公开(公告)号：US07683618B2

公开(公告)日：2010-03-23

申请号：US12048107

申请日：2008-03-13

申请人： Priti Balchandani ,  Daniel Spielman ,  John Pauly

发明人： Priti Balchandani ,  Daniel Spielman ,  John Pauly

IPC分类号： G01V3/00

CPC分类号： G01R33/4833

摘要： A manifestation of the invention provides a method for slice selective excitation for magnetic resonance imaging (MRI). A B0 field is applied. A STABLE pulse comprising of a BIR-4 envelope sampled by a plurality of subpulses with a duration is applied, where amplitude and frequency modulation functions of the BIR-4 envelope are slowly varying with respect to the duration of the subpulses. A portion of k-space is read out to obtain k-space data. The STABLE pulse and readout are repeated until sufficient k-space has been acquired. A Fourier Transform of the k-space data is taken.

摘要翻译： 本发明的一个表现提供了一种用于磁共振成像（MRI）的切片选择性激发的方法。 应用B0字段。 施加包括由具有持续时间的多个子脉冲采样的BIR-4包络的稳定脉冲，其中BIR-4包络的幅度和频率调制函数相对于子脉冲的持续时间缓慢变化。 读取k空间的一部分以获得k空间数据。 重复STABLE脉冲和读数，直到获得足够的k空间。 采用k空间数据的傅立叶变换。

公开(公告)号：US20090230958A1

公开(公告)日：2009-09-17

申请号：US12048107

申请日：2008-03-13

申请人： Priti Balchandani ,  Daniel Spielman ,  John Pauly

发明人： Priti Balchandani ,  Daniel Spielman ,  John Pauly

IPC分类号： G01R33/483

CPC分类号： G01R33/4833

摘要： A manifestation of the invention provides a method for slice selective excitation for magnetic resonance imaging (MRI). A B0 field is applied. A STABLE pulse comprising of a BIR-4 envelope sampled by a plurality of subpulses with a duration is applied, where amplitude and frequency modulation functions of the BIR-4 envelope are slowly varying with respect to the duration of the subpulses. A portion of k-space is read out to obtain k-space data. The STABLE pulse and readout are repeated until sufficient k-space has been acquired. A Fourier Transform of the k-space data is taken.

摘要翻译： 本发明的一个表现提供了一种用于磁共振成像（MRI）的切片选择性激发的方法。 应用B0字段。 施加包括由具有持续时间的多个子脉冲采样的BIR-4包络的稳定脉冲，其中BIR-4包络的幅度和频率调制函数相对于子脉冲的持续时间缓慢变化。 读取k空间的一部分以获得k空间数据。 重复STABLE脉冲和读数，直到获得足够的k空间。 采用k空间数据的傅立叶变换。

公开(公告)号：US20090137897A1

公开(公告)日：2009-05-28

申请号：US11944739

申请日：2007-11-26

申请人： Priti Balchandani ,  Daniel Spielman ,  John Pauly

发明人： Priti Balchandani ,  Daniel Spielman ,  John Pauly

IPC分类号： A61B5/05 ,  G01V3/00

CPC分类号： G01R33/485 ,  A61B5/05 ,  Y10T436/24

摘要： A method for performing spectroscopy using an interleaved readout for at least two species. A B0 field is applied. A first spatial-spectral (SPSP) position resolved spectroscopy sequence (PRESS) excitation with a sufficiently narrow band to excite a first species without exciting a second species is applied. A first readout that measures the first species is performed. A second SPSP PRESS excitation with a sufficiently narrow band to excite the second species without exciting the first species is applied. A second readout that measures the second species is performed.

