公开(公告)号：US20180291084A1

公开(公告)日：2018-10-11

申请号：US16006968

申请日：2018-06-13

Applicant: Protalix Ltd.

Inventor： Yoseph SHAALTIEL ,  Uri HANANIA ,  Tali KIZHNER ,  Tami ARIEL ,  Svetlana GINGIS-VELITSKI ,  Myriam GOLEMBO

IPC: C07K14/715 ,  C12N15/82 ,  A61K38/17

Abstract: A plant produced chimeric polypeptide is provided. The plant produced chimeric polypeptide comprising: (i) a first domain which comprises a TNF Alpha binding domain of a TNF receptor, and (ii) a second domain which comprises an Fc domain of an immunoglobulin, wherein the first domain and the second domain are N-terminally to C-terminally respectively sequentially translationally fused and wherein the chimeric polypeptide specifically binds TNF Alpha.

公开(公告)号：US20180327476A1

公开(公告)日：2018-11-15

申请号：US16045848

申请日：2018-07-26

Applicant: Protalix Ltd.

Inventor： Yoseph SHAALTIEL ,  Uri HANANIA ,  Tali KIZHNER ,  Tami ARIEL ,  Svetlana GINGIS-VELITSKI

IPC: C07K14/705 ,  C12N15/82 ,  A61K36/81 ,  A61K38/17 ,  C07K14/415 ,  C07K14/525 ,  C07K14/715 ,  C12N5/04 ,  C12N5/14 ,  C12N15/09 ,  C12N15/62 ,  C12N5/10

Abstract: A plant produced chimeric polypeptide is provided. The plant produced chimeric polypeptide comprising: (i) a first domain which comprises a TNF Alpha binding domain of a TNF receptor, and (ii) a second domain which comprises an Fc domain of an immunoglobulin, wherein the first domain and the second domain are N-terminally to C-terminally respectively sequentially translationally fused and wherein the chimeric polypeptide specifically binds TNF Alpha.

公开(公告)号：US20160017019A1

公开(公告)日：2016-01-21

申请号：US14773349

申请日：2014-03-06

Applicant: PROTALIX LTD. ,  HADASIT MEDICAL RESEARCH SERVICE AND DEVELOPMENT LTD.

Inventor： Yaron ILAN ,  Yoseph SHAALTIEL ,  Uri HANANIA ,  Tali KIZHNER ,  Tami ARIEL ,  Svetlana GINGIS-VELITSKI

IPC: C07K14/705 ,  A61K9/00 ,  A61K36/81 ,  C12N15/82 ,  C07K16/24

CPC classification number: C07K14/70578 ,  A61K9/0053 ,  A61K36/81 ,  A61K38/00 ,  C07K14/525 ,  C07K16/241 ,  C07K2317/14 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/74 ,  C12N15/8257 ,  C12N15/8258

Abstract: A method of treating a TNF Alpha associated medical condition selected from the group consisting of obesity, metabolic syndrome, diabetes and a liver disease or disorder is provided. The method comprising enterally administering to a subject in need thereof a therapeutically effective amount of plant cells expressing a TNF Alpha polypeptide inhibitor, thereby treating the TNF Alpha associated medical condition.

Abstract translation: 提供了一种治疗选自肥胖症，代谢综合征，糖尿病和肝病或病症的TNFα相关医学病症的方法。 该方法包括向有需要的受试者肠道施用治疗有效量的表达TNFα多肽抑制剂的植物细胞，从而治疗TNFα相关的医学病症。

公开(公告)号：US20160017021A1

公开(公告)日：2016-01-21

申请号：US14773348

申请日：2014-03-06

Applicant: PROTALIX LTD.

Inventor： Yoseph SHAALTIEL ,  Uri HANANIA ,  Tali KIZHNER ,  Tami ARIEL ,  Svetlana GINGIS-VELITSKI

IPC: C07K14/715 ,  A61K38/17 ,  C07K14/415

Abstract: A plant produced TNF alpha polypeptide inhibitor is provided. Also provided are methods of generating and using same.

Abstract translation: 提供了植物产生的TNFα多肽抑制剂。 还提供了产生和使用它们的方法。

公开(公告)号：US20160017020A1

公开(公告)日：2016-01-21

申请号：US14773360

申请日：2014-03-06

Applicant: PROTALIX LTD.

Inventor： Yoseph SHAALTIEL ,  Uri HANANIA ,  Tali KIZHNER ,  Tami ARIEL ,  Svetlana GINGIS-VELITSKI

IPC: C07K14/705 ,  C07K14/415 ,  A61K36/81 ,  C12N15/82

CPC classification number: C07K14/70578 ,  A61K36/81 ,  A61K38/1793 ,  C07K14/415 ,  C07K14/525 ,  C07K14/7151 ,  C07K2319/02 ,  C07K2319/04 ,  C07K2319/30 ,  C12N5/04 ,  C12N5/10 ,  C12N5/14 ,  C12N15/09 ,  C12N15/62 ,  C12N15/82 ,  C12N15/8257 ,  C12N15/8258 ,  Y02A50/406

Abstract: A plant produced chimeric polypeptide is provided. The plant produced chimeric polypeptide comprising: (i) a first domain which comprises a TNF Alpha binding domain of a TNF receptor, and (ii) a second domain which comprises an Fc domain of an immunoglobulin, wherein the first domain and the second domain are N-terminally to C-terminally respectively sequentially translationally fused and wherein the chimeric polypeptide specifically binds TNF Alpha.