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公开(公告)号：US20120219574A1
公开(公告)日：2012-08-30
申请号：US13443536
申请日：2012-04-10
申请人： Phillip FROST , Thomas Kodadek
发明人： Phillip FROST , Thomas Kodadek
IPC分类号： A61K39/00 , G01N33/566 , C07K7/64 , A61P37/04 , A61K38/12 , A61P17/00 , A61K35/14 , C40B20/00 , C12N5/0783
CPC分类号： C07K7/54 , A61K39/0008 , G01N33/564 , G01N2500/04 , G01N2500/10 , Y02A50/414
摘要： The present invention provides for the identification of an antigen surrogate to the native antigens for the autoimmune disease pemphigus vulgaris. Ligands are discovered using large random peptoid or cyclic peptoid libraries that are screened against known antibodies to autoimmune diseases. The ligands may be useful as drugs in the treatment of such diseases and can also be used in combination with the concomitant removal of T-cells associated with autoimmune disorders.
摘要翻译： 本发明提供了针对自身免疫病寻常型天疱疮的天然抗原的抗原替代物的鉴定。 使用大量随机拟肽或环状拟肽文库发现配体，其针对自身免疫性疾病的已知抗体进行筛选。 配体可用作治疗这些疾病的药物，并且还可以与伴随自身免疫疾病相关的T细胞的伴随移除使用。
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公开(公告)号：US08603756B2
公开(公告)日：2013-12-10
申请号：US13443536
申请日：2012-04-10
申请人： Phillip Frost , Thomas Kodadek
发明人： Phillip Frost , Thomas Kodadek
IPC分类号： G01N33/53
CPC分类号： C07K7/54 , A61K39/0008 , G01N33/564 , G01N2500/04 , G01N2500/10 , Y02A50/414
摘要： The present invention provides for the identification of an antigen surrogate to the native antigens for the autoimmune disease pemphigus vulgaris. Ligands are discovered using large random peptoid or cyclic peptoid libraries that are screened against known antibodies to autoimmune diseases. The ligands may be useful as drugs in the treatment of such diseases and can also be used in combination with the concomitant removal of T-cells associated with autoimmune disorders.
摘要翻译： 本发明提供了针对自身免疫病寻常型天疱疮的天然抗原的抗原替代物的鉴定。 使用大量随机拟肽或环状拟肽文库发现配体，其针对自身免疫性疾病的已知抗体进行筛选。 配体可用作治疗这些疾病的药物，并且还可以与伴随自身免疫疾病相关的T细胞的伴随移除使用。
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公开(公告)号：US08334239B2
公开(公告)日：2012-12-18
申请号：US12166042
申请日：2008-07-01
IPC分类号： C40B30/04
CPC分类号： A61K47/481 , A61K38/08 , A61K45/06 , A61K47/55 , A61K49/0043 , A61K2300/00
摘要： A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function.
摘要翻译： 据报道，基于细胞的筛选可以鉴定出显示在珠粒上的拟肽（N-烷基甘氨酸寡聚物）的组合文库中的特异性受体结合化合物。 该策略被应用于分离血管内皮生长因子受体2（VEGFR2）结合的拟肽，其被优化以产生对VEGFR2具有高亲和力的铅化合物。 这些拟肽中的一种被证明是VEGF-VEGFR2相互作用和受体功能的拮抗剂。
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公开(公告)号：US09963481B2
公开(公告)日：2018-05-08
申请号：US14343426
申请日：2012-09-07
IPC分类号： C07K5/08 , A61K31/19 , A61K45/06 , C07D405/14 , C07D405/10 , C07B53/00 , C07C57/52 , C07C57/60 , C07C57/64 , A61K31/192 , A61K38/06 , C07C51/00 , C07K5/02 , C07K5/083 , G01N33/50 , C07C57/54
CPC分类号： C07K5/08 , A61K31/19 , A61K31/192 , A61K38/06 , A61K45/06 , C07B53/00 , C07B2200/07 , C07B2200/11 , C07C51/00 , C07C57/52 , C07C57/54 , C07C57/60 , C07C57/64 , C07D405/10 , C07D405/14 , C07K5/0205 , C07K5/0804 , G01N33/5008 , G01N2800/7028
摘要： Chiral oligomeric pentenoate amides are bio-oligomer mimetics possessing a high degree of conformation rigidity. Conformational rigidity is desirable in the design of molecules with high affinities for biological receptors and enzymes. Libraries of such oligomeric mimetics, such as of chiral oligomeric pentenoate amides can be used to probe biological systems. The present invention provides a method for preparation of chiral oligomeric pentanoate amides comprising conversion of a chiral oxazolidinone (4) to a chiral monomer of formula (1) which can be oligomerized to a chiral compound of formula (12) and so forth.
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公开(公告)号：US20110077201A1
公开(公告)日：2011-03-31
申请号：US12950425
申请日：2010-11-19
CPC分类号： A61K47/481 , A61K38/08 , A61K45/06 , A61K47/55 , A61K49/0043 , A61K2300/00
摘要： A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function.
