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公开(公告)号：US20080274053A1
公开(公告)日：2008-11-06
申请号：US12172915
申请日：2008-07-14
IPC分类号： A61K51/00
CPC分类号： A61K49/08 , A61K49/1806
摘要： Various pathophysiological states are determined by evaluating the rate of 17O-containing water production oxygen using proton MRI. The method can be used to identify viable but threatened myocardium, injured by viable muscle, penumbra tissue in a stroke patient, and the like.
摘要翻译： 通过使用质子MRI评价含有 O的水生产氧的速率来确定各种病理生理状态。 该方法可以用于鉴定由活肌肉，中风患者中的半暗带组织等引起的可能但受威胁的心肌。
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公开(公告)号：US07410634B2
公开(公告)日：2008-08-12
申请号：US11250372
申请日：2005-10-17
IPC分类号： A61B5/055
CPC分类号： A61K49/08 , A61K49/1806
摘要： Various pathophysiological states are determined by evaluating the rate of 17O-containing water production oxygen using proton MRI. The method can be used to identify viable but threatened myocardium, injured by viable muscle, penumbra tissue in a stroke patient, and the like.
摘要翻译： 通过使用质子MRI评价含有 O的水生产氧的速率来确定各种病理生理状态。 该方法可以用于鉴定由活肌肉，中风患者中的半暗带组织等引起的可能但受威胁的心肌。
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公开(公告)号：US20140234224A1
公开(公告)日：2014-08-21
申请号：US14346920
申请日：2012-09-22
IPC分类号： A61K49/18
CPC分类号： A61K49/1806 , A61K49/06 , A61K49/10
摘要： Provided are compositions containing an emulsion containing a perfluorinated compound, as well as methods for preparation of the compositions. Also provided are formulations containing a complex of oxygen-17 and the emulsion compositions. Additionally provided are methods for the preparation of the formulations as well as kits containing the formulations. Further provided are methods of use of the formulations in imaging of tissues using a magnetic resonance imaging system.
摘要翻译： 提供含有含有全氟化合物的乳液的组合物，以及制备组合物的方法。 还提供了含有氧-17和乳液组合物的络合物的制剂。 另外提供了制备制剂的方法以及含有制剂的试剂盒。 进一步提供的是使用磁共振成像系统在组织成像中使用制剂的方法。
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公开(公告)号：US4592754A
公开(公告)日：1986-06-03
申请号：US530727
申请日：1983-09-09
申请人： Pradeep M. Gupte , Ravi K. Sundaram
发明人： Pradeep M. Gupte , Ravi K. Sundaram
IPC分类号： A61F2/06
摘要： The combination comprises a prosthetic vessel graft having a limited wall opening and a catheter device having at least two interconnected tubular arms extending through the wall opening and through the interior of the graft and through opposite ends of the graft. The end of each arm includes an inflatable balloon collar for secure connection to the interior of a vessel to be repaired by inflation of the balloon collar.In the method, the ends of the catheter arms are inserted and secured through small incisions in a vessel on either side of a section to be replaced by the graft. The section is removed, the graft is attached, the catheter is removed through the graft wall opening, and the wall opening is then closed.
摘要翻译： 该组合包括具有有限壁开口的假体血管移植物和具有至少两个相互连接的管状臂的导管装置，所述至少两个相互连接的管状臂延伸穿过壁开口并穿过移植物的内部并且穿过移植物的相对端。 每个臂的端部包括可充气的气囊套环，用于通过气囊套管的膨胀来固定连接到容器的内部以进行修复。 在该方法中，导管臂的端部插入并固定在通过移植物替代的部分的任一侧上的容器中的小切口。 切除该部分，移植物被连接，通过移植物壁开口移除导管，然后关闭壁开口。
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5.发明授权Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system 失效在磁共振成像系统中将氧-17引入用于成像的组织中的方法
公开(公告)号：US4996041A
公开(公告)日：1991-02-26
申请号：US234339
申请日：1988-08-19
IPC分类号： A61K49/00 , A61K49/18 , G01R33/28 , G01R33/465
CPC分类号： G01R33/5601 , A61K49/1806 , G01R33/465 , Y10T436/24
摘要： A diagnostic imaging agent is provided for use in conjunction with a magnetic resonance imaging system for the imaging of spacial oxygen distribution in tissue. The imaging agent is comprised of a complex of oxygen-17, a biologically acceptable liquid carrier, such as a perfluorinated compound, and an emulsifying agent, and wherein the agent has an average particle size of less than about 0.6 microns, and an ionic composition essentially equal to that of blood. Useful information can be obtained, and in certain instances, therapy administered, by a non-envasive imaging technique relative to tissue perfusion by .sup.19 F-NMR (imaging of .sup.19 F) and oxygen utilization by .sup.1 H-NMR (imaging of H.sub.2.sup.17 O as a metabolite).
摘要翻译： 提供诊断成像剂与磁共振成像系统一起用于组织中空间氧分布的成像。 成像剂由氧-17的复合物，生物学上可接受的液体载体如全氟化合物和乳化剂组成，并且其中所述试剂的平均粒径小于约0.6微米，并且离子组成 基本上等于血液。 可以获得有用的信息，在某些情况下，通过非侵入性成像技术相对于通过19F-NMR（19F成像）的组织灌注和通过1 H-NMR（H217O作为代谢物的成像）的氧利用来施用治疗。
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