公开(公告)号：US20180291084A1

公开(公告)日：2018-10-11

申请号：US16006968

申请日：2018-06-13

Applicant: Protalix Ltd.

Inventor： Yoseph SHAALTIEL ,  Uri HANANIA ,  Tali KIZHNER ,  Tami ARIEL ,  Svetlana GINGIS-VELITSKI ,  Myriam GOLEMBO

IPC: C07K14/715 ,  C12N15/82 ,  A61K38/17

Abstract: A plant produced chimeric polypeptide is provided. The plant produced chimeric polypeptide comprising: (i) a first domain which comprises a TNF Alpha binding domain of a TNF receptor, and (ii) a second domain which comprises an Fc domain of an immunoglobulin, wherein the first domain and the second domain are N-terminally to C-terminally respectively sequentially translationally fused and wherein the chimeric polypeptide specifically binds TNF Alpha.