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    METHODOLOGY OF DENTAL CARIES DETECTION
    1.
    发明申请
    METHODOLOGY OF DENTAL CARIES DETECTION 有权
    牙科检测方法

    公开(公告)号：US20160367446A1

    公开(公告)日：2016-12-22

    申请号：US15062708

    申请日：2016-03-07

    申请人： President and Fellows of Harvard College

    发明人： Shigemi Nagai ,  Masazumi Nagai

    IPC分类号： A61K6/00

    CPC分类号： A61K6/002 ,  A61B5/0088 ,  A61B5/4547 ,  A61C9/0006 ,  A61C17/00 ,  A61C19/063 ,  A61C19/066 ,  A61K6/007 ,  A61K6/083 ,  A61K6/087 ,  A61K6/10 ,  A61K8/24 ,  A61K8/37 ,  A61K8/466 ,  A61K49/006 ,  A61K2800/43 ,  A61K2800/434 ,  A61K2800/45 ,  A61K2800/58 ,  A61K2800/88 ,  A61Q11/00

    摘要： Disclosed are methods for detecting demineralization of a surface of a tooth, comprising a) contacting the tooth of a subject with an orally acceptable, binding composition comprising a binding agent that binds to a demineralized surface of the tooth; b) removing unbound binding compound; c) contacting the tooth with an orally acceptable, detector composition comprising a probe compound that reacts with the binding agent to form a visually detectable reaction product; and d) detecting formation of the reaction product as an indication of the presence or extent of surface demineralization of the tooth. Systems, kits, and compositions for practicing the methods are also provided.

    摘要翻译： 公开了用于检测牙齿表面脱矿质的方法，其包括：a）使受试者的牙齿与口服可接受的结合组合物接触，所述组合物包含与牙齿的去矿质化表面结合的粘合剂; b）除去未结合的化合物; c）使所述牙齿与口腔可接受的检测器组合物接触，所述组合物包含与所述结合剂反应以形成视觉上可检测的反应产物的探针化合物; 和d）检测反应产物的形成，作为牙齿表面脱矿质的存在或程度的指示。 还提供了用于实施该方法的系统，试剂盒和组合物。

    Compositions, methods and kits for remineralization and inhibition of dental caries in teeth
    3.
    发明申请
    Compositions, methods and kits for remineralization and inhibition of dental caries in teeth 审中-公开
    用于再矿化和抑制牙齿龋齿的组合物，方法和试剂盒

    公开(公告)号：US20140093457A1

    公开(公告)日：2014-04-03

    申请号：US13832445

    申请日：2013-03-15

    申请人： President and Fellows of Harvard College

    发明人： Shigemi Nagai

    IPC分类号： A61K6/00 ,  A61K33/42

    CPC分类号： A61K6/0058 ,  A61K31/6615 ,  A61K31/663 ,  A61K33/42 ,  A61K45/06 ,  A61K2300/00

    摘要： Methods, compositions and kits are provided for enhancing remineralization of a tooth or bone containing hydroxyapatite and inhibiting caries progression or loss of hydroxyapatite using a bisphosphonate or pyrophosphonate. The tooth or tooth surface contains a trauma or defect, for example the tooth contains a caries that is identified using a detectable probe. The bisphosphonate or pyrophosphonate is contacted to the tooth and/or oral cavity and binds to the hydroxyapatite material in the tooth or bone and prevents loss of hydroxyapatite material or strengthens the hydroxyapatite. The amount and extent of enhanced remineralization or of inhibition of caries progression and loss of hydroxyapatite are determined by techniques including photography, light microscopy and fluorescence microscopy.

    摘要翻译： 提供了方法，组合物和试剂盒，用于增强含有羟基磷灰石的牙齿或骨骼的再矿化，并使用双膦酸盐或焦磷酸盐抑制龋齿进展或羟基磷灰石的损失。 牙齿表面含有创伤或缺陷，例如牙齿含有使用可检测探针鉴定的龋齿。 双膦酸盐或焦磷酸盐与牙齿和/或口腔接触并结合到牙齿或骨骼中的羟基磷灰石材料，并防止羟基磷灰石材料的损失或增强羟基磷灰石。 通过包括摄影，光学显微镜和荧光显微镜在内的技术测定增强的再矿化或抑制龋齿进展和羟基磷灰石损失的量和程度。