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1.发明申请INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO 审中-公开HEDGEHOG信号通道，组合物和相关用途的抑制剂公开(公告)号：US20100273818A1
公开(公告)日：2010-10-28
申请号：US12652134
申请日：2010-01-05
IPC分类号： A61K31/438 , A61P35/00 , C12N5/02 , A61P15/16
CPC分类号： A61K31/4355 , A61K31/00 , A61K31/435 , A61K31/438 , A61K31/58
摘要： The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
摘要翻译： 本发明使得可用性测定和试剂抑制由刺猬蛋白质产生的旁分泌和/或自分泌信号或异常激活刺猬蛋白信号转导途径，例如涉及使用甾族生物碱或其它小分子。
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2.发明授权Inhibitors of hedgehog signal pathways, compositions and uses related thereto 有权刺猬信号通路抑制剂，组合物和与之相关的用途公开(公告)号：US06867216B1
公开(公告)日：2005-03-15
申请号：US09708974
申请日：2000-11-08
IPC分类号： A61K31/00 , A61K31/4355 , A61K31/58 , A61K31/44
CPC分类号： A61K31/58 , A61K31/00 , A61K31/4355
摘要： The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
摘要翻译： 本发明使得可用性测定和试剂抑制由刺猬蛋白质产生的旁分泌和/或自分泌信号或异常激活刺猬蛋白信号转导途径，例如涉及使用甾族生物碱或其它小分子。
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公开(公告)号：US08076073B2
公开(公告)日：2011-12-13
申请号：US10442435
申请日：2003-05-20
CPC分类号： A61K31/4355 , Y10S435/962 , Y10T436/141111
摘要： The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
摘要翻译： 本发明固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。 在本发明的一个方面，该方法提供了影响细胞中胆固醇生物合成或转运的方法，包括使细胞与有效量的影响刺猬蛋白的化合物接触，从而影响胆固醇生物合成或转运。 该作用可能是抑制或刺激胆固醇生物合成或运输。
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公开(公告)号：US06432970B1
公开(公告)日：2002-08-13
申请号：US09090622
申请日：1998-06-04
IPC分类号： A61K3144
摘要： The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein comprising contacting a cell sensitive to the hedgehog protein with a steroidal alkaloid, or other small molecule, in a sufficient amount to reduce the sensitivity of the cell to the hedgehog protein.
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5.发明申请INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO 审中-公开HEDGEHOG信号通道，组合物和相关用途的抑制剂公开(公告)号：US20120183603A1
公开(公告)日：2012-07-19
申请号：US13364121
申请日：2012-02-01
IPC分类号： A61K31/4355 , A61P35/00 , A61K9/127
CPC分类号： A61K31/4355 , A61K31/00 , A61K31/435 , A61K31/438 , A61K31/58
摘要： The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
摘要翻译： 本发明使得可用性测定和试剂抑制由刺猬蛋白质产生的旁分泌和/或自分泌信号或异常激活刺猬蛋白信号转导途径，例如涉及使用甾族生物碱或其它小分子。
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6.发明授权Inhibitors of hedgehog signaling pathways, compositions and uses related thereto 有权刺猬蛋白信号通路抑制剂，组合物和与之相关的用途公开(公告)号：US07291626B1
公开(公告)日：2007-11-06
申请号：US09708964
申请日：2000-11-08
IPC分类号： A61K31/4355
CPC分类号： A61K31/4355 , A61K31/00 , A61K31/435 , A61K31/438 , A61K31/58
摘要： The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
摘要翻译： 本发明使得可用性测定和试剂抑制由刺猬蛋白质产生的旁分泌和/或自分泌信号或异常激活刺猬蛋白信号转导途径，例如涉及使用甾族生物碱或其它小分子。
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公开(公告)号：US06288048B1
公开(公告)日：2001-09-11
申请号：US09250785
申请日：1999-02-12
IPC分类号： A61K3158
CPC分类号： A61K31/4355 , Y10S435/962 , Y10T436/141111
摘要： The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
摘要翻译： 本发明固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。 在本发明的一个方面，该方法提供了影响细胞中胆固醇生物合成或转运的方法，包括使细胞与有效量的影响刺猬蛋白的化合物接触，从而影响胆固醇生物合成或转运。 该作用可能是抑制或刺激胆固醇生物合成或运输。
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公开(公告)号：US09427431B2
公开(公告)日：2016-08-30
申请号：US13364121
申请日：2012-02-01
IPC分类号： A61K31/4355 , A61K31/00 , A61K31/435 , A61K31/438 , A61K31/58
CPC分类号： A61K31/4355 , A61K31/00 , A61K31/435 , A61K31/438 , A61K31/58
摘要： The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
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9.发明授权Inhibitors of hedgehog signaling pathways, compositions and uses related thereto 有权刺猬蛋白信号通路抑制剂，组合物和与之相关的用途公开(公告)号：US08097632B2
公开(公告)日：2012-01-17
申请号：US11894712
申请日：2007-08-20
IPC分类号： A61K31/44
CPC分类号： A61K31/4355 , A61K31/00 , A61K31/435 , A61K31/438 , A61K31/58
摘要： The present invention makes available assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
摘要翻译： 本发明提供了抑制由刺猬蛋白产生的旁分泌和/或自分泌信号的测定和试剂，例如涉及使用甾族生物碱或其他小分子的刺猬蛋白信号转导途径的异常活化。
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