公开(公告)号：US20210393750A1

公开(公告)日：2021-12-23

申请号：US17287952

申请日：2019-10-24

申请人： ProThera Biologics, Inc.

发明人： Yow-Pin Lim ,  Denice Spero ,  Andre Richard Santoso

IPC分类号： A61K38/57 ,  A61K45/06 ,  A61K9/00 ,  A61P31/12 ,  A61P11/00 ,  A61P1/00 ,  A61P37/06 ,  G01N33/68 ,  C07K14/81 ,  A23L33/17 ,  A23L33/19 ,  A23L2/66 ,  A23C9/152 ,  A23L33/00

摘要： Featured are a foodstuff containing an inter-alpha inhibitor protein (lαlp) (e.g., lαl, Pαl, a heavy chain (e.g., H1, H2, H3, H4, and/or H5), a light chain (e.g., bikunin), or a combination thereof), methods of preparing a food-stuff containing an lαlp, and methods of treating and/or reducing the likelihood of developing a disease or condition (e.g., a disease or condition characterized by inflammation and/or low levels of an lαlp) in a subject in need thereof by administering a composition or a foodstuff containing an lαlp. Also featured are methods of purifying an lλlp (e.g., lαl, Pαl, a heavy chain (e.g., H1, H2, H3, H4, and/or H5), a light chain (e.g., bikunin), or a combination thereof) from milk.