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公开(公告)号：US20150216927A1
公开(公告)日：2015-08-06
申请号：US14419986
申请日：2013-08-07
申请人： POLYPHOR AG
CPC分类号： A61K38/12 , A61K31/65 , A61K38/10 , A61K47/6809 , A61L2300/406 , C07K7/08 , C07K7/50 , C07K7/64 , A61K2300/00
摘要： A novel combination comprising a β-hairpin peptidomimetic of the formula cyclo(-Thr-Trp-Ile-Dab-Orn-DDab-Dab-Trp-Dab-Dab-Ala-Ser-DPro-Pro) (I), and a compound of the glycylcycline class, especially tigecycline, that enable therapeutic control of specific bacterial infections in human or animals at doses of the individual compounds lower than either of the compounds administered alone. The combination can be used as a medicament to treat e.g. skin or soft tissue infections; eye, ear, blood stream, or intra-abdominal infections; infections related to respiratory diseases, to bone diseases, to cardiovascular diseases, to genitourinal diseases, or to gastrointestinal diseases.
摘要翻译： 包含式（-Thr-Trp-Ile-Dab-Orn-DDab-Dab-Trp-Dab-Dab-Ala-Ser-DPro-Pro）（I）的式（b）所示肽模拟物的新型组合，和 甘氨酰环霉素类，特别是替加环素的化合物，其能够以比单独施用的化合物低的个体化合物的剂量治疗控制人或动物中的特定细菌感染。 该组合可以用作药物，例如治疗。 皮肤或软组织感染; 眼睛，耳朵，血液或腹内感染; 与呼吸系统疾病相关的感染，骨病，心血管疾病，生殖器疾病或胃肠道疾病。
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公开(公告)号：US10370412B2
公开(公告)日：2019-08-06
申请号：US15816955
申请日：2017-11-17
申请人： Polyphor AG
摘要： Beta-hairpin peptidomimetics of the general formula (I), cyclo[P1—P2—P3—P4—P5—P6—P7—P8—P9—P10—P11—P12-T1-T2], and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have broad spectrum Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials.These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
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公开(公告)号：US09938322B2
公开(公告)日：2018-04-10
申请号：US14781247
申请日：2014-03-28
申请人： POLYPHOR AG
CPC分类号： C07K7/64 , A61K38/00 , C07K7/08 , Y02A50/473
摘要： Beta-hairpin peptidomimetics of the general formula (I), cyclo[P1-p2-p3-p4-p5-p6-p7-p8-p9-p10-p11-p12-T1-T2], and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
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公开(公告)号：US11629171B2
公开(公告)日：2023-04-18
申请号：US16762394
申请日：2018-11-12
申请人： POLYPHOR AG
发明人： Daniel Obrecht , Anatol Luther , Francesca Bernardini , Glenn E. Dale , Nicolas Desjonqueres , Emile Brabet , Grégory Upert
摘要： Beta-hairpin peptidomimetics of the general formula (I), and pharmaceutically acceptable salts thereof, with P, X, Q., and optionally L being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli and/or Pseudomonas aeruginosa and/or Enterobacter cloacae. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
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公开(公告)号：US10654897B2
公开(公告)日：2020-05-19
申请号：US15515417
申请日：2015-09-29
申请人： POLYPHOR AG
发明人： Daniel Obrecht , Anatol Luther , Francesca Bernardini , Peter Zbinden , Sophie Barthelemy , Alexander Lederer
摘要： Beta-hairpin peptidomimetics of the general formula (I), cyclo[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-T1-T2] and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have Gramnegative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
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公开(公告)号：US09775877B2
公开(公告)日：2017-10-03
申请号：US14419986
申请日：2013-08-07
申请人： POLYPHOR AG
CPC分类号： A61K38/12 , A61K31/65 , A61K38/10 , A61K47/6809 , A61L2300/406 , C07K7/08 , C07K7/50 , C07K7/64 , A61K2300/00
摘要： A novel combination comprising a β-hairpin peptidomimetic of the formula cyclo(-Thr-Trp-Ile-Dab-Orn-DDab-Dab-Trp-Dab-Dab-Ala-Ser-DPro-Pro) (I), and a compound of the glycylcycline class, especially tigecycline, that enable therapeutic control of specific bacterial infections in human or animals at doses of the individual compounds lower than either of the compounds administered alone. The combination can be used as a medicament to treat e.g. skin or soft tissue infections; eye, ear, blood stream, or intra-abdominal infections; infections related to respiratory diseases, to bone diseases, to cardiovascular diseases, to genitourinal diseases, or to gastrointestinal diseases.
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公开(公告)号：US09850284B2
公开(公告)日：2017-12-26
申请号：US14781229
申请日：2014-03-28
申请人： POLYPHOR AG
CPC分类号： C07K7/64 , A61K38/00 , Y02A50/473
摘要： Beta-hairpin peptidomimetics of the general formula (I), cyclo(P1-p2-p3-p4-p5-p6-p7p8p9-p10-p11-p12-T1-T2], and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have broad spectrum Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
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公开(公告)号：US09814754B2
公开(公告)日：2017-11-14
申请号：US14419992
申请日：2013-08-07
申请人： POLYPHOR AG
IPC分类号： A61K38/12 , C07K5/12 , C07K7/64 , A61K45/06 , A61K31/405 , A61K31/496 , A61K31/7036 , A61K31/7052 , A61K31/407 , A61K47/48 , A61K38/00
CPC分类号： A61K38/12 , A61K31/405 , A61K31/407 , A61K31/496 , A61K31/7036 , A61K31/7052 , A61K38/00 , A61K45/06 , A61K47/6809 , C07K5/12 , C07K7/64 , A61K2300/00
摘要： A novel combination comprising a β-hairpin peptidomimetic of the formula cyclo(-Thr-Trp-Ile-Dab-Orn-DDab-Dab-Trp-Dab-Dab-Ala-Ser-DPro-Pro) (I), and a further compound with antibiotic activity, that enable therapeutic control of specific bacterial infections in human or animals at doses of the individual compounds lower than either of the compounds administered alone. The combination can be used as a medicament to treat e.g. skin or soft tissue infections; eye, ear, blood stream, or intra-abdominal infections; infections related to respiratory diseases, to bone diseases, to cardiovascular diseases, to genitourinal diseases, or to gastrointestinal diseases.
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公开(公告)号：US10829520B2
公开(公告)日：2020-11-10
申请号：US15560200
申请日：2016-03-23
申请人： POLYPHOR AG
摘要： Beta-hairpin peptidomimetics of the general formula (I), and pharmaceutically acceptable salts thereof, with P, T, Q, and optionally L being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli and/or Pseudomonas aeruginosa. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials.These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
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公开(公告)号：US10370411B2
公开(公告)日：2019-08-06
申请号：US15791087
申请日：2017-10-23
申请人： POLYPHOR AG
摘要： Beta-hairpin peptidomimetics of the general formula (I), cyclo[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-T1-T2], and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials.These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
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