摘要翻译： 一种使用至少两种物种的交错读出来进行光谱的方法。 应用B0字段。 应用具有足够窄带的第一空间光谱（SPSP）位置分辨光谱序列（PRESS）激发以激发第一种而不激发第二种。 执行测量第一个物种的第一个读数。 施加具有足够窄带以激发第二种而不激发第一种的第二SPSP PRESS激发。 执行测量第二物种的第二读数。

公开(公告)号：US07966053B2

公开(公告)日：2011-06-21

申请号：US11944739

申请日：2007-11-26

申请人： Priti Balchandani ,  Daniel Spielman ,  John Pauly

发明人： Priti Balchandani ,  Daniel Spielman ,  John Pauly

IPC分类号： A61B5/05 ,  G01N24/00 ,  G01V3/00

CPC分类号： G01R33/485 ,  A61B5/05 ,  Y10T436/24

摘要： A method for performing spectroscopy using an interleaved readout for at least two species. A B0 field is applied. A first spatial-spectral (SPSP) position resolved spectroscopy sequence (PRESS) excitation with a sufficiently narrow band to excite a first species without exciting a second species is applied. A first readout that measures the first species is performed. A second SPSP PRESS excitation with a sufficiently narrow band to excite the second species without exciting the first species is applied. A second readout that measures the second species is performed.

摘要翻译： 一种使用至少两种物种的交错读出来进行光谱的方法。 应用B0字段。 应用具有足够窄带的第一空间光谱（SPSP）位置分辨光谱序列（PRESS）激发以激发第一种而不激发第二种。 执行测量第一个物种的第一个读数。 施加具有足够窄带以激发第二种而不激发第一种的第二SPSP PRESS激发。 执行测量第二物种的第二读数。

公开(公告)号：US07821263B2

公开(公告)日：2010-10-26

申请号：US12136319

申请日：2008-06-10

申请人： Priti Balchandani ,  Daniel Spielman ,  John M. Pauly

发明人： Priti Balchandani ,  Daniel Spielman ,  John M. Pauly

IPC分类号： G01V3/00

CPC分类号： G01R33/5601 ,  G01R33/4833 ,  G01R33/4835

摘要： A method for frequency selective and slice selective magnetic resonance imaging (MRI) is provided. A B0 field is applied. A self-refocused spatial-spectral (SPSP) RF pulse is applied. A readout of a portion of k-space for the excited slice is performed. A second self-refocused SPSP excitation RF pulse is applied, wherein the second self-refocused SPSP excitation has an 180° echo phase difference from the self-refocused SPSP excitation. A second readout of a portion of k-space for the excited slice was performed. A difference between the readout and the second readout was found. The previous steps were repeated until k-space has been filled for the excited slice. The previous steps were repeated for a plurality of slices.

摘要翻译： 提供了频率选择和切片选择性磁共振成像（MRI）的方法。 应用B0字段。 应用自重聚焦空间光谱（SPSP）RF脉冲。 执行激励切片的k空间的一部分的读出。 应用第二个自重新聚焦的SPSP激励RF脉冲，其中第二自重聚焦SPSP激发与自重新聚焦的SPSP激发具有180°的回波相位差。 进行激发切片的k空间的一部分的第二次读出。 发现读出和第二读数之间的差异。 重复前面的步骤，直到激活切片填充k空间为止。 对于多个切片重复前面的步骤。

公开(公告)号：US20090315558A1

公开(公告)日：2009-12-24

申请号：US12136319

申请日：2008-06-10

申请人： Priti Balchandani ,  Daniel Spielman ,  John M. Pauly

发明人： Priti Balchandani ,  Daniel Spielman ,  John M. Pauly

IPC分类号： G01R33/48

CPC分类号： G01R33/5601 ,  G01R33/4833 ,  G01R33/4835

摘要： A method for frequency selective and slice selective magnetic resonance imaging (MRI) is provided. A B0 field is applied. A self-refocused spatial-spectral (SPSP) RF pulse is applied. A readout of a portion of k-space for the excited slice is performed. A second self-refocused SPSP excitation RF pulse is applied, wherein the second self-refocused SPSP excitation has an 180° echo phase difference from the self-refocused SPSP excitation. A second readout of a portion of k-space for the excited slice was performed. A difference between the readout and the second readout was found. The previous steps were repeated until k-space has been filled for the excited slice. The previous steps were repeated for a plurality of slices.

