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公开(公告)号：US5948802A
公开(公告)日：1999-09-07
申请号：US232874
申请日：1999-01-15
申请人： Piyasena Hewawasam , Xi Chen , Min Ding , John E. Starrett, Jr.
发明人： Piyasena Hewawasam , Xi Chen , Min Ding , John E. Starrett, Jr.
IPC分类号： C07D271/10 , A61K31/41 , A61K31/4245 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P1/06 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/02 , A61P15/00 , A61P15/10 , A61P25/00 , A61P25/06 , A61P25/08 , A61P43/00 , C07D271/06 , C07D271/07 , C07D271/113
CPC分类号： C07D271/07
摘要： The present invention provides novel benzoate derivatives having the general formula ##STR1## wherein R is as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of potassium channels.
摘要翻译： 本发明提供具有通式的新颖苯甲酸酯衍生物，其中R如本文所定义，或其无毒的药学上可接受的盐或溶剂化物，并且可用于治疗对钾通道开放有响应的病症。
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公开(公告)号：US07169803B2
公开(公告)日：2007-01-30
申请号：US11074288
申请日：2005-03-07
IPC分类号： A61K31/405 , C07D209/34
CPC分类号： C07D209/34 , C07D403/12
摘要： The present invention provides novel N-substituted fluorooxindoles having the general Formula I wherein the wavy bond represents the racemate, the (R)-enantiomer or the (S)-enantiomer and m, n, p, q, A, B, D, Q, X, and Z are as defined below, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of potassium channels.
摘要翻译： 本发明提供具有通式I的新型N-取代的氟代吲哚，其中波状键表示外消旋物，（R） - 对映体或（S） - 对映体，m，n，p，q，A，B，D， Q，X和Z如下所定义，或其无毒的药学上可接受的盐或溶剂化物，并且可用于治疗对钾通道开放有响应的病症。
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公开(公告)号：US6034113A
公开(公告)日：2000-03-07
申请号：US232033
申请日：1999-01-15
IPC分类号： C07D271/10 , A61K31/4245 , A61P1/00 , A61P9/00 , A61P11/06 , A61P13/00 , A61P15/10 , A61P25/06 , A61P25/08 , A61P43/00 , C07D271/113 , A61K31/41
CPC分类号： C07D271/113
摘要： The present invention provides novel oxadiazolone derivatives having the general formula ##STR1## wherein A, B, D and R are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of the large conductance calcium-activated potassium channels.
摘要翻译： 本发明提供了具有以下通式的新的恶二唑酮衍生物，其中A，B，D和R如本文所定义，或其无毒的药学上可接受的盐或溶剂化物，并且可用于治疗对大开口起反应的病症 电导钙激活钾通道。
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公开(公告)号：US20090162318A1
公开(公告)日：2009-06-25
申请号：US12392620
申请日：2009-02-25
IPC分类号： A61K38/20 , A61K31/55 , A61K31/397 , A61P31/12 , A61K38/21
CPC分类号： C07D487/08 , A61K31/55 , A61K45/06 , C07D471/08 , C07D487/04 , C07D519/00
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I化合物以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US07547690B2
公开(公告)日：2009-06-16
申请号：US12039239
申请日：2008-02-28
申请人： Robert G. Gentles , Xiaofan Zheng , Min Ding , Yong Tu , Ying Han , Piyasena Hewawasam , John F. Kadow , John A. Bender , Kap-Sun Yeung , Katharine A. Grant-Young , Thomas W. Hudyma
发明人： Robert G. Gentles , Xiaofan Zheng , Min Ding , Yong Tu , Ying Han , Piyasena Hewawasam , John F. Kadow , John A. Bender , Kap-Sun Yeung , Katharine A. Grant-Young , Thomas W. Hudyma
IPC分类号： A61P31/00 , A61K31/55 , C07D223/14
CPC分类号： C07D519/00 , C07D487/04
摘要： The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I化合物，包括药学上可接受的盐，以及使用这些化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US07456166B2
公开(公告)日：2008-11-25
申请号：US11743921
申请日：2007-05-03
CPC分类号： C07D519/00
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I化合物以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US20070270406A1
公开(公告)日：2007-11-22
申请号：US11745090
申请日：2007-05-07
申请人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
发明人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
IPC分类号： A61K31/55 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I化合物以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US07153848B2
公开(公告)日：2006-12-26
申请号：US11181639
申请日：2005-07-14
申请人： Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
发明人： Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/425 , A61K31/427 , A61K31/4178 , A61K31/4184 , A61K31/4025 , A61K31/403 , C07D233/32 , C07D413/14 , C07D409/14
CPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D513/14
摘要： Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.
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公开(公告)号：US07399758B2
公开(公告)日：2008-07-15
申请号：US11507731
申请日：2006-08-22
申请人： Nicholas A. Meanwell , Robert G. Gentles , Min Ding , John A. Bender , John F. Kadow , Piyasena Hewawasam , Thomas W. Hudyma , Xiaofan Zheng
发明人： Nicholas A. Meanwell , Robert G. Gentles , Min Ding , John A. Bender , John F. Kadow , Piyasena Hewawasam , Thomas W. Hudyma , Xiaofan Zheng
IPC分类号： A61P31/00 , A61K31/55 , C07D223/14
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US20070275930A1
公开(公告)日：2007-11-29
申请号：US11752354
申请日：2007-05-23
申请人： Robert G. Gentles , Min Ding , Piyasena Hewawasam
发明人： Robert G. Gentles , Min Ding , Piyasena Hewawasam
IPC分类号： A61K31/55 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
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