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    PROCESS FOR PREPARING PHARMACEUTICAL OPHTHALMIC COMPOSITIONS
    3.
    发明申请
    PROCESS FOR PREPARING PHARMACEUTICAL OPHTHALMIC COMPOSITIONS 有权
    制备药物组合物的方法

    公开(公告)号：US20120283252A1

    公开(公告)日：2012-11-08

    申请号：US13513335

    申请日：2010-12-02

    申请人： Pravin Meghrajji Bhutada ,  Ashish Ashokrao Deshmukh ,  Sajeev Chandran ,  Shirishkumar Kulkarni

    发明人： Pravin Meghrajji Bhutada ,  Ashish Ashokrao Deshmukh ,  Sajeev Chandran ,  Shirishkumar Kulkarni

    IPC分类号： A61K31/542 ,  A61P27/02

    CPC分类号： A61K9/0048 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38

    摘要： Pharmaceutical ophthalmic compositions comprising active ingredient(s) such as carbonic anhydrase inhibitor (CAI) or combinations and processes for making such compositions and the use of these compositions in patient populations including pediatric populations. A process for preparing an ophthalmic composition comprising a carbonic anhydrase inhibitor, which comprises a) preparing a slurry comprising a carbonic anhydrase inhibitor and a surfactant; b) preparing a polymer slurry comprising a polymer and water; c) preparing a solution comprising tonicity and preservative agents; d) mixing the polymer slurry of step b and the solution of step c, to form a vehicle concentrate and adjusting pH; e) adding the slurry of step a, to the vehicle concentrate of step d and mixing to homogenize; f) autoclaving the mixture of step e; g) sizing the mixture of step f, under aseptic condition.

    摘要翻译： 包含活性成分如碳酸酐酶抑制剂（CAI）或组合的药物眼用组合物和用于制备此类组合物的方法以及这些组合物在包括儿科人群的患者群体中的用途。 一种制备包含碳酸酐酶抑制剂的眼用组合物的方法，其包括：a）制备包含碳酸酐酶抑制剂和表面活性剂的浆液; b）制备包含聚合物和水的聚合物浆料; c）制备包含张力和防腐剂的溶液; d）将步骤b的聚合物浆料和步骤c的溶液混合，形成载体浓缩物并调节pH值; e）将步骤a的浆料加入到步骤d的车辆浓缩物中并混合均匀; f）高压灭菌步骤e的混合物; g）在无菌条件下调整步骤f的混合物的尺寸。

    Process for preparing pharmaceutical ophthalmic compositions
    8.
    发明授权
    Process for preparing pharmaceutical ophthalmic compositions 有权
    制备药物眼用组合物的方法

    公开(公告)号：US08614210B2

    公开(公告)日：2013-12-24

    申请号：US13513335

    申请日：2010-12-02

    申请人： Pravin Meghrajji Bhutada ,  Ashish Ashokrao Deshmukh ,  Sajeev Chandran ,  Shirishkumar Kulkarni

    发明人： Pravin Meghrajji Bhutada ,  Ashish Ashokrao Deshmukh ,  Sajeev Chandran ,  Shirishkumar Kulkarni

    IPC分类号： A61P27/02 ,  A61K31/542

    CPC分类号： A61K9/0048 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38

    摘要： Pharmaceutical ophthalmic compositions comprising active ingredient(s) such as carbonic anhydrase inhibitor (CAI) or combinations and processes for making such compositions and the use of these compositions in patient populations including pediatric populations. A process for preparing an ophthalmic composition comprising a carbonic anhydrase inhibitor, which comprises a) preparing a slurry comprising a carbonic anhydrase inhibitor and a surfactant; b) preparing a polymer slurry comprising a polymer and water; c) preparing a solution comprising tonicity and preservative agents; d) mixing the polymer slurry of step b and the solution of step c, to form a vehicle concentrate and adjusting pH; e) adding the slurry of step a, to the vehicle concentrate of step d and mixing to homogenize; f) autoclaving the mixture of step e; g) sizing the mixture of step f, under aseptic condition.

    摘要翻译： 包含活性成分如碳酸酐酶抑制剂（CAI）或组合的药物眼用组合物和用于制备此类组合物的方法以及这些组合物在包括儿科人群的患者群体中的用途。 一种制备包含碳酸酐酶抑制剂的眼用组合物的方法，其包括：a）制备包含碳酸酐酶抑制剂和表面活性剂的浆液; b）制备包含聚合物和水的聚合物浆料; c）制备包含张力和防腐剂的溶液; d）将步骤b的聚合物浆料和步骤c的溶液混合，形成载体浓缩物并调节pH值; e）将步骤a的浆料加入到步骤d的车辆浓缩物中并混合均匀; f）高压灭菌步骤e的混合物; g）在无菌条件下调整步骤f的混合物的尺寸。