摘要翻译： 提供了频率选择和切片选择性磁共振成像（MRI）的方法。 应用B0字段。 应用自重聚焦空间光谱（SPSP）RF脉冲。 执行激励切片的k空间的一部分的读出。 应用第二个自重新聚焦的SPSP激励RF脉冲，其中第二自重聚焦SPSP激发与自重新聚焦的SPSP激发具有180°的回波相位差。 进行激发切片的k空间的一部分的第二次读出。 发现读出和第二读数之间的差异。 重复前面的步骤，直到激活切片填充k空间为止。 对于多个切片重复前面的步骤。

公开(公告)号：US20080057587A1

公开(公告)日：2008-03-06

申请号：US11469801

申请日：2006-09-01

申请人： Dirk Mayer ,  Yakir Levin ,  Daniel Spielman ,  Ralph Eugene Hurd

发明人： Dirk Mayer ,  Yakir Levin ,  Daniel Spielman ,  Ralph Eugene Hurd

IPC分类号： G01N33/00

CPC分类号： G01R33/485 ,  G01R33/5601 ,  Y10T436/24

摘要： A method of imaging the individual components of systems with sparse spectra using magnetic resonance imaging including the steps of a) exciting nuclei of labeled components using a MRI pulse sequence, b) selecting a proper spectral window to avoid/minimize signal overlap of aliased frequency components. In step a) preferably a spiral chemical shift imaging (spCSI) sequence is employed. In a preferred embodiment, hyperpolarized nuclei of 13C are used for labeling in a pyruvate substrate with metabolites of lacatate, alanine, and bicarbonate.

摘要翻译： 使用磁共振成像对具有稀疏光谱的系统的各个部件成像的方法，包括以下步骤：a）使用MRI脉冲序列激励标记分量的核; b）选择适当的光谱窗口以避免/最小化混叠频率分量的信号重叠 。 在步骤a）中优选使用螺旋化学位移成像（spCSI）序列。 在优选的实施方案中，13 C的超极化核用于在丙酮酸底物中用lacatate，丙氨酸和碳酸氢盐的代谢物进行标记。

公开(公告)号：US07709266B2

公开(公告)日：2010-05-04

申请号：US11469801

申请日：2006-09-01

申请人： Dirk Mayer ,  Yakir Levin ,  Daniel Spielman ,  Ralph Eugene Hurd

发明人： Dirk Mayer ,  Yakir Levin ,  Daniel Spielman ,  Ralph Eugene Hurd

IPC分类号： G01N24/00

CPC分类号： G01R33/485 ,  G01R33/5601 ,  Y10T436/24

摘要： A method of imaging the individual components of systems with sparse spectra using magnetic resonance imaging including the steps of a) exciting nuclei of labeled components using a MRI pulse sequence, b) selecting a proper spectral window to avoid/minimize signal overlap of aliased frequency components. In step a) preferably a spiral chemical shift imaging (spCSI) sequence is employed. In a preferred embodiment, hyperpolarized nuclei of 13C are used for labeling in a pyruvate substrate with metabolites of lacatate, alanine, and bicarbonate.

摘要翻译： 使用磁共振成像对具有稀疏光谱的系统的各个部件成像的方法，包括以下步骤：a）使用MRI脉冲序列激励标记分量的核; b）选择适当的光谱窗口以避免/最小化混叠频率分量的信号重叠 。 在步骤a）中优选使用螺旋化学位移成像（spCSI）序列。 在优选的实施方案中，13C的超极化核用于在丙酮酸底物中用lacatate，丙氨酸和碳酸氢盐的代谢物进行标记。