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1.发明授权Water-Miscible esters of mono- and diglycerides having antimicrobial activity and their use in inhibiting infection 失效具有抗微生物活性的甘油单酯和甘油二酯的水混溶性酯及其在抑制感染中的用途
公开(公告)号：US6136855A
公开(公告)日：2000-10-24
申请号：US356769
申请日：1999-07-16
申请人： Melinda Guzman-Harty , Milo Duane Hilty , Steven N. Anderson , Joseph Schaller , Terry Bruce Mazer , Theresa Siu-Ling Wai Lee , Lisa Ann Reaves , Jin-Zhou Liu
发明人： Melinda Guzman-Harty , Milo Duane Hilty , Steven N. Anderson , Joseph Schaller , Terry Bruce Mazer , Theresa Siu-Ling Wai Lee , Lisa Ann Reaves , Jin-Zhou Liu
摘要： A process of treating infection by a pathogenic microorganism in a subject in need of such treatment comprising the step of administering to the subject an effective antimicrobial amount of diacetyltartaric acid esters of mono- and diglycerides is provided. Pharmaceutical compositions containing diacetyltartaric acid esters of mono- and diglycerides as an active antimicrobial agent are also provided.
摘要翻译： 提供了一种治疗需要这种治疗的受试者中的致病微生物的感染的方法，其包括向受试者施用有效抗微生物量的甘油单酯和甘油二酯的二乙酰基酒石酸酯的步骤。 还提供含有甘油二酯和甘油二酯的二乙酰基酒石酸酯作为活性抗微生物剂的药物组合物。
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2.发明授权Nutritional formulations containing water-miscible lipid derivatives as antibacterial agents 失效含有水混溶性脂质衍生物作为抗菌剂的营养制剂
公开(公告)号：US5958974A
公开(公告)日：1999-09-28
申请号：US690737
申请日：1996-07-31
申请人： Steven N. Anderson , Milo Duane Hilty , Terry Bruce Mazer , Joseph Schaller , Melinda Guzman-Harty , Theresa Sui-Ling Wai Lee , Lisa Ann Reaves , Jin-Zhou Liu
发明人： Steven N. Anderson , Milo Duane Hilty , Terry Bruce Mazer , Joseph Schaller , Melinda Guzman-Harty , Theresa Sui-Ling Wai Lee , Lisa Ann Reaves , Jin-Zhou Liu
IPC分类号： A23L1/30 , A61K31/225 , A61K31/23
CPC分类号： A61K31/225 , A23L33/115 , A61K31/23
摘要： A nutritional formulation containing bactericidal amounts of diacetyltartaric acid esters of mono- and diglycerides is provided. A process of inhibiting bacterial infections including the step of feeding the nutritional composition to a subject is also provided.
摘要翻译： 提供了含有杀菌量的甘油单酯和甘油二酯的二乙酰酒石酸酯的营养制剂。 还提供了抑制细菌感染的方法，包括将营养组合物喂给受试者的步骤。
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3.发明授权Water-miscible esters of mono- and diglycerides having antimicrobial activity and their use in inhibiting infection 失效具有抗微生物活性的甘油单酯和甘油二酯的水混溶性酯及其在抑制感染中的用途
公开(公告)号：US5981587A
公开(公告)日：1999-11-09
申请号：US690724
申请日：1996-07-31
申请人： Melinda Guzman-Harty , Milo Duane Hilty , Steven N. Anderson , Joseph Schaller , Terry Bruce Mazer , Theresa Siu-Ling Wai Lee , Lisa Ann Reaves , Jin-Zhou Liu
发明人： Melinda Guzman-Harty , Milo Duane Hilty , Steven N. Anderson , Joseph Schaller , Terry Bruce Mazer , Theresa Siu-Ling Wai Lee , Lisa Ann Reaves , Jin-Zhou Liu
摘要： A process of treating infection by a pathogenic microorganism in a subject in need of such treatment including the step of administering to the subject an effective antimicrobial amount of diacetyltartaric acid esters of mono- and diglycerides is provided. Pharmaceutical compositions containing diacetyltartaric acid esters of mono- and diglycerides as an active antimicrobial agent are also provided.
摘要翻译： 本发明提供了治疗需要这种治疗的受试者中的致病微生物的感染的方法，包括向受试者施用有效抗微生物量的甘油二酯和甘油二酯的二乙酰酒石酸酯的步骤。 还提供含有甘油二酯和甘油二酯的二乙酰基酒石酸酯作为活性抗微生物剂的药物组合物。
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4.发明授权Nutritional formulations containing water-miscible lipid derivatives as anti-bacterial agents 失效含有水混溶性脂质衍生物作为抗菌剂的营养制剂
公开(公告)号：US6066669A
公开(公告)日：2000-05-23
申请号：US306608
申请日：1999-04-16
申请人： Steven N. Anderson , Milo Duane Hilty , Terry Bruce Mazer , Joseph Schaller , Melinda Guzman-Harty , Theresa Siu-Ling Wai Lee , Lisa Ann Reaves , Jin-Zhou Liu
发明人： Steven N. Anderson , Milo Duane Hilty , Terry Bruce Mazer , Joseph Schaller , Melinda Guzman-Harty , Theresa Siu-Ling Wai Lee , Lisa Ann Reaves , Jin-Zhou Liu
IPC分类号： A23L1/30 , A61K31/225 , A61K31/23 , A61K31/22
CPC分类号： A61K31/225 , A23L33/115 , A61K31/23
摘要： A nutritional formulation containing bacterial amounts of diacetyltartaric acid esters of mono- and diglycerides is provided. A process of inhibiting bacterial infections including the step of feeding the nutritional composition to a subject is also provided.
摘要翻译： 提供含有细菌量的甘油单酯和甘油二酯的二乙酰基酒石酸酯的营养制剂。 还提供了抑制细菌感染的方法，包括将营养组合物喂给受试者的步骤。
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5.发明授权Nutritional formulations containing water-miscible lipid derivatives as antibacterial agents 失效含有水混溶性脂质衍生物作为抗菌剂的营养制剂公开(公告)号：US06228886B1
公开(公告)日：2001-05-08
申请号：US09577423
申请日：2000-05-22
申请人： Steven N. Anderson , Milo Duane Hilty , Terry Bruce Mazer , Joseph Schaller , Melinda Guzman-Harty , Theresa Siu-Ling Wai Lee , Lisa Ann Reaves , Jin-Zhou Liu
发明人： Steven N. Anderson , Milo Duane Hilty , Terry Bruce Mazer , Joseph Schaller , Melinda Guzman-Harty , Theresa Siu-Ling Wai Lee , Lisa Ann Reaves , Jin-Zhou Liu
IPC分类号： A67K31225
CPC分类号： A61K31/225 , A23L33/115 , A61K31/23
摘要： A nutritional formulation containing bactericidal amounts of diacetyltartaric acid esters of mono- and diglycerides is provided. A process of inhibiting bacterial infections including the step of feeding the nutritional composition to a subject is also provided.
摘要翻译： 提供了含有杀菌量的甘油单酯和甘油二酯的二乙酰酒石酸酯的营养制剂。 还提供了抑制细菌感染的方法，包括将营养组合物喂给受试者的步骤。
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6.发明授权
公开(公告)号：US5538952A
公开(公告)日：1996-07-23
申请号：US249555
申请日：1994-05-26
CPC分类号： C07K14/4732 , A23L33/19 , A61K38/018 , Y10S530/832
摘要： The infection of mammalian cells by RSV may be inhibited by native human .beta.-casein, a recombinant form of human .beta.-casein, and hydrolysates of both. The human .beta.-casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant formula. The enteral nutritional product may be used, for example, in the prevention and treatment of respiratory tract infection in infants. The human .beta.-casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.
摘要翻译： RSV的哺乳动物细胞感染可被天然人β-酪蛋白，人β-酪蛋白的重组形式和两者的水解产物所抑制。 人β-酪蛋白或水解产物可以包含在液体肠内营养产品如婴儿配方奶粉中。 肠内营养产品可用于例如预防和治疗婴儿呼吸道感染。 人类β-酪蛋白或水解产物也可以作为喉部喷雾剂或使用滴剂或喷雾剂鼻部施用。
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7.发明授权Product for inhibition of infection of mammalian cells by respiratory syncytial virus 失效用于抑制呼吸道合胞病毒感染哺乳动物细胞的产品
公开(公告)号：US5506209A
公开(公告)日：1996-04-09
申请号：US249554
申请日：1994-05-26
CPC分类号： C07K14/4732 , A23L33/19 , A61K38/018 , Y10S530/832
摘要： The infection of mammalian cells by RSV may be inhibited by native human .beta.-casein, a recombinant form of human .beta.-casein, and hydrolysates of both. The human .beta.-casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant formula. The enteral nutritional product may be used, for example, in the prevention and treatment of respiratory tract infection in infants. The human .beta.-casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.
摘要翻译： RSV的哺乳动物细胞感染可被天然人β-酪蛋白，人β-酪蛋白的重组形式和两者的水解产物所抑制。 人β-酪蛋白或水解产物可以包含在液体肠内营养产品如婴儿配方奶粉中。 肠内营养产品可用于例如预防和治疗婴儿呼吸道感染。 人类β-酪蛋白或水解产物也可以作为喉部喷雾剂或使用滴剂或喷雾剂鼻部施用。
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8.发明授权
公开(公告)号：US5912372A
公开(公告)日：1999-06-15
申请号：US902366
申请日：1997-07-29
申请人： Terry Bruce Mazer , Steven N. Anderson , Melinda Guzman-Harty , Milo Duane Hilty , Theresa Sui-Ling Wai lee , Joseph Schaller , Jin-Zhou Liu
发明人： Terry Bruce Mazer , Steven N. Anderson , Melinda Guzman-Harty , Milo Duane Hilty , Theresa Sui-Ling Wai lee , Joseph Schaller , Jin-Zhou Liu
CPC分类号： C07C69/70
摘要： The present invention provides water-miscible lipid derivatives effective to inhibit the infectious activity of pathogenic microorganisms. Preferred water-miscible lipid derivatives are diacetyltartaric acid esters of monoglycerides wherein 90 percent or more of the fatty acid content is accounted for by a single fatty acid. The fatty acid component preferably contains from 8 to 24 and, more preferably, from about 10 to about 20 carbon atoms. The fatty acid can be saturated, unsaturated or hydroxylated.
摘要翻译： 本发明提供了有效抑制致病微生物感染活性的水混溶性脂质衍生物。 优选的与水可混溶的脂质衍生物是单酸甘油酯的二乙酰酒石酸酯，其中90％或更多的脂肪酸含量由单一脂肪酸占据。 脂肪酸组分优选含有8至24个，更优选约10至约20个碳原子。 脂肪酸可以是饱和的，不饱和的或羟基化的。
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9.发明授权Water-miscible esters of mono--and diglycerides having antibacterial activity and their use in inhibiting infection 失效具有抗菌活性的单甘油二酯和甘油二酯的水混溶性酯及其在抑制感染中的用途
公开(公告)号：US5908862A
公开(公告)日：1999-06-01
申请号：US690742
申请日：1996-07-31
申请人： Theresa Siu-Ling Wai Lee , Joseph Schaller , Steven N. Anderson , Terry Bruce Mazer , Milo Duane Hilty , Melinda Guzman-Harty , Jonathan Allan Meulbroek , Patricia Joan Ewing , Jin-Zhou Liu
发明人： Theresa Siu-Ling Wai Lee , Joseph Schaller , Steven N. Anderson , Terry Bruce Mazer , Milo Duane Hilty , Melinda Guzman-Harty , Jonathan Allan Meulbroek , Patricia Joan Ewing , Jin-Zhou Liu
IPC分类号： A61K31/22 , A61K31/225 , A61K31/23 , A61K31/231 , A61K31/731
CPC分类号： A61K31/731 , A61K31/22 , A61K31/225 , A61K31/23 , A61K31/231
摘要： A process of treating a bacterial infection in a subject in need of such treatment including the step of administering to the subject an effective bactericidal amount of diacetyltartaric acid esters of mono- and diglycerides is provided. Pharmaceutical compositions containing diacetyltartaric acid esters of mono- and diglycerides as an active bactericidal agent are also provided.
摘要翻译： 提供了治疗需要这种治疗的受试者的细菌感染的方法，包括向受试者施用有效杀菌量的甘油单酯和甘油二酯的二乙酰基酒石酸酯的步骤。 还提供含有甘油二酯和甘油二酯的二乙酰基酒石酸酯作为活性杀菌剂的药物组合物。
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10.发明授权Nutritional formulations containing water-miscible lipid derivatives as anti-microbial agents 失效含有水溶性脂质衍生物作为抗微生物剂的营养制剂
公开(公告)号：US5866606A
公开(公告)日：1999-02-02
申请号：US887452
申请日：1997-07-02
申请人： Joseph Schaller , Steven N. Anderson , Terry Bruce Mazer , Milo Duane Hilty , Melinda Guzman-Harty , Theresa Siu-Ling Wai Lee , Tammy Marie Bowman , Jill M. Lamm , Jin-Zhou Liu
发明人： Joseph Schaller , Steven N. Anderson , Terry Bruce Mazer , Milo Duane Hilty , Melinda Guzman-Harty , Theresa Siu-Ling Wai Lee , Tammy Marie Bowman , Jill M. Lamm , Jin-Zhou Liu
IPC分类号： A23L1/30 , A61K31/22 , A61K31/23 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , A61K31/20
摘要： A nutritional formulation containing an amount of diacetyltartaric acid esters of mono- and diglycerides effective to inhibit the infectious activity of pathogenic microorganisms is provided. A process of inhibiting the infectious activity of pathogenic microorganisms including the step of feeding the nutritional composition to a subject is also provided.
摘要翻译： 提供含有一定量的有效抑制病原微生物的感染活性的单甘油酯和甘油二酯的二乙酰酒石酸酯的营养制剂。 还提供了抑制致病微生物的感染活性的方法，包括将营养组合物喂给受试者的步骤。
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