公开(公告)号：US20230265071A1

公开(公告)日：2023-08-24

申请号：US18052462

申请日：2022-11-03

Applicant: Plexium, Inc.

Inventor： Pengyu Yang ,  Simon Bailey

IPC: C07D401/14

CPC classification number: C07D401/14

Abstract: Disclosed are compounds and salts thereof that bind to and modulate cereblon activity. In some embodiments, the binding and modulation of cereblon results in the degradation of IKAROS family zinc finger proteins (e.g., IKZF2). The compounds are of formula I:

公开(公告)号：US11878968B2

公开(公告)日：2024-01-23

申请号：US18052462

申请日：2022-11-03

Applicant: Plexium, Inc.

Inventor： Pengyu Yang ,  Simon Bailey

IPC: C07D401/14 ,  A61P35/00

CPC classification number: C07D401/14

Abstract: Disclosed are compounds and salts thereof that bind to and modulate cereblon activity. In some embodiments, the binding and modulation of cereblon results in the degradation of IKAROS family zinc finger proteins (e.g., IKZF2). The compounds are of formula I:

公开(公告)号：US20240246935A1

公开(公告)日：2024-07-25

申请号：US18496709

申请日：2023-10-27

Applicant: Plexium, Inc.

Inventor： Pengyu Yang ,  Simon Bailey

IPC: C07D401/14

CPC classification number: C07D401/14

Abstract: Disclosed are compounds and salts thereof that bind to and modulate cereblon activity. In some embodiments, the binding and modulation of cereblon results in the degradation of IKAROS family zinc finger proteins (e.g., IKZF2). The compounds are of formula I: