , A61K41/00 , A61K39/00
CPC分类号: A61K39/145 , A61K41/0009 , A61K2039/5252 , A61L2/007 , A61L2202/21
摘要: The invention relates to a method for inactivating viruses, characterized in that an immunogenic composition or vaccine comprising at least one virus is irradiated with electron beams, said immunogenic composition or vaccine comprising at least one virus (i) being liquid, in particular being a suspension and (ii) comprising at least one viral immunogen, wherein the antigen structure is preferably substantially retained.
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公开(公告)号:US20180344838A1
公开(公告)日:2018-12-06
申请号:US16009848
申请日:2018-06-15
申请人: ModernaTX, Inc.
发明人: Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tal Zaks , Sunny Himansu
CPC分类号: A61K39/12 , A61K9/0019 , A61K9/14 , A61K9/51 , A61K9/5123 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/28 , A61K2039/505 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/543 , A61K2039/6056 , A61P31/14 , C07K14/005 , C07K16/1081 , C07K16/2851 , C07K2317/33 , C07K2317/76 , C12N7/00 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , Y02A50/383 , Y02A50/386 , Y02A50/39 , Y02A50/392 , Y02A50/51
摘要: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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4.
公开(公告)号:US20180326042A1
公开(公告)日:2018-11-15
申请号:US15777441
申请日:2016-11-28
发明人: Eiji KIYOTOH , Mitsuhiko HORI , Daisuke ASARI , Katsuyuki OKUBO , Takuya SHISHIDO , Masahiro FUKASAKA , Kyohei MATSUSHITA
IPC分类号: A61K39/145 , A61K9/19 , A61K47/18 , A61K47/26
CPC分类号: A61K39/145 , A61K9/19 , A61K39/00 , A61K47/18 , A61K47/183 , A61K47/26 , A61K2039/5252 , A61K2039/55511 , A61P31/16
摘要: The present invention provides a dried influenza vaccine preparation in which the activity of an influenza vaccine can be stably maintained even if the preparation is stored without strict temperature control and which can be stably supplied. The present invention also provides a method for producing the dried influenza vaccine preparation. Provided is a dried influenza vaccine preparation including: an influenza vaccine antigen; a disaccharide; and an-amino acid.
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公开(公告)号:US20180326039A1
公开(公告)日:2018-11-15
申请号:US15760341
申请日:2016-09-16
发明人: Shunji HARUTA
IPC分类号: A61K39/145 , A61K9/19
CPC分类号: A61K39/145 , A61K9/0043 , A61K9/145 , A61K9/146 , A61K9/1682 , A61K9/19 , A61K39/395 , A61K47/36 , A61K47/38 , A61K2039/5252 , A61K2039/543 , A61K2039/55511 , A61K2039/55583 , A61K2039/70 , A61M31/00 , C12N2760/16134
摘要: Provided herein are vaccine compositions for example in a dry powder form for intranasal delivery, and their preparation methods. Also provided are methods of using vaccine compositions, for example in stimulating mucosal or systemic immune responses by delivering the vaccine compositions intranasally.
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公开(公告)号:US20180250382A1
公开(公告)日:2018-09-06
申请号:US15846735
申请日:2016-06-23
申请人: MERIAL INC.
发明人: Yu-Wei Chiang , David Cureton , Herve Poulet
IPC分类号: A61K39/145 , A61P31/16 , G01N33/569
CPC分类号: A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , A61P31/16 , C12N2760/16134 , G01N33/56983
摘要: The present invention relates to canine influenza virus strains, and vaccines and compositions. The present invention also relates to reagents and methods allowing their detection, methods of vaccination as well as methods of producing these reagents and vaccines.
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公开(公告)号:US20180243405A1
公开(公告)日:2018-08-30
申请号:US15966986
申请日:2018-04-30
申请人: STRECK, INC.
发明人: Wayne L. Ryan , James A. Grukemeyer
IPC分类号: A61K39/275 , C12N7/00 , A61K39/12 , A61K39/00
CPC分类号: A61K39/275 , A61K39/12 , A61K2039/5252 , C12N7/00 , C12N2760/16134 , C12N2760/16163
摘要: The present invention is directed at a composition comprising a live swine flu virus having an infectious component and a plurality of surface antigens in contact with a formaldehyde donor agent having a molecular weight that is less than about 400 g/mol. Preferably, the formaldehyde donor agent is selected from a non-crosslinking chemical fixative that contains urea.
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公开(公告)号:US10034931B2
公开(公告)日:2018-07-31
申请号:US15024102
申请日:2014-09-23
申请人: Emory University
IPC分类号: A61K39/145 , A61K45/06 , A61K31/517 , A61K9/00 , C12N7/00 , A61K39/39 , A61K39/00
CPC分类号: A61K39/145 , A61K9/0014 , A61K9/0021 , A61K31/517 , A61K39/39 , A61K45/06 , A61K2039/5252 , A61K2039/54 , A61K2039/55511 , A61K2039/55516 , A61K2039/572 , A61K2039/575 , C12N7/00 , C12N2760/16134 , C12N2760/16163 , C12N2760/16171 , C12N2760/16234 , A61K2300/00
摘要: This disclosure relates to using EGFR pathway inhibitors in combination with compositions comprising an antigen to increase, elicit, or improve an antigen or vaccine-induced immune response. In certain embodiments, the EGFR pathway inhibitor is administered under conditions such that memory cells to the antigen are formed in a subject. In certain embodiments, the composition is a vaccine. In certain embodiments, the EGFR pathway inhibitor and vaccine are administered to the skin epidermis or dermis.
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公开(公告)号:US20180169223A1
公开(公告)日:2018-06-21
申请号:US15597371
申请日:2017-05-17
申请人: Nikolai Petrovsky
发明人: Nikolai Petrovsky
IPC分类号: A61K39/39 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/29 , A61K39/35 , A61K39/395 , A61K31/715 , A61K39/00
CPC分类号: A61K39/39 , A61K31/715 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/292 , A61K39/35 , A61K39/395 , A61K2039/5252 , A61K2039/55511 , A61K2039/55561 , A61K2039/55583 , C12N2730/10134 , C12N2760/16134 , C12N2760/20134
摘要: The present invention provides a pharmaceutically acceptable composition comprising: particles of inulin; a substance comprising or consisting of one or more pathogen-associated molecular patterns (PAMPs), and an antigen for use inducing or modulating an immune response in a subject, such as modulating an immune response to an antigen or allergen and/or as a vaccine.
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公开(公告)号:US20180169215A1
公开(公告)日:2018-06-21
申请号:US15737239
申请日:2016-06-15
申请人: Emory University
发明人: Martin L. Moore , Sujin Lee , Minh Trang Nguyen
IPC分类号: A61K39/125 , A61P31/16
CPC分类号: A61K39/125 , A61K39/12 , A61K2039/5252 , A61K2039/545 , A61K2039/55505 , A61K2039/70 , A61P31/16 , C12N2770/32334
摘要: This disclosure relates to multivalent enterovirus vaccine compositions and uses related thereto. In certain embodiments, the disclosure relates to vaccine compositions comprising multivalent, mixtures of enterovirus (for example HRV) serotypes or recombinantly produced variants or recombinantly produced viral capsid proteins. In certain embodiments, the disclosure relates to methods of immunization comprising administering an effective amount of compositions disclosed herein to a subject diagnosed with, exhibiting symptoms of, or at risk of an enterovirus infection.
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