公开(公告)号：US11230542B2

公开(公告)日：2022-01-25

申请号：US16219805

申请日：2018-12-13

Applicant: Praxis Biotech LLC

Inventor： Sebastian Bernales ,  Luz Marina Delgado Oyarzo ,  Gonzalo Esteban Núñez Vasquez ,  Gonzalo Andrés Ureta Díaz ,  Brahmam Pujala ,  Dayanand Panpatil ,  Bhawana Bhatt ,  Sarvajit Chakravarty

IPC: A61K31/44 ,  C07D413/12 ,  C07D263/24 ,  C07D307/85 ,  C07D401/12 ,  C07D405/12 ,  C07D215/18 ,  C07D211/58 ,  C07D491/048 ,  C07D277/68 ,  C12N5/00 ,  C07D265/36 ,  A61P35/00 ,  A61P21/00 ,  A61P25/28

Abstract: The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.

公开(公告)号：US11780821B2

公开(公告)日：2023-10-10

申请号：US16221398

申请日：2018-12-14

Applicant: Praxis Biotech LLC

Inventor： Jennifer Alfaro ,  Sebastian Belmar ,  Sebastian Bernales ,  Brahmam Pujala ,  Dayanand Panpatil ,  Bhawana Bhatt

IPC: C07D401/12 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00 ,  C07D207/34 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/048

CPC classification number: C07D401/12 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00 ,  C07D207/34 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/048

Abstract: Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.

公开(公告)号：US11166942B2

公开(公告)日：2021-11-09

申请号：US16432445

申请日：2019-06-05

Applicant: PRAXIS BIOTECH LLC

Inventor： Luz Marina Delgado Oyarzo ,  Gonzalo Andrés Ureta Díaz ,  Brahmam Pujala ,  Dayanand Panpatil ,  Sebastian Bernales ,  Sarvajit Chakravarty

IPC: A61K31/428 ,  A61K31/4468 ,  A61K31/4525 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/497 ,  A61K31/538 ,  A61P21/00 ,  A61P25/28 ,  C07D221/00 ,  C07D241/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07K16/00 ,  C12N5/073

Abstract: The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.

公开(公告)号：US20200206216A1

公开(公告)日：2020-07-02

申请号：US16724198

申请日：2019-12-21

Applicant: Praxis Biotech LLC

Inventor： Brahmam Pujala ,  Dayanand Panpatil ,  Sebastian Bernales ,  Sebastian Belmar ,  Gonzalo Andrés Ureta Díaz

IPC: A61K31/4709 ,  A61K31/192 ,  A61P35/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14

Abstract: Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.

公开(公告)号：US11504364B2

公开(公告)日：2022-11-22

申请号：US16724198

申请日：2019-12-21

Applicant: Praxis Biotech LLC

Inventor： Brahmam Pujala ,  Dayanand Panpatil ,  Sebastian Bernales ,  Sebastian Belmar ,  Gonzalo Andrés Ureta Díaz

IPC: C07D405/14 ,  A61K31/4709 ,  A61K31/192 ,  C07D401/12 ,  C07D401/14 ,  A61P35/00

Abstract: Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.

公开(公告)号：US11318133B2

公开(公告)日：2022-05-03

申请号：US16899521

申请日：2020-06-11

Applicant: Praxis Biotech LLC

Inventor： Luz Marina Delgado Oyarzo ,  Gonzalo Andrés Ureta Díaz ,  Brahmam Pujala ,  Dayanand Panpatil ,  Sebastian Bernales

IPC: C07D401/12 ,  A61K31/496 ,  A61K31/4709 ,  A61K31/47 ,  C07K14/435 ,  A61K45/06 ,  A01N43/60 ,  A01N43/42 ,  C07D215/06

Abstract: The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.