公开(公告)号：US10997871B2

公开(公告)日：2021-05-04

申请号：US15514011

申请日：2015-09-24

Applicant: President and Fellows of Harvard College

Inventor： Kevin Kit Parker ,  Sung-Jin Park ,  Patrick Healy Campbell ,  Johan Ulrik Lind

IPC: G09B23/28 ,  C12M3/00 ,  C12M1/34 ,  C12M1/00 ,  G01N3/32 ,  C12N5/077 ,  C12M1/12 ,  G01N33/50

Abstract: Exemplary embodiments provide systems, devices and methods for simultaneously measuring mechanical and electrophysiological tissue responses (e.g., contractile function, or the like).

公开(公告)号：US09669141B2

公开(公告)日：2017-06-06

申请号：US14415945

申请日：2013-07-19

Applicant: President and Fellows of Harvard College ,  California Institute of Technology

Inventor： Kevin Kit Parker ,  Josue A. Goss ,  Sung-Jin Park ,  Andrew K. Capulli ,  Holly M. Golecki ,  Janna C. Nawroth ,  John O. Dabiri

IPC: A61M1/10 ,  A61F2/24 ,  G01N33/50 ,  A61M1/12

CPC classification number: A61M1/1003 ,  A61F2/2415 ,  A61M1/1037 ,  A61M1/1053 ,  A61M1/1098 ,  A61M1/12 ,  A61M1/122 ,  A61M1/127 ,  G01N33/5061 ,  G01N2500/04 ,  G01N2500/10 ,  Y10T29/49405

Abstract: The present invention provides tissue-engineered pumps and valves, methods of fabricating such pumps and valves, and methods of use of such pumps and valves.

公开(公告)号：US20230243812A1

公开(公告)日：2023-08-03

申请号：US18096629

申请日：2023-01-13

Applicant: President and Fellows of Harvard College

Inventor： Gilyong Lee ,  Sung-Jin Park ,  Kevin Kit Parker ,  Andre G. Kleber

IPC: G01N33/50

CPC classification number: G01N33/5088 ,  G01N33/5061

Abstract: Engineered cardiac tissue structures and methods for forming the engineered cardiac tissue structures are provided herein. An example engineered cardiac tissue structure includes a support having a first side and a first engineered cardiac tissue layer disposed at the first side of the support. The first engineered cardiac tissue layer can include a geometrically insulated cardiac tissue node. Another example engineered cardiac tissue structure includes a support, a first engineered cardiac tissue layer, and a second engineered cardiac tissue layer. Excitation and contraction of the first engineered cardiac tissue layer bends the support and strains the second engineered cardiac tissue layer inducing excitation and contraction of the second engineered cardiac tissue layer. The excitation and contraction of the second engineered cardiac tissue layer bends the support and strains the first engineered cardiac tissue layer inducing excitation and contraction of the first engineered cardiac tissue layer thereby producing antagonistic cyclic contractions.

公开(公告)号：US20180357927A1

公开(公告)日：2018-12-13

申请号：US15514011

申请日：2015-09-24

Applicant: President and Fellows of Harvard College

Inventor： Kevin Kit Parker ,  Sung-Jin Park ,  Patrick Healy Campbell ,  Johan Ulrik Lind

IPC: G09B23/28 ,  C12M3/00 ,  C12M1/34 ,  C12M1/00 ,  G01N33/50 ,  G01N3/32

CPC classification number: G09B23/28 ,  C12M21/08 ,  C12M25/02 ,  C12M31/10 ,  C12M41/46 ,  C12N5/0657 ,  G01N3/32 ,  G01N33/5091 ,  G01N2203/0089

Abstract: Exemplary embodiments provide systems, devices and methods for simultaneously measuring mechanical and electrophysiological tissue responses (e.g., contractile function, or the like).

公开(公告)号：US20150182679A1

公开(公告)日：2015-07-02

申请号：US14415945

申请日：2013-07-19

Applicant: President and Fellows of Harvard College ,  California Institute of Technology

Inventor： Kevin Kit Parker ,  Josue A. Goss ,  Sung-Jin Park ,  Andrew Keith Capulli ,  Holly A. McIlwee ,  Janna C. Nawroth ,  John O. Dabiri

IPC: A61M1/10 ,  A61F2/24 ,  G01N33/50 ,  A61M1/12

CPC classification number: A61M1/1003 ,  A61F2/2415 ,  A61M1/1037 ,  A61M1/1053 ,  A61M1/1098 ,  A61M1/12 ,  A61M1/122 ,  A61M1/127 ,  G01N33/5061 ,  G01N2500/04 ,  G01N2500/10 ,  Y10T29/49405

Abstract: The present invention provides tissue-engineered pumps and valves, methods of fabricating such pumps and valves, and methods of use of such pumps and valves.

Abstract translation: 本发明提供组织工程泵和阀，制造这种泵和阀的方法，以及这种泵和阀的使用方法。