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公开(公告)号：US5576300A
公开(公告)日：1996-11-19
申请号：US308883
申请日：1994-09-16
CPC分类号： C07K14/4732 , A23L33/19 , A61K38/00 , Y10S514/867 , Y10S530/832
摘要： A method of preventing or treating infection by human rotavirus by administering an enteral nutritional product containing either bovine .kappa.-casein or human .kappa.-casein at a concentration greater than that found in human or bovine milk and sufficient to inhibit infection of mammalian cells by human rotavirus.
摘要翻译： 一种预防或治疗人轮状病毒感染的方法，其通过以大于人或牛奶中发现的浓度施用含有牛κ-酪蛋白或人κ-酪蛋白的肠内营养产品，并且足以抑制人轮状病毒感染哺乳动物细胞 。
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2.发明授权
公开(公告)号：US5538952A
公开(公告)日：1996-07-23
申请号：US249555
申请日：1994-05-26
CPC分类号： C07K14/4732 , A23L33/19 , A61K38/018 , Y10S530/832
摘要： The infection of mammalian cells by RSV may be inhibited by native human .beta.-casein, a recombinant form of human .beta.-casein, and hydrolysates of both. The human .beta.-casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant formula. The enteral nutritional product may be used, for example, in the prevention and treatment of respiratory tract infection in infants. The human .beta.-casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.
摘要翻译： RSV的哺乳动物细胞感染可被天然人β-酪蛋白，人β-酪蛋白的重组形式和两者的水解产物所抑制。 人β-酪蛋白或水解产物可以包含在液体肠内营养产品如婴儿配方奶粉中。 肠内营养产品可用于例如预防和治疗婴儿呼吸道感染。 人类β-酪蛋白或水解产物也可以作为喉部喷雾剂或使用滴剂或喷雾剂鼻部施用。
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3.发明申请METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE AND FATTY ACIDS FOR TREATING DISEASE-ASSOCIATED WASTING 有权使用β-羟基 - 甲基丁酸酯与脂肪酸处理疾病相关的废物的方法公开(公告)号：US20120189717A1
公开(公告)日：2012-07-26
申请号：US13348035
申请日：2012-01-11
IPC分类号： A61K31/202 , A61K31/205 , A61P21/00 , A61K31/355 , A61K31/375 , A61K33/04 , A61K31/201 , A61K31/702
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and subtantially lacking in free amino acids.
摘要翻译： 本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。 在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 可以将HMB加入含有富含大中性氨基酸的氨基氮源如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且游离氨基酸不足的食品中。
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4.发明申请COMPOSITIONS INCLUDING BETA-HYDROXY-BETA-METHYLBUTYRATE AND USES THEREOF 审中-公开包括β-羟基-β-甲基丁酸酯的组合物及其用途公开(公告)号：US20120189715A1
公开(公告)日：2012-07-26
申请号：US13347978
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/702 , A61K31/375 , A61K33/04 , A61K31/717 , A61P35/00 , A61P11/00 , A61P31/18 , A61P19/02 , A61P1/16 , A61P1/00 , A61P13/12 , A61K31/355 , A61P3/00
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译： 本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。 在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。
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公开(公告)号：US20120189714A1
公开(公告)日：2012-07-26
申请号：US13347956
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/205 , A61K31/355 , A61P3/00 , A61K33/04 , A61P29/00 , A61P35/00 , A61K31/702 , A61K31/375
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译： 本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。 在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。
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6.发明申请公开(公告)号：US20120177752A1
公开(公告)日：2012-07-12
申请号：US13347985
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译： 本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。 在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。
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7.发明授权Method of using beta-hydroxy-beta-methylbutyrate and fatty acids for treating disease-associated wasting 有权使用β-羟基-β-甲基丁酸酯和脂肪酸治疗疾病相关性消耗的方法公开(公告)号：US08778994B2
公开(公告)日：2014-07-15
申请号：US13348035
申请日：2012-01-11
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and subtantially lacking in free amino acids.
摘要翻译： 本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。 在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 可以将HMB加入含有富含大中性氨基酸的氨基氮源如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且游离氨基酸不足的食品中。
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8.发明授权Method of using β-hydroxy-β-methylbutyrate for the treatment of disease conditions 有权用于治疗疾病的方法 - 用于治疗疾病的方法 - 羟基 - 甲基丁酸酯公开(公告)号：US08778993B2
公开(公告)日：2014-07-15
申请号：US13347877
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译： 本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。 在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。
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9.发明申请METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR TREATING DISEASE-ASSOCIATED WASTING 有权使用β-羟基-β-甲基丁酸酯治疗疾病相关废物的方法公开(公告)号：US20120189716A1
公开(公告)日：2012-07-26
申请号：US13348024
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/205 , A61K31/355 , A61P3/00 , A61K33/04 , A61P29/00 , A61P35/00 , A61K31/702 , A61K31/375
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译： 本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。 在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。
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10.发明申请METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR REDUCING TUMOR GROWTH RATE 失效使用β-羟基-β-甲基丁酸酯降低肿瘤生长速率的方法公开(公告)号：US20130011498A1
公开(公告)日：2013-01-10
申请号：US13348026
申请日：2012-01-11
IPC分类号： A61K31/202 , A61P35/00 , A61K31/355 , A61K33/04 , A61K31/205 , A61K31/702
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and subtantially lacking in free amino acids.
摘要翻译： 本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。 在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 可以将HMB加入含有富含大中性氨基酸的氨基氮源如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且游离氨基酸不足的食品中。
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