公开(公告)号：US20120219574A1

公开(公告)日：2012-08-30

申请号：US13443536

申请日：2012-04-10

申请人： Phillip FROST ,  Thomas Kodadek

发明人： Phillip FROST ,  Thomas Kodadek

IPC分类号： A61K39/00 ,  G01N33/566 ,  C07K7/64 ,  A61P37/04 ,  A61K38/12 ,  A61P17/00 ,  A61K35/14 ,  C40B20/00 ,  C12N5/0783

CPC分类号： C07K7/54 ,  A61K39/0008 ,  G01N33/564 ,  G01N2500/04 ,  G01N2500/10 ,  Y02A50/414

摘要： The present invention provides for the identification of an antigen surrogate to the native antigens for the autoimmune disease pemphigus vulgaris. Ligands are discovered using large random peptoid or cyclic peptoid libraries that are screened against known antibodies to autoimmune diseases. The ligands may be useful as drugs in the treatment of such diseases and can also be used in combination with the concomitant removal of T-cells associated with autoimmune disorders.

摘要翻译： 本发明提供了针对自身免疫病寻常型天疱疮的天然抗原的抗原替代物的鉴定。 使用大量随机拟肽或环状拟肽文库发现配体，其针对自身免疫性疾病的已知抗体进行筛选。 配体可用作治疗这些疾病的药物，并且还可以与伴随自身免疫疾病相关的T细胞的伴随移除使用。

公开(公告)号：US20180153872A1

公开(公告)日：2018-06-07

申请号：US15736950

申请日：2016-07-12

申请人： Phillip FROST ,  OPKO Health, Inc.

发明人： Jane H. HSIAO ,  Phillip FROST

IPC分类号： A61K31/454 ,  A61P17/04

CPC分类号： A61K31/454 ,  A61K31/45 ,  A61P17/04

摘要： The invention relates to pharmaceutical compositions and dosage forms having a piperidine carbonitrile as an active ingredient for the treatment of various diseases and conditions. The preferred compound is a crystalline form of a trifluoromethylphenylalkoxyalkylheteroarylaryl piperidine carbonitrile. Methods of treating diseases and conditions are disclosed as well as processes to make crystalline forms of the above compounds.