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公开(公告)号：US10472380B2
公开(公告)日：2019-11-12
申请号：US15685440
申请日：2017-08-24
IPC分类号： C07F15/00 , A61K31/555 , A61K9/00 , A61K9/51
摘要： The present disclosure relates to novel platinum compositions having a heterocycle ligand and nanoparticles and methods using such compositions, e.g. for treating cancer.
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公开(公告)号：US20190218241A1
公开(公告)日：2019-07-18
申请号：US16364400
申请日：2019-03-26
发明人： Mark T. Bilodeau , Benoît Moreau
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one polar moiety as a ligand.
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公开(公告)号：US09771387B2
公开(公告)日：2017-09-26
申请号：US14905537
申请日：2014-07-16
IPC分类号： A61K31/555 , C07F15/00 , A61K9/00 , A61K9/51
CPC分类号： C07F15/0093 , A61K9/0019 , A61K9/5146 , A61K9/5153 , A61K31/555
摘要： The present disclosure relates to novel platinum compositions having a heterocycle ligand and nanoparticles and methods using such compositions, e.g. for treating cancer.
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公开(公告)号：US20160317549A1
公开(公告)日：2016-11-03
申请号：US15179701
申请日：2016-06-10
IPC分类号： A61K31/555
CPC分类号： A61K31/555 , A61K31/282 , A61K33/24 , C07F15/00
摘要： The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein, engineered protein, antibody, antibody fragment, peptide, agonist, antagonist, aptamer or ligand which may be capable of recognizing a selected target cell population, and/or derivatives/analogs/mimics thereof.
摘要翻译： 本教导涉及用于治疗癌症的化合物和组合物。 在一些实施方案中，组合物包含具有至少一个反应基团的铂（IV）络合物，所述反应基团可与蛋白质，工程改造的蛋白质，抗体，抗体片段，肽，激动剂，拮抗剂，适体或配体的官能团反应， 识别所选择的靶细胞群体和/或其衍生物/类似物/模拟物。
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公开(公告)号：US10342801B2
公开(公告)日：2019-07-09
申请号：US15737064
申请日：2016-06-22
发明人： Rossitza G. Alargova , Mark T. Bilodeau , Richard Wooster , Benoît Moreau , Kerry Whalen , J. Michael Ramstack , Danielle N. Rockwood , Patrick Lim Soo , Sukhjeet Singh , Tsun P. Au Yeung , Charles-Andre Lemelin , Linda M. Custer
IPC分类号： A61K31/555 , A61K9/00 , A61K47/02 , A61K47/26 , A61P35/00 , A61K9/08 , A61K31/4015
摘要： The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein.
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公开(公告)号：US09937187B2
公开(公告)日：2018-04-10
申请号：US15179701
申请日：2016-06-10
发明人： Mark T. Bilodeau , Benoît Moreau , Adam H. Brockman , Kristan Meetze , Kerry Whalen , Richard Wooster , Rossitza G. Alargova
IPC分类号： C07F15/00 , A61K31/555 , A61K33/24 , A61K31/282
CPC分类号： A61K31/555 , A61K31/282 , A61K33/24 , C07F15/00
摘要： The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein, engineered protein, antibody, antibody fragment, peptide, agonist, antagonist, aptamer or ligand which may be capable of recognizing a selected target cell population, and/or derivatives/analogs/mimics thereof.
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公开(公告)号：US20180008614A1
公开(公告)日：2018-01-11
申请号：US15711041
申请日：2017-09-21
发明人： Mark T. Bilodeau , Benoît Moreau , Adam H. Brockman , Kristan Meetze , Kerry Whalen , Richard Wooster , Rossitza G. Alargova
IPC分类号： A61K31/555 , A61K31/282 , A61K33/24 , C07F15/00
CPC分类号： A61K31/555 , A61K31/282 , A61K33/24 , C07F15/00
摘要： The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein, engineered protein, antibody, antibody fragment, peptide, agonist, antagonist, aptamer or ligand which may be capable of recognizing a selected target cell population, and/or derivatives/analogs/mimics thereof.
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公开(公告)号：US09403858B2
公开(公告)日：2016-08-02
申请号：US14944610
申请日：2015-11-18
IPC分类号： C07D207/16 , C07D209/44 , C07F15/00 , A61K31/282 , A61K33/24
CPC分类号： A61K31/555 , A61K31/282 , A61K33/24 , C07F15/00
摘要： The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein, engineered protein, antibody, antibody fragment, peptide, agonist, antagonist, aptamer or ligand which may be capable of recognizing a selected target cell population, and/or derivatives/analogs/mimics thereof.
摘要翻译： 本教导涉及用于治疗癌症的化合物和组合物。 在一些实施方案中，组合物包含具有至少一个反应基团的铂（IV）络合物，所述反应基团可与蛋白质，工程改造的蛋白质，抗体，抗体片段，肽，激动剂，拮抗剂，适体或配体的官能团反应， 识别所选择的靶细胞群体和/或其衍生物/类似物/模拟物。
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公开(公告)号：US20190350940A1
公开(公告)日：2019-11-21
申请号：US16413719
申请日：2019-05-16
发明人： Rossitza G. Alargova , Mark T. Bilodeau , Richard Wooster , Benoît Moreau , Kerry Whalen , J. Michael Ramstack , Danielle N. Rockwood , Patrick Lim Soo , Sukhjeet Singh , Tsun P. Au Yeung , Charles-Andre Lemelin , Linda M. Custer
IPC分类号： A61K31/555 , A61K31/4015 , A61K47/26 , A61P35/00 , A61K9/00 , A61K9/08 , A61K47/02
摘要： The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein.
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公开(公告)号：US10287308B2
公开(公告)日：2019-05-14
申请号：US15652563
申请日：2017-07-18
发明人： Mark T. Bilodeau , Benoît Moreau
IPC分类号： C07F15/00
摘要： The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one polar moiety as a ligand.
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