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公开(公告)号：US11866747B2
公开(公告)日：2024-01-09
申请号：US18161560
申请日：2023-01-30
CPC分类号： C12N9/22 , C12N15/86 , C12N2750/14143 , C12N2750/14145
摘要： Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.
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公开(公告)号：US20230295590A1
公开(公告)日：2023-09-21
申请号：US18161560
申请日：2023-01-30
CPC分类号： C12N9/22 , C12N15/86 , C12N2750/14143 , C12N2750/14145
摘要： Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.
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公开(公告)号：US20240084276A1
公开(公告)日：2024-03-14
申请号：US18516247
申请日：2023-11-21
CPC分类号： C12N9/22 , C12N15/86 , C12N2750/14143 , C12N2750/14145
摘要： Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.
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4.发明公开公开(公告)号：US20240018495A1
公开(公告)日：2024-01-18
申请号：US18360312
申请日：2023-07-27
发明人： Gary Owens , Janel Lape , James Jefferson Smith , John Morris , Caitlin Turner , Whitney Lewis , Derek Jantz
CPC分类号： C12N9/22 , C12N15/86 , C12N2750/14143
摘要： The present disclosure encompasses engineered meganucleases that bind and cleave recognition sequences within a dystrophin gene. The present disclosure also encompasses methods of using such engineered meganucleases to make genetically modified cells. Further, the disclosure encompasses pharmaceutical compositions comprising engineered meganuclease proteins, or polynucleotides encoding engineered meganucleases of the disclosure, and the use of such compositions for the modification of a dystrophin gene in a subject, or for treatment of Duchenne Muscular Dystrophy.
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公开(公告)号：US20240200046A1
公开(公告)日：2024-06-20
申请号：US18556593
申请日：2022-04-22
发明人： Carlos T. Moraes , James Jefferson Smith , Derek Jantz , Ginger H. Tomberlin , John Morris , Wendy Shoop
CPC分类号： C12N9/22 , A61K9/127 , A61K38/465 , A61K48/005 , C12N15/86 , C07K2319/07 , C12N2750/14143
摘要： Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in combination with mitochondrial transit peptides in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been modified or edited.
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公开(公告)号：US11993793B2
公开(公告)日：2024-05-28
申请号：US18360517
申请日：2023-07-27
发明人： Gary Owens , Janel Lape , James Jefferson Smith , John Morris , Caitlin Turner , Whitney Lewis , Derek Jantz
CPC分类号： C12N9/22 , C12N15/86 , C12N2750/14143
摘要： The present disclosure encompasses engineered meganucleases that bind and cleave recognition sequences within a dystrophin gene. The present disclosure also encompasses methods of using such engineered meganucleases to make genetically modified cells. Further, the disclosure encompasses pharmaceutical compositions comprising engineered meganuclease proteins, or polynucleotides encoding engineered meganucleases of the disclosure, and the use of such compositions for the modification of a dystrophin gene in a subject, or for treatment of Duchenne Muscular Dystrophy.
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7.发明申请公开(公告)号：US20230053176A1
公开(公告)日：2023-02-16
申请号：US17931896
申请日：2022-09-13
发明人： Gary Owens , Janel Lape , James Jefferson Smith , John Morris , Caitlin Turner , Whitney Lewis , Derek Jantz
摘要： The present disclosure encompasses engineered meganucleases that bind and cleave recognition sequences within a dystrophin gene. The present disclosure also encompasses methods of using such engineered meganucleases to make genetically modified cells. Further, the disclosure encompasses pharmaceutical compositions comprising engineered meganuclease proteins, or polynucleotides encoding engineered meganucleases of the disclosure, and the use of such compositions for the modification of a dystrophin gene in a subject, or for treatment of Duchenne Muscular Dystrophy.
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8.发明公开公开(公告)号：US20240002823A1
公开(公告)日：2024-01-04
申请号：US18360517
申请日：2023-07-27
发明人： Gary Owens , Janel Lape , James Jefferson Smith , John Morris , Caitlin Turner , Whitney Lewis , Derek Jantz
CPC分类号： C12N9/22 , C12N15/86 , C12N2750/14143
摘要： The present disclosure encompasses engineered meganucleases that bind and cleave recognition sequences within a dystrophin gene. The present disclosure also encompasses methods of using such engineered meganucleases to make genetically modified cells. Further, the disclosure encompasses pharmaceutical compositions comprising engineered meganuclease proteins, or polynucleotides encoding engineered meganucleases of the disclosure, and the use of such compositions for the modification of a dystrophin gene in a subject, or for treatment of Duchenne Muscular Dystrophy.
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公开(公告)号：US11753630B2
公开(公告)日：2023-09-12
申请号：US17931896
申请日：2022-09-13
发明人： Gary Owens , Janel Lape , James Jefferson Smith , John Morris , Caitlin Turner , Whitney Lewis , Derek Jantz
CPC分类号： C12N9/22 , C12N15/86 , C12N2750/14143
摘要： The present disclosure encompasses engineered meganucleases that bind and cleave recognition sequences within a dystrophin gene. The present disclosure also encompasses methods of using such engineered meganucleases to make genetically modified cells. Further, the disclosure encompasses pharmaceutical compositions comprising engineered meganuclease proteins, or polynucleotides encoding engineered meganucleases of the disclosure, and the use of such compositions for the modification of a dystrophin gene in a subject, or for treatment of Duchenne Muscular Dystrophy.
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公开(公告)号：US20240141311A1
公开(公告)日：2024-05-02
申请号：US18556814
申请日：2022-04-22
发明人： Ralph Dewey , Derek Jantz , James Jefferson Smith , Ginger H. Tomberlin , John Morris , Anna Matthiadis , Wendy Shoop
CPC分类号： C12N9/22 , C12N15/8209 , C12N15/8289 , C07K2319/07
摘要： Disclosed herein are recombinant meganucleases engineered to bind and cleave a recognition sequence in the mitochondrial DNA (mtDNA) of a eukaryotic cell, such as a plant cell. The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.
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