公开(公告)号：US20180328950A1

公开(公告)日：2018-11-15

申请号：US15836061

申请日：2017-12-08

申请人： Marshfield Clinic, Inc.

发明人： Michael E.M. Larson ,  Thomas M. Richards

IPC分类号： G01N33/70 ,  G01N33/94

CPC分类号： G01N33/70 ,  G01N33/94 ,  G01N33/946 ,  G01N33/9486 ,  Y10S436/808 ,  Y10S436/901 ,  Y10T436/141111 ,  Y10T436/145555 ,  Y10T436/147777 ,  Y10T436/173845

摘要： The present invention provides methods for detecting and quantifying metabolites in a biological sample by measuring the concentration of a test metabolite in the sample and comparing that concentration against the concentration of the reference metabolite; enabling accurate metabolite concentration measurements to determine aberrant drug usage patterns. Also disclosed is an analytical testing device and related computer-assisted products for detecting and quantifying metabolites in a biological sample efficiently and accurately.

公开(公告)号：US09993491B2

公开(公告)日：2018-06-12

申请号：US14616164

申请日：2015-02-06

申请人： SOCPRA—SCIENCES ET GENIE S.E.C.

发明人： Jerome Mulhbacher ,  Daniel Lafontaine ,  Francois Malouin ,  Marianne Allard ,  Eric Marsault

IPC分类号： A61K31/505 ,  A61K31/513 ,  A61K31/675 ,  A61K31/54 ,  A61K31/535 ,  A61K31/542 ,  A61K31/519 ,  A61K31/5383 ,  A61K31/4412 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D498/04 ,  C07D513/04

CPC分类号： A61K31/675 ,  A61K31/4412 ,  A61K31/505 ,  A61K31/513 ,  A61K31/519 ,  A61K31/535 ,  A61K31/5383 ,  A61K31/54 ,  A61K31/542 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D498/04 ,  C07D513/04 ,  Y10T436/141111 ,  Y10T436/143333

摘要： The present invention includes novel compounds and pharmaceutically acceptable formulations of said compounds which exhibit antibiotic activity against microorganisms bearing a guanine riboswitch that controls the expression of the guaA gene, including organisms which are resistant to certain antibiotic families, and which are useful as antibacterial agents for treatment or prophylaxis of bacterial infections in animals or in humans, in particular but not limited to infections of the mammary gland, or their use as antiseptics, agents for sterilization or disinfection.

公开(公告)号：US20180141938A1

公开(公告)日：2018-05-24

申请号：US15875897

申请日：2018-01-19

申请人： Rigel Pharmaceuticals, Inc.

发明人： Esteban Masuda ,  Rajinder Singh ,  Vanessa Taylor ,  Donald G. Payan

IPC分类号： C07D413/12 ,  A61K31/675 ,  A61K45/06 ,  C07F9/653 ,  A61K31/506

CPC分类号： C07D413/12 ,  A61K31/506 ,  A61K31/675 ,  A61K45/06 ,  C07F9/65324 ,  Y10T436/141111 ,  A61K2300/00

摘要： Compounds and embodiments of a method for treating and/or preventing autoimmune diseases are disclosed. The method includes administering to a subject having an autoimmune disease, such as an inflammatory bowel disease, a therapeutically effective amount of a compound according to formula I wherein X and Y independently are O or NR1; each R1 is independently H or C1-C6 alkyl; ring A is aryl; each R2 independently is H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system; p is 0, 1, 2, 3, or 4; R3 and R4 independently are H or C1-C6 alkyl; and R5 is halo, cyano, or C1-C6 alkyl.

公开(公告)号：US09890144B2

公开(公告)日：2018-02-13

申请号：US14750794

申请日：2015-06-25

申请人： Rigel Pharmaceuticals, Inc.

发明人： Esteban Masuda ,  Rajinder Singh ,  Vanessa Taylor ,  Donald G. Payan

IPC分类号： A61K31/506 ,  A61K31/675 ,  C07D413/12 ,  C07F9/653 ,  A61K45/06

CPC分类号： C07D413/12 ,  A61K31/506 ,  A61K31/675 ,  A61K45/06 ,  C07F9/65324 ,  Y10T436/141111 ,  A61K2300/00

摘要： Compounds and embodiments of a method for treating and/or preventing autoimmune diseases are disclosed. The method includes administering to a subject having an autoimmune disease, such as an inflammatory bowel disease, a therapeutically effective amount of a compound according to formula I wherein X and Y independently are O or NR1; each R1 is independently H or C1-C6 alkyl; ring A is aryl; each R2 independently is H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system; p is 0, 1, 2, 3, or 4; R3 and R4 independently are H or C1-C6 alkyl; and R5 is halo, cyano, or C1-C6 alkyl.

