公开(公告)号：US11780821B2

公开(公告)日：2023-10-10

申请号：US16221398

申请日：2018-12-14

申请人： Praxis Biotech LLC

发明人： Jennifer Alfaro ,  Sebastian Belmar ,  Sebastian Bernales ,  Brahmam Pujala ,  Dayanand Panpatil ,  Bhawana Bhatt

IPC分类号： C07D401/12 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00 ,  C07D207/34 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/048

CPC分类号： C07D401/12 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00 ,  C07D207/34 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/048

摘要： Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.

公开(公告)号：US20200206216A1

公开(公告)日：2020-07-02

申请号：US16724198

申请日：2019-12-21

申请人： Praxis Biotech LLC

发明人： Brahmam Pujala ,  Dayanand Panpatil ,  Sebastian Bernales ,  Sebastian Belmar ,  Gonzalo Andrés Ureta Díaz

IPC分类号： A61K31/4709 ,  A61K31/192 ,  A61P35/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14

摘要： Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.

公开(公告)号：US11504364B2

公开(公告)日：2022-11-22

申请号：US16724198

申请日：2019-12-21

申请人： Praxis Biotech LLC

发明人： Brahmam Pujala ,  Dayanand Panpatil ,  Sebastian Bernales ,  Sebastian Belmar ,  Gonzalo Andrés Ureta Díaz

IPC分类号： C07D405/14 ,  A61K31/4709 ,  A61K31/192 ,  C07D401/12 ,  C07D401/14 ,  A61P35/00

摘要： Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.