公开(公告)号：US20230243812A1

公开(公告)日：2023-08-03

申请号：US18096629

申请日：2023-01-13

Applicant: President and Fellows of Harvard College

Inventor： Gilyong Lee ,  Sung-Jin Park ,  Kevin Kit Parker ,  Andre G. Kleber

IPC: G01N33/50

CPC classification number: G01N33/5088 ,  G01N33/5061

Abstract: Engineered cardiac tissue structures and methods for forming the engineered cardiac tissue structures are provided herein. An example engineered cardiac tissue structure includes a support having a first side and a first engineered cardiac tissue layer disposed at the first side of the support. The first engineered cardiac tissue layer can include a geometrically insulated cardiac tissue node. Another example engineered cardiac tissue structure includes a support, a first engineered cardiac tissue layer, and a second engineered cardiac tissue layer. Excitation and contraction of the first engineered cardiac tissue layer bends the support and strains the second engineered cardiac tissue layer inducing excitation and contraction of the second engineered cardiac tissue layer. The excitation and contraction of the second engineered cardiac tissue layer bends the support and strains the first engineered cardiac tissue layer inducing excitation and contraction of the first engineered cardiac tissue layer thereby producing antagonistic cyclic contractions.