公开(公告)号：US20240263150A1

公开(公告)日：2024-08-08

申请号：US18429649

申请日：2024-02-01

Applicant: Protalix Ltd.

Inventor： Ilya RUDERFER ,  Yakir NATAF ,  Gil ARVATZ ,  Uri HANANIA ,  Tamar ARIEL ,  Shelly ROZEN ,  Yael HAYON ,  Zohar KEREN ,  Orit COHEN-BARAK

IPC: C12N9/06 ,  A61K9/00 ,  A61K31/519

CPC classification number: C12N9/0048 ,  A61K9/0019 ,  A61K31/519

Abstract: A method of treating a disease or disorder associated with excessive uric acid levels is disclosed herein. The method comprises administering to the subject by i.v. infusion an amount of a recombinant homotetrameric uricase enzyme comprising four uricase polypeptides having the amino acid sequence as set forth in SEQ ID NO: 2, wherein the polypeptides are crosslinked by polyethylene glycol (PEG) bis-aldehyde having a molecular weight of 2-3.5 kDa.