摘要翻译： 据报道，基于细胞的筛选可以鉴定出显示在珠粒上的拟肽（N-烷基甘氨酸寡聚物）的组合文库中的特异性受体结合化合物。 该策略被应用于分离血管内皮生长因子受体2（VEGFR2）结合的拟肽，其被优化以产生对VEGFR2具有高亲和力的铅化合物。 这些拟肽中的一种被证明是VEGF-VEGFR2相互作用和受体功能的拮抗剂。
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公开(公告)号：US20070003954A1
公开(公告)日：2007-01-04
申请号：US11433069
申请日：2006-05-12
申请人： Thomas Kodadek
发明人： Thomas Kodadek
CPC分类号： G01N33/6854 , G01N33/54366 , G01N33/6803 , G01N33/6842 , G01N33/6845
摘要： Aspects of the present invention describe methodology by which arrays of synthetic molecules can be created and employed for various types of proteomics profiling experiments. The most important of these from a clinical standpoint are the visualization of antibody and T cell binding patterns, which could be employed as a tool for monitoring the state of the immune system of a patient. This may be a generally useful tool for the diagnosis of many types of disease states. Similar techniques are employed to detect the post-translational modification of specific proteins, a tool for the visualization of induction of signal transduction pathways in cells and tissues treated with drugs. Finally, aspects of the invention teache a method for the creation of simpler arrays with less than 100 features that are, nonetheless, effective for protein profiling experiments.
摘要翻译： 本发明的方面描述了可以产生合成分子阵列并用于各种类型的蛋白质组学分析实验的方法。 从临床观点来看，其中最重要的是抗体和T细胞结合模式的可视化，其可以用作监测患者免疫系统状态的工具。 这可能是诊断许多类型疾病状态的一般有用的工具。 采用相似的技术来检测特异性蛋白质的翻译后修饰，用于在用药物治疗的细胞和组织中信号转导途径诱导的可视化工具。 最后，本发明的方面教导了创建具有小于100个特征的更简单阵列的方法，然而对蛋白质分析实验是有效的。
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7.发明授权Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases 有权鉴定由具有神经变性疾病的受试者中的抗体识别的小分子公开(公告)号：US09551721B2
公开(公告)日：2017-01-24
申请号：US12791389
申请日：2010-06-01
申请人： Muralidhar Reddy Moola , Dwight German , Steven Connell , Rosemary Wilson , Johnnie Wilson , Thomas Kodadek
发明人： Muralidhar Reddy Moola , Dwight German , Steven Connell , Rosemary Wilson , Johnnie Wilson , Thomas Kodadek
IPC分类号： A61K39/395 , C07K16/44 , C07C237/20 , C07D317/58 , A61P25/28 , G01N33/53 , C40B30/04 , G01N33/68 , G01N33/564
CPC分类号： G01N33/6896 , G01N33/564 , G01N33/6845 , G01N2800/2821 , G01N2800/2835
摘要： The present invention provides for the identification of individuals having neurodegenerative diseases (ND). Peptoids recognized by Parkinson's Disease- and Alzheimer's Disease-specific antibodies are identified, allowing one to diagnose or predict ND in subjects.
摘要翻译： 本发明提供了具有神经变性疾病（ND）的个体的鉴定。 鉴定出帕金森氏病和阿尔茨海默氏病特异性抗体识别的Peptoid，可以诊断或预测受试者的ND。
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公开(公告)号：US20100256006A1
公开(公告)日：2010-10-07
申请号：US12722992
申请日：2010-03-12
申请人： Thomas Kodadek
发明人： Thomas Kodadek
CPC分类号： G01N33/54386
摘要： The present invention relates to methods and compositions for detecting a substance using mixed or multiple element capture agents (MECA). The affinity of a MECA for a target is produced by the concomitant binding of at least two low to moderate affinity capture agents providing a high affinity interaction with a capture target.
摘要翻译： 本发明涉及使用混合或多元素捕获剂（MECA）检测物质的方法和组合物。 通过与捕获靶标提供高亲和力相互作用的至少两种低至中度亲和力捕获剂的伴随结合，产生MECA对靶标的亲和力。
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公开(公告)号：US20060275823A1
公开(公告)日：2006-12-07
申请号：US11391705
申请日：2006-03-28
申请人： Thomas Kodadek
发明人： Thomas Kodadek
CPC分类号： C40B30/04 , C12Q1/6897 , G01N33/6842 , G01N33/6845
摘要： The present invention provides a highly sensitive screening assay for the identification of peptide binding partners to virtually any peptide or polypeptide ligand. Utilizing an expression-repression readout system, the inventors have screened libraries of peptides and identified relatively small peptide molecules that bind to the provided target.
摘要翻译： 本发明提供用于鉴定肽结合配偶体以实际上任何肽或多肽配体的高度灵敏的筛选测定。 利用表达抑制读出系统，本发明人已经筛选了肽的文库并鉴定了与所提供的靶结合的相对小的肽分子。
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公开(公告)号：US20110092384A1
公开(公告)日：2011-04-21
申请号：US12905605
申请日：2010-10-15
申请人： Yong-Uk Kwon , Thomas Kodadek
发明人： Yong-Uk Kwon , Thomas Kodadek
摘要： Embodiments of the invention are directed to a one-bead-two-compound method for the creation of encoded cyclic peptoid libraries. This scheme is useful for the creation of cyclic peptoid microarrays since only the cyclic peptoid, not the linear encoding molecule, contains an attachment residue and thus can be spotted onto an activated substrate.
摘要翻译： 本发明的实施方案涉及用于产生编码的环状拟肽文库的单珠二化合物方法。 该方案对于产生环状拟肽微阵列是有用的，因为只有环状拟肽而不是线性编码分子含有连接残基，因此可以点到活化的底物上。
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