公开(公告)号：US20170299566A1

公开(公告)日：2017-10-19

申请号：US15435733

申请日：2017-02-17

申请人： Massachusetts Institute Of Technology

发明人： Kerin E. Gregory ,  Roderick R. Kunz ,  Michael Sworin

IPC分类号： G01N33/22 ,  G01N27/62 ,  G01N31/22 ,  G01N1/02

CPC分类号： G01N33/227 ,  G01N27/622 ,  G01N31/227 ,  G01N2001/028 ,  Y10T436/141111 ,  Y10T436/143333 ,  Y10T436/173076 ,  Y10T436/19 ,  Y10T436/206664 ,  Y10T436/24

摘要： Reagents and methods are disclosed for detection of oxidizers and inorganic salts and other analytes of interest. The reagents can interact with their target analytes, especially oxidizer compositions or oxidizer-based explosives, to selectively enhance their ionization yield, interacting by chemical reaction or by forming an associative adduct which facilitates their detection. For example, the reagents can adduct with the counter-ion of the intended analyte for improved direct detection and/or react chemically via acid-base reactions to produce a new product for detection. In another aspect of the invention, reactive reagents and methods are also disclosed that facilitate indirect detection of the analyte at lower temperatures based on reduction-oxidation (redox) chemistry. These reagents are particularly useful in detecting oxidizer analytes.

公开(公告)号：US09530928B2

公开(公告)日：2016-12-27

申请号：US14103725

申请日：2013-12-11

申请人： The Regents of the University of California

发明人： Shimon Weiss ,  Marcel Bruchez ,  Paul A. Alivisatos

IPC分类号： G01N33/50 ,  H01L33/00 ,  B82Y15/00 ,  C09K11/02 ,  C09K11/56 ,  C09K11/88 ,  C09K11/89 ,  C12Q1/68 ,  G01N33/533 ,  G01N33/542 ,  G01N33/543 ,  G01N33/58 ,  G01N33/48

CPC分类号： H01L33/0062 ,  B82Y15/00 ,  C09K11/025 ,  C09K11/565 ,  C09K11/883 ,  C09K11/89 ,  C09K11/892 ,  C12Q1/6816 ,  C12Q2563/107 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54373 ,  G01N33/588 ,  H01L33/0083 ,  Y10T436/141111 ,  Y10T436/142222

摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

摘要翻译： 描述了半导体纳米晶体化合物和探针。 该化合物能够连接至一个或多个亲和分子。 化合物包括（1）能够响应于暴露于第一能量提供第二能量的一种或多种半导体纳米晶体，和（2）一种或多种连接剂，其具有连接到所述一种或多种半导体纳米晶体的第一部分 和能够连接到一个或多个亲和分子的第二部分。 一个或多个半导体纳米晶体化合物与一个或多个亲和分子连接以形成半导体纳米晶体探针，该半导体纳米晶体探针能够与正在分析的材料中的一种或多种可检测物质结合，并且能够响应于暴露于第一能量而提供 第二节能量。 还描述了分别制造半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并用探针处理材料。

公开(公告)号：US20150313899A1

公开(公告)日：2015-11-05

申请号：US14750794

申请日：2015-06-25

申请人： Rigel Pharmaceuticals, Inc.

发明人： Esteban Masuda ,  Rajinder Singh ,  Vanessa Taylor ,  Donald G. Payan

IPC分类号： A61K31/506 ,  A61K31/675

CPC分类号： C07D413/12 ,  A61K31/506 ,  A61K31/675 ,  A61K45/06 ,  C07F9/65324 ,  Y10T436/141111 ,  A61K2300/00

摘要： Compounds and embodiments of a method for treating and/or preventing autoimmune diseases are disclosed. The method includes administering to a subject having an autoimmune disease, such as an inflammatory bowel disease, a therapeutically effective amount of a compound according to formula I wherein X and Y independently are O or NR1; each R1 is independently H or C1-C6 alkyl; ring A is aryl; each R2 independently is H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system; p is 0, 1, 2, 3, or 4; R3 and R4 independently are H or C1-C6 alkyl; and R5 is halo, cyano, or C1-C6 alkyl.

