公开(公告)号：US20070265224A1

公开(公告)日：2007-11-15

申请号：US11818666

申请日：2007-06-14

申请人： Phillip Cook ,  Guangyi Wang ,  Thomas Bruice ,  Nicholas Boyle ,  Janet Leeds ,  Jennifer Brooks ,  Marija Prhavc ,  Maria Ariza ,  Patrick Fagan ,  Yi Jin ,  Vivek Rajwanshi ,  Kathleen Tucker

发明人： Phillip Cook ,  Guangyi Wang ,  Thomas Bruice ,  Nicholas Boyle ,  Janet Leeds ,  Jennifer Brooks ,  Marija Prhavc ,  Maria Ariza ,  Patrick Fagan ,  Yi Jin ,  Vivek Rajwanshi ,  Kathleen Tucker

IPC分类号： A61K31/7072 ,  A61K31/505 ,  A61K31/7076 ,  A61P31/12 ,  A61P35/00 ,  C07H19/06 ,  C07H19/16 ,  C07D239/02 ,  A61P31/18 ,  A61P31/00 ,  A61K31/7068

CPC分类号： C07H19/04 ,  C07H19/10 ,  C07H19/14 ,  C07H19/20

摘要： The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.

摘要翻译： 本发明涉及核苷二磷酸模拟物和核苷三磷酸模拟物，其含有二磷酸酯或三磷酸酯部分模拟物和任选的糖修饰和/或碱基修饰。 本发明的核苷酸模拟物以药学上可接受的盐，药学上可接受的前药或药物制剂的形式可用作抗病毒，抗微生物剂和抗癌剂。 本发明提供了一种治疗病毒感染，微生物感染和增殖性疾病的方法。 本发明还涉及包含任选与其它药物活性剂组合的本发明化合物的药物组合物。

公开(公告)号：US20070259832A1

公开(公告)日：2007-11-08

申请号：US11818990

申请日：2007-06-14

申请人： Phillip Cook ,  Guangyi Wang ,  Thomas Bruice ,  Nicholas Boyle ,  Janet Leeds ,  Jennifer Brooks ,  Marija Prhavc ,  Maria Ariza ,  Patrick Fagan ,  Yi Jin ,  Vivek Rajwanshi ,  Kathleen Tucker

发明人： Phillip Cook ,  Guangyi Wang ,  Thomas Bruice ,  Nicholas Boyle ,  Janet Leeds ,  Jennifer Brooks ,  Marija Prhavc ,  Maria Ariza ,  Patrick Fagan ,  Yi Jin ,  Vivek Rajwanshi ,  Kathleen Tucker

IPC分类号： A61K31/711 ,  C07H19/04

CPC分类号： C07H19/04 ,  C07H19/10 ,  C07H19/14 ,  C07H19/20

摘要： The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.