公开(公告)号：US4427659A

公开(公告)日：1984-01-24

申请号：US337503

申请日：1982-01-06

申请人： Pierre Le Francier ,  Francoise Audibert ,  Jean Choay ,  Louis Chedid ,  Edgar Lederer

发明人： Pierre Le Francier ,  Francoise Audibert ,  Jean Choay ,  Louis Chedid ,  Edgar Lederer

IPC分类号： A61K38/00 ,  A61K39/39 ,  A61P37/04 ,  C07K9/00 ,  A61K37/00 ,  C07C103/52

CPC分类号： C07K9/005

摘要： The invention relates to novel compounds of the muramyl-peptide type and to their uses. The muramyl-peptides according to the invention comprise at least two aminoacyl residues in the peptide chain, the second of these aminoacyl residues being D-glutamyl, and they are characterized in that the nitrogen of the first amino-acyl, and forming part of the pepetide linkage connecting the muramyl group to the peptide residue, is substituted by an alkyl group. These compounds are useful notably for the preparation of pharmaceutical compositions, in particular by reason of their regulatory properties on the immune responses of the organism.

摘要翻译： 本发明涉及胞壁酰肽类型的新化合物及其用途。 根据本发明的胞壁酰肽多肽在肽链中包含至少两个氨酰基残基，其中第二个氨酰基残基是D-谷氨酰基，其特征在于第一氨基酰基的氮，并形成 连接胞壁酰胺基与肽残基的肽键连接被烷基取代。 这些化合物特别用于制备药物组合物，特别是由于其对生物体的免疫应答的调节性质。