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公开(公告)号：US20190352265A1
公开(公告)日：2019-11-21
申请号：US16511774
申请日：2019-07-15
Applicant: Purdue Research Foundation
Inventor： Mohamed Seleem , Mingji Dai , Dexter Cameron Davis , Haroon Taj Mohammad
IPC: C07D213/38 , C07C291/10 , A61K31/277
Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.
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公开(公告)号：US20190352264A1
公开(公告)日：2019-11-21
申请号：US16511053
申请日：2019-07-15
Applicant: Purdue Research Foundation
Inventor： Mohamed Seleem , Mingji Dai , Dexter Cameron Davis , Haroon Taj Mohammad
IPC: C07D213/38 , C07C291/10 , A61K31/277
Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.
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公开(公告)号：US10449174B2
公开(公告)日：2019-10-22
申请号：US15456950
申请日：2017-03-13
Applicant: Purdue Research Foundation
Inventor： Kwaku Kyei-Baffour , Mohamed Seleem , Mingji Dai , Haroon Taj Mohammad
IPC: A61K31/277 , A61K31/4402 , A61K31/4406 , A61K31/4409 , C07D213/38 , C07C291/10
Abstract: Invasive fungal infections present a formidable global public health challenge due to the limited number of approved antifungal agents and the emergence of resistance to the frontline treatment options, such as fluconazole. Three fungal pathogens of significant concern are Candida, Cryptococcus, and Aspergillus given their propensity to cause opportunistic infections in immunocompromised individuals. This disclosure provides a set of aryl isonitrile compounds that possess broad-spectrum antifungal activity primarily against species of Candida and Cryptococcus. The most potent derivatives are capable of inhibiting growth of these key pathogens at concentrations as low as 0.5 μM. Remarkably, the most active compounds exhibit an excellent safety profile and are non-toxic to mammalian cells even at concentrations up to 256 μM.
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公开(公告)号：US10364224B2
公开(公告)日：2019-07-30
申请号：US15090619
申请日：2016-04-04
Applicant: Purdue Research Foundation
Inventor： Mohamed Seleem , Mingji Dai , Dexter Cameron Davis , Haroon Taj Mohammad
IPC: A61K31/277 , C07C291/10 , C07D213/38 , A61K31/4402 , A61K31/4406 , A61K31/4409
Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.
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公开(公告)号：US11198674B2
公开(公告)日：2021-12-14
申请号：US16511774
申请日：2019-07-15
Applicant: Purdue Research Foundation
Inventor： Mohamed Seleem , Mingji Dai , Dexter Cameron Davis , Haroon Taj Mohammad
IPC: C07D213/38 , C07C291/10 , A61K31/277 , A61K31/4406 , A61K31/4409 , A61K31/4402
Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20170181997A1
公开(公告)日：2017-06-29
申请号：US15456950
申请日：2017-03-13
Applicant: Purdue Research Foundation
Inventor： Kwaku Kyei-Baffour , Mohamed Seleem , Mingji Dai , Haroon Taj Mohammad
IPC: A61K31/277 , A61K31/4406 , A61K31/4409 , A61K31/4402
CPC classification number: A61K31/277 , A61K31/4402 , A61K31/4406 , A61K31/4409 , C07C291/10 , C07C2601/14 , C07D213/38
Abstract: Invasive fungal infections present a formidable global public health challenge due to the limited number of approved antifungal agents and the emergence of resistance to the frontline treatment options, such as fluconazole. Three fungal pathogens of significant concern are Candida, Cryptococcus, and Aspergillus given their propensity to cause opportunistic infections in immunocompromised individuals. This disclosure provides a set of aryl isonitrile compounds that possess broad-spectrum antifungal activity primarily against species of Candida and Cryptococcus. The most potent derivatives are capable of inhibiting growth of these key pathogens at concentrations as low as 0.5 μM. Remarkably, the most active compounds exhibit an excellent safety profile and are non-toxic to mammalian cells even at concentrations up to 256 μM.
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7.发明申请公开(公告)号：US20160287550A1
公开(公告)日：2016-10-06
申请号：US15090619
申请日：2016-04-04
Applicant: Purdue Research Foundation
Inventor： Mohamed Seleem , Mingji Dai , Dexter Cameron Davis , Haroon Taj Mohammad
IPC: A61K31/277 , C07C291/10 , A61K31/4409 , C07D213/38 , A61K31/4402 , A61K31/4406 , A61K45/06 , C07C205/06
CPC classification number: C07D213/38 , A61K31/277 , A61K31/4402 , A61K31/4406 , A61K31/4409 , C07C291/10 , C07C2601/14
Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.
Abstract translation: 本发明提供具有抗菌性能的芳基异腈化合物。 更具体地，本发明的芳基异腈化合物是金黄色葡萄球菌耐药株的有效抑制剂。
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公开(公告)号：US11731964B2
公开(公告)日：2023-08-22
申请号：US17046957
申请日：2019-03-29
Applicant: Purdue Research Foundation
Inventor： Herman O. Sintim , Mohamed Seleem , Clement Opoku-Temeng , Haroon Taj Mohammad , George Naclerio
IPC: C07D417/14 , A61P31/04 , C07D409/14 , C07D413/12 , C07D413/14
CPC classification number: C07D417/14 , A61P31/04 , C07D409/14 , C07D413/12 , C07D413/14
Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Clostridioides difficile. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
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公开(公告)号：US11098014B2
公开(公告)日：2021-08-24
申请号：US16511053
申请日：2019-07-15
Applicant: Purdue Research Foundation
Inventor： Mohamed Seleem , Mingji Dai , Dexter Cameron Davis , Haroon Taj Mohammad
IPC: C07D213/38 , C07C291/10 , A61K31/277 , A61K31/4406 , A61K31/4409 , A61K31/4402
Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.
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公开(公告)号：US11091437B2
公开(公告)日：2021-08-17
申请号：US16443945
申请日：2019-06-18
Applicant: Purdue Research Foundation
Inventor： Mohamed Seleem , Mingji Dai , Dexter Cameron Davis , Haroon Taj Mohammad
IPC: C07D213/38 , C07C291/10 , A61K31/277 , A61K31/4406 , A61K31/4409 , A61K31/4402
Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.
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