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公开(公告)号：US20230279349A1
公开(公告)日：2023-09-07
申请号：US17820425
申请日：2022-08-17
IPC分类号： C12N5/0783 , C12N15/11 , C12N15/113
CPC分类号： C12N5/0636 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2310/531
摘要： The present invention encompasses genetically-modified immune cells (and populations thereof) expressing a microRNA-adapted shRNA (shRNAmiR) that reduces the expression of a target endogenous protein. Methods for reducing the expression of an endogenous protein in an immune cell are also provided wherein the method comprises introducing a shRNAmiR that targets the endogenous protein. Using shRNAmiRs for knocking down the expression of a target protein allows for stable knockdown of expression of endogenous proteins in immune cells.
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公开(公告)号：US11384335B2
公开(公告)日：2022-07-12
申请号：US17511022
申请日：2021-10-26
发明人： Aaron Martin , Jon E. Chatterton
IPC分类号： C12N15/85 , C12N5/0783 , C12N15/11 , C12N15/113
摘要： The present invention encompasses genetically-modified immune cells (and populations thereof) expressing a microRNA-adapted shRNA (shRNAmiR) that reduces the expression of a target endogenous protein. Methods for reducing the expression of an endogenous protein in an immune cell are also provided wherein the method comprises introducing a shRNAmiR that targets the endogenous protein. Using shRNAmiRs for knocking down the expression of a target protein allows for stable knockdown of expression of endogenous proteins in immune cells.
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公开(公告)号：US20210254002A1
公开(公告)日：2021-08-19
申请号：US17225788
申请日：2021-04-08
IPC分类号： C12N5/0783 , C12N15/11
摘要： The present invention encompasses genetically-modified immune cells (and populations thereof) expressing a microRNA-adapted shRNA (shRNAmiR) that reduces the expression of a target endogenous protein. Methods for reducing the expression of an endogenous protein in an immune cell are also provided wherein the method comprises introducing a shRNAmiR that targets the endogenous protein. Using shRNAmiRs for knocking down the expression of a target protein allows for stable knockdown of expression of endogenous proteins in immune cells.
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公开(公告)号：US10745665B2
公开(公告)日：2020-08-18
申请号：US16678600
申请日：2019-11-08
发明人： Joann Hux , Aaron Martin , Derek Jantz , Clayton Beard
IPC分类号： C12N5/0783 , C07K14/725 , C07K14/74 , C07K16/28 , C12N15/113
摘要： The present disclosure provides nucleic acid molecules encoding an engineered antigen receptor, such as a chimeric antigen receptor or exogenous T cell receptor, and an inhibitory nucleic acid molecule, such as an RNA interference molecule. The present disclosure further relates to nucleic acids, DNA constructs, vectors, pharmaceutical compositions, genetically-modified cells, and methods of treatment that utilize the nucleic acid molecules of the invention.
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公开(公告)号：US20220228115A1
公开(公告)日：2022-07-21
申请号：US17712864
申请日：2022-04-04
发明人： Joann Hux , Aaron Martin , Derek Jantz , Clayton Beard
IPC分类号： C12N5/0783 , C07K14/725 , C07K14/74 , C07K16/28 , C12N15/113
摘要： The present disclosure provides nucleic acid molecules encoding an engineered antigen receptor, such as a chimeric antigen receptor or exogenous T cell receptor, and an inhibitory nucleic acid molecule, such as an RNA interference molecule. The present disclosure further relates to nucleic acids, DNA constructs, vectors, pharmaceutical compositions, genetically-modified cells, and methods of treatment that utilize the nucleic acid molecules of the invention.
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公开(公告)号：US20220204929A1
公开(公告)日：2022-06-30
申请号：US17694210
申请日：2022-03-14
IPC分类号： C12N5/0783 , C12N15/11 , C12N15/113
摘要： The present invention encompasses genetically-modified immune cells (and populations thereof) expressing a microRNA-adapted shRNA (shRNAmiR) that reduces the expression of a target endogenous protein. Methods for reducing the expression of an endogenous protein in an immune cell are also provided wherein the method comprises introducing a shRNAmiR that targets the endogenous protein. Using shRNAmiRs for knocking down the expression of a target protein allows for stable knockdown of expression of endogenous proteins in immune cells.
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7.发明申请公开(公告)号：US20210032664A1
公开(公告)日：2021-02-04
申请号：US17074135
申请日：2020-10-19
发明人： Victor Bartsevich , Christina Pham , Aaron Martin , Derek Jantz , James Jefferson Smith , Michael G. Nicholson
摘要： Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human beta-2 microglobulin gene. The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified T cells having reduced cell-surface expression of beta-2 microglobulin.
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8.发明申请公开(公告)号：US20190017075A1
公开(公告)日：2019-01-17
申请号：US16065756
申请日：2016-12-22
发明人： Victor Bartsevich , Christina Pham , Aaron Martin , Derek Jantz , James Jefferson Smith , Michael G. Nicholson
摘要： Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human beta-2 microglobulin gene. The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified T cells having reduced cell-surface expression of beta-2 microglobulin.
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公开(公告)号：US20240084252A1
公开(公告)日：2024-03-14
申请号：US18504548
申请日：2023-11-08
IPC分类号： C12N5/0783 , C12N15/11 , C12N15/113
CPC分类号： C12N5/0636 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2310/531
摘要： The present invention encompasses genetically-modified immune cells (and populations thereof) expressing a microRNA-adapted shRNA (shRNAmiR) that reduces the expression of a target endogenous protein. Methods for reducing the expression of an endogenous protein in an immune cell are also provided wherein the method comprises introducing a shRNAmiR that targets the endogenous protein. Using shRNAmiRs for knocking down the expression of a target protein allows for stable knockdown of expression of endogenous proteins in immune cells.
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公开(公告)号：US20230190780A1
公开(公告)日：2023-06-22
申请号：US17925277
申请日：2021-05-14
发明人： Christopher Ryan Heery , Daniel H. Fowler , Alan F. List , Aaron Martin , Daniel T. MacLeod , Derek Jantz
IPC分类号： A61K31/7056 , A61K31/675 , C07K16/28 , C07K14/725 , A61K31/436 , A61P35/00
CPC分类号： A61K31/7056 , A61K31/675 , C07K16/2893 , C07K14/7051 , A61K31/436 , A61P35/00 , A61K2039/545
摘要： The present invention encompasses methods for reducing the number of target cells in a subject, such as cancer cells. The methods include administration of genetically-modified human immune cells expressing a chimeric antigen receptor or exogenous T cell receptor, which have specificity for an antigen on the target cells Administration of the genetically-modified immune cells can be preceded by the administration of a lymphodepletion region and/or an immunosuppression regimen, to improve efficacy of the therapy and persistence of the cells in vivo.
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