摘要翻译： 公开了用于治疗和/或预防自身免疫疾病的方法的化合物和实施方案。 该方法包括向具有自身免疫性疾病如炎症性肠病的受试者施用治疗有效量的式I化合物，其中X和Y独立地为O或NR 1; 每个R 1独立地为H或C 1 -C 6烷基; 环A是芳基; 每个R 2独立地是与它们所连接的原子或原子一起形成的H，烷基，烷氧基，酰胺，氰基，卤素，卤代烷基，羟基烷基，杂烷基，杂环基，磺酰基，磺酰胺或两个R 2基团 4-10元环系; p为0,1,2,3或4; R3和R4独立地是H或C1-C6烷基; 且R 5为卤素，氰基或C 1 -C 6烷基。

公开(公告)号：US20150247863A1

公开(公告)日：2015-09-03

申请号：US14709886

申请日：2015-05-12

申请人： LIFE TECHNOLOGIES CORPORATION

发明人： Zhenjun DIWU ,  Jixiang LIU ,  Kyle GEE

IPC分类号： G01N33/58 ,  C07D491/147 ,  C12Q1/68 ,  C07D498/14 ,  C07D495/14 ,  C07D495/22 ,  C07D491/22

CPC分类号： G01N33/582 ,  C07D471/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/14 ,  C07D491/147 ,  C07D491/22 ,  C07D495/04 ,  C07D495/14 ,  C07D495/22 ,  C07D498/14 ,  C12Q1/6816 ,  Y10S436/80 ,  Y10T436/141111 ,  Y10T436/143333 ,  Y10T436/145555 ,  C12Q2563/107

摘要： The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.

摘要翻译： 本发明描述了新颖的染料，包括掺入另外的稠合芳环的香豆素，罗丹明和罗丹醇。 本发明的染料比不具有稠合芳环的结构相似的染料长的波长吸收。 本发明的许多染料是有用的荧光染料。 本发明包括化学活性染料，染料共轭物，以及这些染料在染色样品和检测配体或其他分析物中的用途。

公开(公告)号：US20150132746A1

公开(公告)日：2015-05-14

申请号：US14402810

申请日：2013-05-29

申请人： UNIVERSITY OF OSLO

发明人： Astrid Gjelstad ,  Lars Erik Eng Eibak ,  Anne Bee Hegge ,  Knut Einar Rasmussen ,  Stig Pedersen-Bjergaard

IPC分类号： G01N1/36 ,  G01N33/94

CPC分类号： G01N1/36 ,  A61B5/15 ,  A61B5/150358 ,  G01N33/52 ,  G01N33/946 ,  G01N33/9486 ,  G01N2001/364 ,  Y10T436/141111 ,  Y10T436/143333 ,  Y10T436/173845 ,  Y10T436/174614 ,  Y10T436/25

摘要： Provided herein is technology relating to the collection of biological samples and particularly, but not exclusively, to compositions, methods, and uses related to using a biopolymer substrate to collect biological samples for analysis.

摘要翻译： 本文提供了与收集生物样品有关的技术，特别是但不排他地涉及与使用生物聚合物底物收集用于分析的生物样品相关的组合物，方法和用途。

公开(公告)号：US20150064212A1

公开(公告)日：2015-03-05

申请号：US14535007

申请日：2014-11-06

申请人： Instituto Nacional De Psiquiatria Ramon De La Fuente Muniz

发明人： Benito Anton PALMA ,  Philippe Leff GELMAN

IPC分类号： A61K47/48 ,  C07K16/44 ,  C07K16/12 ,  A61K39/08 ,  A61K39/00 ,  A61K39/39

CPC分类号： C07K16/1282 ,  A61K39/0013 ,  A61K39/08 ,  A61K39/385 ,  A61K39/39 ,  A61K47/542 ,  A61K47/6415 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/70 ,  C07K16/44 ,  C07K2317/20 ,  C07K2317/76 ,  Y10T436/141111

摘要： Provided are bivalent immunogenic composition against morphine-heroin addiction comprising a carrier protein (“CP”) and a morphinic product, wherein the CP and the morphinic product are connected by a spacer-linker arm having a total molecular size of 16-21 Å, and methods of using the same.

摘要翻译： 提供了针对吗啡 - 海洛因成瘾的二价免疫原性组合物，其包含载体蛋白（“CP”）和吗啡产物，其中CP和吗啡产物通过总分子量为16-21的间隔基 - 连接臂连接， 及其使用方法。