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公开(公告)号：US08163763B2
公开(公告)日：2012-04-24
申请号：US12533935
申请日：2009-07-31
申请人： Philippe Bergeron , Frederick Cohen , Anthony Estrada , Michael F. T. Koehler , Kevin Hon Luen Lau , Cuong Ly , Joseph P. Lyssikatos , Daniel Ortwine , Zhonghua Pei , Xianrui Zhao
发明人： Philippe Bergeron , Frederick Cohen , Anthony Estrada , Michael F. T. Koehler , Kevin Hon Luen Lau , Cuong Ly , Joseph P. Lyssikatos , Daniel Ortwine , Zhonghua Pei , Xianrui Zhao
IPC分类号： A61K31/519 , C07D471/04
CPC分类号： C07D471/18 , C07D471/14
摘要： Disclosed are compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).
摘要翻译： 公开了式I化合物，其包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐，其可用于调节PIKK相关激酶信号传导，例如mTOR和用于治疗疾病（例如癌症）， 至少部分地由PIKK信号通路的失调（例如mTOR）介导。
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公开(公告)号：US20100069357A1
公开(公告)日：2010-03-18
申请号：US12533935
申请日：2009-07-31
申请人： Philippe Bergeron , Frederick Cohen , Anthony Estrada , Michael F.T. Koehler , Kevin Hon Luen Lau , Cuong Ly , Joseph P. Lyssikatos , Daniel Ortwine , Zhonghua Pei , Xianrui Zhao
发明人： Philippe Bergeron , Frederick Cohen , Anthony Estrada , Michael F.T. Koehler , Kevin Hon Luen Lau , Cuong Ly , Joseph P. Lyssikatos , Daniel Ortwine , Zhonghua Pei , Xianrui Zhao
IPC分类号： A61K31/5377 , C07D487/04 , C07D471/04 , A61K31/55 , A61K31/553 , A61K31/519 , A61P35/00
CPC分类号： C07D471/18 , C07D471/14
摘要： Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).
摘要翻译： 公开了式I化合物，包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐，其可用于调节PIKK相关激酶信号传导，例如mTOR，以及用于治疗疾病（例如癌症） 至少部分地由PIKK信号通路的失调（例如mTOR）介导。
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公开(公告)号：US20120165313A1
公开(公告)日：2012-06-28
申请号：US13410246
申请日：2012-03-01
申请人： Philippe Bergeron , Frederick Cohen , Anthony Estrada , Michael F.T. Koehler , Kevin Hon Luen Lau , Coung Ly , Joseph P. Lyssikatos , Daniel Ortwine , Zhonghua Pei , Xianrui Zhao
发明人： Philippe Bergeron , Frederick Cohen , Anthony Estrada , Michael F.T. Koehler , Kevin Hon Luen Lau , Coung Ly , Joseph P. Lyssikatos , Daniel Ortwine , Zhonghua Pei , Xianrui Zhao
IPC分类号： A61K31/553 , A61K31/5377 , C07D491/048 , A61K31/519 , C07D471/04 , A61P35/02 , A61K31/55 , C07D471/14 , C07D491/08 , C07D471/18 , A61P35/00 , C07D487/04 , A61K31/5386
CPC分类号： C07D471/18 , C07D471/14
摘要： Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).
摘要翻译： 公开了式I化合物，包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐，其可用于调节PIKK相关激酶信号传导，例如mTOR，以及用于治疗疾病（例如癌症） 至少部分地由PIKK信号通路的失调（例如mTOR）介导。
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公开(公告)号：US20110086841A1
公开(公告)日：2011-04-14
申请号：US12943284
申请日：2010-11-10
IPC分类号： A61K31/5377 , C07D473/40 , A61P35/00 , A61P35/02
CPC分类号： A61K31/52 , A61K31/5377 , C07D473/34
摘要： The present invention relates to compounds of Formula I: wherein R1, R2, R3, A1, A2, A3, A4 and D have the meaning described herein. The present invention also relates to pharmaceutical compositions comprising such compounds and therapeutic uses thereof.
摘要翻译： 本发明涉及式I化合物：其中R1，R2，R3，A1，A2，A3，A4和D具有本文所述的含义。 本发明还涉及包含这些化合物的药物组合物及其治疗用途。
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公开(公告)号：US08288381B2
公开(公告)日：2012-10-16
申请号：US12943284
申请日：2010-11-10
IPC分类号： A61K31/52 , A61P35/00 , C07D473/34 , C07D473/40
CPC分类号： A61K31/52 , A61K31/5377 , C07D473/34
摘要： The present invention relates to compounds of Formula I: wherein R1, R2, R3, A1, A2, A3, A4 and D have the meaning described herein. The present invention also relates to pharmaceutical compositions comprising such compounds and therapeutic uses thereof.
摘要翻译： 本发明涉及式I化合物：其中R1，R2，R3，A1，A2，A3，A4和D具有本文所述的含义。 本发明还涉及包含这些化合物的药物组合物及其治疗用途。
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