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    Raman tag
    2.
    发明授权
    Raman tag 有权

    公开(公告)号：US10131687B2

    公开(公告)日：2018-11-20

    申请号：US15634567

    申请日：2017-06-27

    申请人： Purdue Research Foundation

    发明人： Mingji Dai

    IPC分类号： C07J9/00 ,  C07J17/00 ,  C07J41/00 ,  G01N33/52

    摘要： A method of forming a probe, wherein the method includes converting cholenic acid into a compound with a terminal alkyne group, wherein the converting the cholenic acid comprises using a sequence, wherein the sequence comprises synthesizing a THP-protection group, LiAlH4 reduction, Dess-Martin oxidation, and Seyferth-Gilbert-Bestmann homologation. The method additionally includes forming A-Chol by removing the THP-protection. Further, the method includes forming PhA-Chol from the compound with the terminal alkyne group via a palladiumcatalyzed Sonogashira reaction. Additionally, the method includes forming PhDY-Chol from the compound with the terminal alkyne group via a coppercatalyzed Cadiot-Chodkiewicz reaction.

    RAMAN TAG
    7.
    发明申请
    RAMAN TAG 审中-公开

    公开(公告)号：US20190085019A1

    公开(公告)日：2019-03-21

    申请号：US16197250

    申请日：2018-11-20

    申请人： Purdue Research Foundation

    发明人： Mingji Dai

    IPC分类号： C07J9/00 ,  G01N33/52 ,  C07J41/00 ,  C07J17/00

    摘要： A method of forming a probe, wherein the method includes converting cholenic acid into a compound with a terminal alkyne group, wherein the converting the cholenic acid comprises using a sequence, wherein the sequence comprises synthesizing a THP-protection group, LiAlH4 reduction, Dess-Martin oxidation, and Seyferth-Gilbert-Bestmann homologation.